폐경기 여성에서 칼슘 제품간의 생체이용률 비교

배성미,양성희,최선,한옥연,권혁상,윤건호 한국병원약사회 2002 병원약사회지 Vol.19 No.4

Despite the potential utility of calcium supplements in menopausal women, there are few data concerning the absorbability of different calcium salts. This four phase cross over study was conducted to compare pharmacokinetic indices of calcium absorption after a single oral administration(600㎎ as an elemental calcium). We selected calcium lactate and calcium gluconate, calcium carbonate, ergocalciferol complement(A), calcium carbonate and cholecalciferol complement(B) as calcium salts and vitamin D complexes, and calcium carbonate (C), calcium citrate(D) as mono calcium salts. In 8 healthy postmenopausal women aged 45-61(mean:54.9years), venous blood samples were obtained for the measurement of serum calcium concentration before and at 1, 3, 5 hours after preload, at 3 hours A(0.613±0.557) and C(0.5±0.472) showed higher than D(-0.113±0.398), and at 5 hours A(0.650±0.607) and B(0.588±0.146) were higher than D(0.075±0.296) (p<0.05). Among the four supplements only A(2.17±1.99) had greater change in area under the curve (ΔAUC_(1~5hr)of C with D, and C with B, and A with B. Only C(1.57±1.42) had higher ΔAUC_(1~5hr) than D(-0.25±1.27, p=0.018). Comparing bioavailability of four commercial calcium supplements by ΔAUC_(1~5hr) calcium citrate(D) had relatively lower bioavailability and we couldn't convince that vitamin D complexes had higher bioavailability than mono calcium salts. Considering the similarity in bioavailability of each calcium supplements, it is favorable so select calcium supplements according to the patient compliance, simplicity of taking the medicine or medical cost.

아이덴터티(identity factor)로서의 공동브랜드화 전략 -화성시 농 특산물 공동브랜드 개발을 중심으로-

배성미 한국기초조형학회 2004 기초조형학연구 Vol.5 No.1

The purposes of this paper are twofold: to point out problems of brand designs of agricultural products & specialities in many local areas and to suggest alternative strategies for area-common brand designs.In developing desirable area-common brand designs of agricultural products & specialities in a local area, at least three factors should be considered: survey and analysis of consumers' behaviors; integration of characteristics of both the local area and its agricultural products & specialities; consistent application of an identity factor to area-common brand designs for positioning as powerful brand designs. 본 연구는 현재 우후죽순처럼 개발되고 난립하고 있는 농산물 공동브랜드의 문제점을 인식하고 농 특산물 공동 브랜드의 차별적 요소를 아이덴터티적 요소로서 전략화 하는 방안을 화성시를 대표하는 농 특산물 공동 브랜드 개발 사례를 통하여 제시하고자 한다. 그리하여 한 도시의 농 특산물 공동 브랜드가 개발됨에 있어서 고려되는 소비자 조사 및 분석과 농 특산물 특수성에 맞는 지역적 특징을 통합한 브랜드 개발 전략과 브랜드 아이덴터티 요소의 일관된 적용을 통한 전 매체 적 표현 방법을 제시하여 한 도시의 개발된 공동브랜드가 파워 브랜드로 포지셔닝 하기 위한 실제적 한 방안을 아이덴터티 팩터로서 제시함으로서 농 특산물 브랜드화의 올바른 방향 설정에 기여하고자 하였다.

반코마이신의 임상약동학 모니터링 서비스에 대한 임상적 및 경제적 손익의 평가

배성미,안혜림,홍경자,나현오,조혜경 한국임상약학회 2001 한국임상약학회지 Vol.11 No.1

This research is conducted to evaluate the clinical and economic benefits from therapeutic drug monitoring(TDM) service on vancomycin in a tertiary general hospital. Total 99 pairs of steady state peak and trough concentrations of vancomycin were obtained from 73 patients. To see the clinical benefits, the appropriateness of vancomycin dosing before TDM was evaluated. In 72 pairs of vancomycin blood concentrations obtained prior to TDM consultation, of the cases had reached within therapeutic range. Serum vancomycin levels in patients with $40{\leq}CLcr<60$ (ml/min) were higher and than the levels in patients with 40>CLcr and (ml/min). Dose reduction rate in patients with creatinine clearance $40{\leq}CLcr<60$ (ml/min) were also significantly higher than those of compared groups (, p=0.0138). Serum vancomycin concentrations were re-obtained from 21 patients who received modified dose through TDM service. Ninety percent (19/21cases) of them were within the target therapeutic range. For the evaluation of economic benefits from TDM consultation, estimated cost savings were calculated in those patients. The total drug saving were 586 vials in 21 patients. The calculated mean cost saving from the drugs was 314,570 won (range: per patient. The study revealed that TDM service for vancomycin is necessary because empirical dosing is not effective for obtaining therapeutic drug level, especially patients with mild renal insufficiencies. The cost saving from TDM is also beneficial for the patients.

