Antidiabetic Effect of Flavones from Cirsium japonicum DC in Diabetic Rats

Zhiyong Liao,Xiaoli Chen,Mingjiang Wu 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.3

Cirsium japonicum DC is a traditional Chinese herb used along with other herbs to treat hypertension, traumatic hemorrhage, inflammation, and renal cellular injury. Here, we isolated two flavones from Cirsium japonicum DC, pectolinarin and 5,7-dihydroxy-6,4’-dimethoxy flavone (DDMF), and investigated their antidiabetic effect in diabetic rats established by intravenous injection with streptozotocin followed by feeding with high-carbohydrate/high-fat diet. Both pectolinarin and DDMF showed antidiabetic effect in diabetic rats. However, FECJ, a mixture of pectolinarin and DDMF, is more effective than pectolinarin and DDMF in improving the plasma glucose, cholesterol and triglycerides levels in diabetic rats. The altered activities of glucose metabolism-related enzymes in diabetic rats were well reversed after flavone treatment. The plasma adiponectin level was greatly increased in diabetic rats treated with FECJ, while no obvious effect of the flavones on the dysregulated plasma insulin level and expressions of leptin and glucose transporter 4 (GLUT4) was observed. Our data indicated that the flavones improved adiponectin expression, accompanied by restoring of the dysregulated activities of the glucose metabolism-related enzymes, ultimately resulting in well improved glucose and lipid homeostasis. Thus, an antidiabetic effect of Cirsium japonicum DC was revealed in diabetic rats, suggesting the potential benefit of the Cirsium japonicum DC as an alternative in treating diabetes mellitus.

Magnetic Properties and Microstructure of DyAlCu-diffusion Sintered Nd-Fe-B Magnets

Chunfa Liao,Xun Zhou,Peng Jiang,Zhiyong Zeng,Lianghua Que 한국자기학회 2022 Journal of Magnetics Vol.27 No.2

The ability to improve the coercivity of sintered Nd-Fe-B diffused by Dy-Al-Cu alloy derived from electrolysis in a fluoride salt-oxide system was evaluated. The results show that with the increase in heat treatment time, the coercivity of the magnet firstly increased and then decreased. Holding at 900 ℃ for 4 h, tempering at low temperature for 3 h at 550 ℃, the coercivity of GBDPed magnet increased by 44.34 %, the remanence decreased by 1.26 %, the Dy-rich shell phase was recognizable, and the Nd-rich phase evenly distributed. Electron microscope analysis showed that when the GBDP time was longer than 4h, the diffusion of Dy from the shell phase to the matrix phase dominated, decreasing the coercivity with the increase in the diffusion time. The increase of Fe content in the grain boundary phase enhanced the exchange coupling between grains, which also reduced the coercivity of the GBDPed magnet. The infiltration of the matrix phase by excessive Dy and deterioration of (00L) texture of Nd-Fe-B resulted in the reduction of the remanence and the maximum energy product.

Influence of the Electrolytic Dy-Cu alloy on the Coercivity of Sintered Nd-Fe-B Magnet

Chun-fa Liao,Xun Zhou,Peng Jiang,Zhiyong Zeng,Lianghua Que 한국자기학회 2022 Journal of Magnetics Vol.27 No.4

The fluorine salt oxide molten-salt electrolytic Dy-Cu alloy was used as a grain boundary diffusion source instead of the doped Dy-Cu alloy. The microstructure and coercivity of the GBDPed magnets with the different diffusion times were studied. The results show that the coercivity increased with the increase in the GBDP time. The ability of the electrolytic Dy-Cu alloy to improve the coercivity of Nd-Fe-B is more advantageous than that of the doped Dy-Cu alloy. Microstructure analysis shows that the segregation and metal inclusion, a small amount of Dy2O3, and the poor synergy diffusion between Dy and Cu lead to the unsatisfactory performance of the doped Dy-Cu alloy to improve the coercivity. The diffusion rate and depth of the GBD source improved by replacing the doped alloy with an electrolytic alloy.

Security Analysis of the Whirlpool Hash Function in the Cloud of Things

( Wei Li ),( Zhiyong Gao ),( Dawu Gu ),( Chenyu Ge ),( Linfeng Liao ),( Zhihong Zhou ),( Ya Liu ),( Zhiqiang Liu ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.1

With the advancement and deployment of leading-edge telecommunication technologies for sensing and collecting, computing related information, Cloud of Things (CoTs) has emerged as a typical application platform that is envisioned to revolutionize the daily activities of human society, such as intelligent transportation, modern logistics, food safety, environmental monitoring, etc. To avoid any possible malicious attack and resource abuse, employing hash functions is widely recognized as one of the most effective approaches for CoTs to achieve message integrity and data authentication. The Whirlpool hash function has served as part of the joint ISO/IEC 10118-3 International Standard by the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC). In this paper, we propose an effective differential fault analysis on Whirlpool in the byte-oriented random fault model. The mathematical analysis and experimental results show that 8 random faults on average are required to obtain the current 512-bit message input of whirlpool and the secret key of HMAC-Whirlpool. Our work demonstrates that Whirlpool and HMAC-Whirlpool are both vulnerable to the single byte differential fault analysis. It provides a new reference for the security analysis of the same structure of the hash functions in the CoTs.

