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RISS 인기검색어
- 검색키워드
- 주제어 : 1-p-coumaroyl β-D-glucoside (CG) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Van Anh Vo,Jae-Won Lee,Ji-Young Kim,Jun-Ho Park,Hee Jae Lee,Sung-Soo Kim,Yong-Soo Kwon,Wanjoo Chun 대한생리학회-대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.1
Hydroxycinnamic acids have been reported to possess numerous pharmacological activities such as antioxidant, anti-inflammatory, and anti-tumor properties. However, the biological activity of 1-p- coumaroyl β-D-glucoside (CG), a glucose ester derivative of p-coumaric acid, has not been clearly examined. The objective of this study is to elucidate the anti-inflammatory action of CG in lipopo-lysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In the present study, CG significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2 and the protein expression of iNOS and COX-2. CG also inhibited LPS-induced secretion of pro-inflammatory cytokines, IL-1β and TNF-α. In addition, CG significantly suppressed LPS-induced degradation of IκB. To elucidate the underlying mechanism by which CG exerts its anti-inflammatory action, involvement of various signaling pathways were examined. CG exhibited significantly increased Akt phosphorylation in a concentration-dependent manner, although MAPKs such as Erk, JNK, and p38 appeared not to be involved. Furthermore, inhibition of Akt/PI3K signaling pathway with wort-mannin significantly, albeit not completely, abolished CG-induced Akt phosphorylation and anti- inflammatory actions. Taken together, the present study demonstrates that Akt signaling pathway might play a major role in CG-mediated anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells.
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Van Ahn Vo,이재원,김지영,박준호,이희재,김성수,권영수,전완주 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.1
Hydroxycinnamic acids have been reported to possess numerous pharmacological activities such asantioxidant, anti-inflammatory, and anti-tumor properties. However, the biological activity of 1-pcoumaroylβ -D-glucoside (CG), a glucose ester derivative of p-coumaric acid, has not been clearlyexamined. The objective of this study is to elucidate the anti-inflammatory action of CG in lipopolysaccharide(LPS)-stimulated RAW264.7 macrophage cells. In the present study, CG significantlysuppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO)and PGE2 and the protein expression of iNOS and COX-2. CG also inhibited LPS-induced secretionof pro-inflammatory cytokines, IL-1β and TNF-α. In addition, CG significantly suppressed LPS-induceddegradation of IκB. To elucidate the underlying mechanism by which CG exerts its anti-inflammatoryaction, involvement of various signaling pathways were examined. CG exhibited significantly increasedAkt phosphorylation in a concentration-dependent manner, although MAPKs such as Erk, JNK, andp38 appeared not to be involved. Furthermore, inhibition of Akt/PI3K signaling pathway with wortmanninsignificantly, albeit not completely, abolished CG-induced Akt phosphorylation and antiinflammatoryactions. Taken together, the present study demonstrates that Akt signaling pathwaymight play a major role in CG-mediated anti-inflammatory activity in LPS-stimulated RAW264.7macrophage cells.
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