한국 주식시장에서의 유동성위험의 평가

배성미,김종대,안형태,조문기 한국기업경영학회 2016 기업경영연구 Vol.23 No.4

This study investigates if liquidity risk can explain individual stock returns as a systematic risk in the Korean stock market. And, it examines whether market liquidity and its unexpected change increase at times of liquidity crisis such as the foreign currency crisis during 1997-1999 and the global financial crisis during 2007-2009 periods. It also tests if the liquidity risk itself, a sensitivity of individual stock return to unexpected change in market liquidity, increases at times of liquidity crisis. The final sample of 139,468 firm-months for periods of 1992∼2012 that satisfy the sample selection criteria. All sample firms are listed in the Korean stock market. The results indicate that the liquidity risk is evaluated by the investors as a systematic risk in addition to the market beta, firm size and book-to-market ratio that are known as systematic risks. That is, a significant positive correlation was found between unexpected change in market liquidity and individual stock returns, consistent with the prior studies. It indicates that the liquidity risk is recognized as an additional source of systematic risk in the Korean stock market. The result implies that the more sensitive a stock is to the unexpected change in market liquidity, the higher liquidity premium is required by the investors. Analysis of the monthly movement of liquidity in the Korean stock market reveals that the market liquidity and its unexpected change increased sharply around the foreign currency crisis and the global financial crisis. It also shows the increase of liquidity risk, the sensitivity of individual stock return to the unexpected change in market liquidity, at times of liquidity risk. Many incidents have been occurring that bring about turbulences in financial market after the global financial crisis, and one of the underlying causes is referred to as lack of liquidity in the financial market. This study provides to the finance literature evidence of liquidity risk functioning as an additional source of systematic risk at Korean stock market, and it finds out that the liquidity risk itself differs depending on the level of market liquidity. This study contributes to the extant literature by presenting an additional evidence of liquidity risk as an additional systematic risk in the Korean stock market based on different sample period encompassing a world financial crisis. In addition, it uses a different definition and measurement of liquidity risk than the previous study. Despite those differences, this study ascertains the liquidity risk as a source of systematic risk in the Korean stock market. The result indicates that liquidity risk must be taken into account along with well-known risk factors in estimating expected return from assets. Also, it needs to be noted that unusual movement of liquidity at times of financial crisis increases the systematic risk of stocks. 본 연구의 목적은 국내 주식시장을 대상으로 유동성위험(liquidity risk)이 개별 기업의 기대수익률을 설명하는 체계적 위험 요인으로 작용하고 있는지를 검증한다. 또한 외환위기와 세계금융위기와 같은 유동성 위기 기간에 시장유동성과 비기대 시장유동성 변동이 어떠한 양상을 보이는지를 살펴보고, 이 시기 유동성위험의 크기가 그렇지 않은 기간과 어떠한 차이를 나타내는지를 확인하고자 한다. 이를 위해 1992년∼2012년까지 한국증권거래소에 상장된 기업들 중 표본 선정 기준을 만족한 139,468 기업-월 표본을 대상으로 실증분석을 실시한 결과, 이전 연구에서 개별 주식의 기대수익률에 영향을 미치는 요인들로 확인된 시장베타, 기업규모, BE/ME ratio를 통제한 후에도 유동성위험 변수와 개별 주식 초과수익률 간에 유의한 양(+)의 상관관계가 있음을 확인하였다. 이는 비기대 시장유동성 변동에 민감한 주식일수록 높은 유동성 프리미엄을 요구하고 있음을 보여준다. 본 연구의 결과는 해외 연구와 일관되는 것으로 국내 주식시장에서도 유동성위험이 존재하며, 시장참여자들에 의해 체계적 위험 요인으로 평가되고 있음을 제시한다. 월별 시장유동성 및 비기대 시장유동성 변동 패턴을 살펴본 결과에서도 1997년 외환위기와 2007년 세계금융위기 당시 우리나라 주식시장에서도 시장유동성뿐만 아니라 비기대 시장유동성 변동이 급격하게 증가하였으며, 유동성위험도 함께 증가하는 것으로 나타났다.

녹내장

배성미 약업신문사 2001 의약정보 Vol.2001 No.6

각 약물의 Drug Use Evaluation에 의한 적정성 추구

배성미 한국병원약사회 2001 병원약사회지 Vol.18 No.4

임상약동학 자문에 의한 처방 및 모니터링 과오 예방

배성미 한국병원약사회 2003 병원약사회지 Vol.20 No.2

'협동적 쓰기' 교수가 초등 작문장애 학생의 쓰기표현력에 미치는 효과

배성미(Sung-mi, Bae),박현숙(Hyun-Sook, Park) 한국언어청각임상학회 2002 Communication Sciences and Disorders Vol.7 No.2

