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임신 2기의 임신중절에서 misoprostol과 sulprostone의 임상적 효용성 비교
김정규 ( Jeong Kyu Kim ),문종필 ( Jong Pil Moon ),김용범 ( Yong Beom Kim ),지일운 ( Ill Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( Hak Soon Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
목적 : 임신 2기의 유산에 있어서 misoprostol과 sulprostone의 임상적 효용성을 비교해 보고자 하였다. 연구 방법 : 임신 2기에 유산을 요하는 환자들을 misoprostol군과 sulprostone군으로 무작위로 배정한 후, 임신 20주를 기준으로 각각 다시 세분하였다. Misoprostol군에서 임신 20주 이하는 misoprostol 400 킽을 4시간마다 질내에 삽입하였고, 임신 20주 이후에는 200 킽을 6시간마다 삽입하였다 Objective : Our purpose was to compare the clinical efficacy of intravaginal misoprostol and that of intravenous sulprostone for termination of second-trimester pregnancy. Methods : The patients were assigned to misoprostol and sulprostone group, and the
이완성 자궁출혈환자에서 프로스타글란딘 E2 투여 후 발생한 고열, 관상동맥 연축 및 경련
박준철 ( Joon Cheol Park ),배진곤 ( Jin Gon Bae ),김종인 ( Jong In Kim ),이정호 ( Jeong Ho Rhee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.5
Postpartum hemorrhage is a serious condition related with maternal morbidity and mortality. Prior to surgical treatment, oxytocin and prostaglandin analogs administration are common. Pyrexia after prostaglandin E1 was well known, but PG E2 has been shown to have a few complication even though coronary arterial spasm was rarely reported. The 38-year old woman who delivered 3rd baby by Cesarean section was developed the atonic uterine bleeding. During the treatment with high dose sulprostone (PG E2), she complained the anterior chest pain, her body temperature was elevated to 41.2℃, and then convulsion with stuporous mentality was developed. EKG revealed inverted T wave in II. III, aVF lead, and CK-MB, troponin I was elevated. The laboratory test revealed elevated SGOT/SGPT, myoglobin, and metabolic acidosis. But CSF study, blood culture, direct/indirect Coomb`s test, brain CT, and echocardiography were all negative. After supportive care, she came to be alert after 10 hours, body temperature was returned to normal after 22 hours, and the laboratory tests were eventually returned to normal within 6 days. She was discharged from the hospital without any complication. We postulate that high dose PG E2 resulted in high fever, coronary artery spasm, and convulsion.