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김진영,배성미,홍경자,라현오,김양리,강문원 한국병원약사회 1999 병원약사회지 Vol.16 No.1
In order to find out whether ceftriaxone, a third generation cephalosporin antibiotics, is used appropriately, safely and effectively, DUE study was conducted by reviewing 70 charts of patients who were treated at Kangnam St. Mary's hospital from Oct. 1997 to Nov. 1997. The DUE criteria was modified from the criteria on ceftriaxone use established by American Society of Health-System Pharmacists. As a result, 33 cases (47.2%) were met with criteria for the justification of use. The analysing process indicators including CBC, SCr were taken before the initial dose and the vital sign monitoring were relatively well documented showing the accepted levels of above 80%. On the other hand, blood sampling for the culture and sensitivity test before the initial antibiotic dose WBC Count, SCr, LFT during the therapy were in low accepted levels. As an outcome analysis, the result of blood culture after discontinuing drug were documented with accepted level of 24.3%. As a conclusion, it is suggested that above finding should be communicated to the medical staff, and an active intervention, such as feedback control system by pharmacist, also be necessary for the rational medication use.
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김승희,배성미,홍경자,라현오,김양리,강문원 한국병원약사회 1998 병원약사회지 Vol.15 No.4
A restrospective Drug Use Evaluation(DUE) study was conducted by reviewing medical records of 38 patients, who were given vancomycin during their hospitalization period at Kangnam St. Mary's hospital, from 1 Oct 1997 to 31 November 1997. The criteria was midified from the criteria on vancomycin established by American society of Health-System Pharmacists(ASHP). As a result, 27 cases(71.1%) were met with the criteria for the justification of use. In 33 cases(86.8%), blood culture tests were performed within 48 hours before the initial doses. In 34 cases(89.5%), serum creatinine tests were conducted within 48 hours before the initial doses. In 22 cases(57.9%), fever peaks decreased at least 1 degree within 3 days after the initial dose and in 22 cases(57.9%), WBC values were in normal range after treatment. According to the study, inappropriate use of vancomycin was up to 28.9%. considering that vancomycin is categorized into one of restricted antibiotics, which can be used with an approval of infection specialist in the hospital, a more thorough control on use of vancomycin is required. Moreover, renal test should be carried out periodically before and during the use of vancomycin to prevent, if any, adverse reactions.
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