최근의 쓰기교수는 쓰기기술의 습득에만 치중하는것이 아니라 다른 구성원과의 역동적인 상호작용을 통해 쓰기에 필요한 전략들을 직접 수행하고 내면화하는 과정을 강조하고 있다. 이에 본 연구는 협동적 쓰기 교수가 초등 작문장애학생의 쓰기표현력에 미치는 영향을 알아보고자 하였다. 이를 위해 서울 시내의 초등학교 5-6학년 작문장애 아동 20명을 대상으로 15회기에 걸쳐 실험집단에게는 협동적 쓰기 교수를, 그리고 통제집단에게는 전통적인 쓰기 교수를 실시하였다. 두 집단에게 동일한 주제로 글을 쓰는 사전, 사후 검사를 실시하여 공분산 분석을 한 결과, 실험집단이 글의 내용, 글의 길이, 글의 정확도(철자, 띄어쓰기, 문장부호, 문법사용)에 있어서 유의하게 향상되었다. 이러한 결과는 작문하기에 협동적 쓰기 교수를 활용할 경우, 작문장애 학생의 쓰기표현력을 향상시킬 수 있을 뿐만 아니라 쓰기에 쉽게 친숙해질 수 있도록 유도하는 이점을 기대해 볼 수 있음을 시사한다. The collaborative writing is a method by which a student shares the actual process of composition with his/ her writing partner (s), and they alternate turns to complete the composition. A teacher , another student , or a group of student can be writing partner (s), and a teacher was chosen as the writing partner in this study. The purpose of this study was to test the effect s of the writing instruction by the collaborative writing on written expression ability in elementary student s with composition disabilities. For this purpose, 20 elementary student s with composition difficulties were selected (8 from 5th grade and 12 from 6th grade) to be divided into two groups, an experimental and a control. The two groups were trained for 7 weeks (15 40 - minutes sessions) through the stages of choosing a title, planning, writing, and revising their writing product s. In the stage of writing, the experimental group wrote the product collaboratively with a teacher and the control group wrote it individually. The written expression ability was evaluated by measuring story content s, story length, and story correctness using pre- and post - test . ANCOVA was used to analyze the collected data utilizing the pretest scores as covariates. The result s obtained from this study are summarized as follows : (1) A significant difference was found between the experimental and the control groups in story content s, showing significantly higher performance in the former group; (2) A significant difference was found between the two groups in story length, showing significantly longer performance in the experimental group; and (3) The experimental group showed significantly higher performance in story correctness, that is, spelling, spacing words, punctuation, and grammar (in total). In terms of grammar , however , significant differences were found between the two groups in modifier and word order , while no significant differences were found in auxiliary words, subject -predicate concord, tense, and conjunction. In conclusion, these result s imply that the written expression ability of student s with composition disabilities could be enhanced by providing them with composition instruction through the collaborative writing.

形態言語로서 Symbol과 色彩言語의 相關性 硏究

裵星美 한국조형교육학회 1992 造形敎育 Vol.0 No.8

When the man is recognized through visuality they are come from the selective and abstract courses. However, there exists a general rule among the man's subjectivities. The masscommunication is realized for such generality. Generality results from the potential impulse and desire of human beings and it is socialistic because it is the association and a common denominator which is accumulated according to his experience. The visual design which is a premise for the social communicative function should be substantially corresponded with the perceptive generality and also it should be created suitable to common experience or association. So far as the communication plays its obvious role, both association and symbol are important since the communication itself is a social behavior. The association has a common feature of a certain reaction with a lot of people and it has a meaning as a language which is generalized in connection with the tradition. This thesis can be obtained following conclusions as a result of the investigation of correlations between symbol and colorful language as a morphology. 1. The general association plays a role of powerful and colorful language and so it realizes the formal image and changes into quite different meanings. 2. In case it is related with the experience concretely, it rather depends upon the abstract sensibility of colors. 3. If the form itself has a firm image, conceptually, the influence on the colorful language is decreased. 4. If the form makes a strong visuality by itself e.g. a sharp form the influence on the colorful language is decreased. 5. If the associable generality of the form itself is decreased, the colorful language functions strongly, and so it forms whole image. 6. "Red" is quite stimulated, powerful, high in the associable ratio, works a concrete association and realizes a comprehensive concept. In this regard, it was able to infer that "Red" is a color which has many experiences. 7. The low

메탄올 자화성 Hyphomicrobium sp. A-12의 특성 및 단세포 단백질(SCP)의 생산

李啓瑚,裵星美 서울大學校 農科大學 1987 서울대농학연구지 Vol.12 No.1

126 methanol-utilizing microorganisms were isolated by enrichment techniques from the samples of soil, sewage, spoiled milk and decomposed sweet-radish pickles. One of them was selected to produce Single Cell Protein(SCP) and identified as a strain of genus Hyphomicrobium on the basis of taxonomical characteristics. The concentration of methanol affected the productivity. Hyphomicrobium A-12 well-adapted in 1%(v/v) methanol medium came to grow best in 1.6%(v/v). The growth was inhibited in higher than 2%(v/v). The optimal temperature and pH for growth were 30℃ and 7, respectively. The strain didn't necessarily require the growth factors, but 1%(w/v) yeast extract had a stimulating effect on its growth. The productivity was 6.5g dry cells/ℓ in batch culture with 1.6% methanol and the cell yield was 0.33gg-1. The oxygen consumption rate(QO2) was 6.1㎕/mg dry wt./hr when the substrate was methanol. The protein content of the cell was 72%(w/w) while the amino acid content was 54.8%. The nucleic acid content as RNA was 13%.