Security Analysis of the PHOTON Lightweight Cryptosystem in the Wireless Body Area Network

( Wei Li ),( Linfeng Liao ),( Dawu Gu ),( Chenyu Ge ),( Zhiyong Gao ),( Zhihong Zhou ),( Zheng Guo ),( Ya Liu ),( Zhiqiang Liu ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.1

With the advancement and deployment of wireless communication techniques, wireless body area network (WBAN) has emerged as a promising approach for e-healthcare that collects the data of vital body parameters and movements for sensing and communicating wearable or implantable healthful related information. In order to avoid any possible rancorous attacks and resource abuse, employing lightweight ciphers is most effective to implement encryption, decryption, message authentication and digital signature for security of WBAN. As a typical lightweight cryptosystem with an extended sponge function framework, the PHOTON family is flexible to provide security for the RFID and other highly-constrained devices. In this paper, we propose a differential fault analysis to break three flavors of the PHOTON family successfully. The mathematical analysis and simulating experimental results show that 33, 69 and 86 random faults in average are required to recover each message input for PHOTON-80 /20/16, PHOTON-160/36/36 and PHOTON-224/32/32, respectively. It is the first result of breaking PHOTON with the differential fault analysis. It provides a new reference for the security analysis of the same structure of the lightweight hash functions in the WBAN.

Security Analysis of the Khudra Lightweight Cryptosystem in the Vehicular Ad-hoc Networks

( Wei Li ),( Chenyu Ge ),( Dawu Gu ),( Linfeng Liao ),( Zhiyong Gao ),( Xiujin Shi ),( Ting Lu ),( Ya Liu ),( Zhiqiang Liu ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.7

With the enlargement of wireless technology, vehicular ad-hoc networks (VANETs) are rising as a hopeful way to realize smart cities and address a lot of vital transportation problems such as road security, convenience, and efficiency. To achieve data confidentiality, integrity and authentication applying lightweight cryptosystems is widely recognized as a rather efficient approach for the VANETs. The Khudra cipher is such a lightweight cryptosystem with a typical Generalized Feistel Network, and supports 80-bit secret key. Up to now, little research of fault analysis has been devoted to attacking Khudra. On the basis of the single nibble-oriented fault model, we propose a differential fault analysis on Khudra. The attack can recover its 80-bit secret key by introducing only 2 faults. The results in this study will provides vital references for the security evaluations of other lightweight ciphers in the VANETs.

3D PIC Method for Modeling and Simulating the Beam Transport System of a Linear Induction Accelerator

Yang Changhong,Meng Lin,Liu Da Gang,Zhang Kaizhi,Liao Shuqing,Dai Zhiyong 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61

Firstly, the method of combining the finite difference time domain with particle-in-cell code is used for simulating and modeling a accelerated section of the LIA, and on this basis, the numerical simulation of the solenoid coils and steering coils in accelerated section are completed by writing independent calculation module of magnetic components ,then on the platform of the MPICH2 message passing system, a proper method for parallel computing of more accelerate sections is provided and solved LIA's great scale problems. Finally, the 18 accelerated sections was simulated by the software, and compared with the envelope diagram of documents, which proved the correctness of the method used.

Evaluate Dry Deposition Velocity of the Nitrogen Oxides Using Noah-MP Physics Ensemble Simulations for the Dinghushan Forest, Southern China

Qi Zhang,Ming Chang,Shengzhen Zhou,Weihua Chen,Xuemei Wang,Wenhui Liao,Jianing Dai,ZhiYong Wu 한국기상학회 2017 Asia-Pacific Journal of Atmospheric Sciences Vol.53 No.4

There has been a rapid growth of reactive nitrogen (Nr) deposition over the world in the past decades. The Pearl River Delta region is one of the areas with high loading of nitrogen deposition. But there are still large uncertainties in the study of dry deposition because of its complex processes of physical chemistry and vegetation physiology. At present, the forest canopy parameterization scheme used in WRF-Chem model is a single-layer “big leaf” model, and the simulation of radiation transmission and energy balance in forest canopy is not detailed and accurate. Noah-MP land surface model (Noah-MP) is based on the Noah land surface model (Noah LSM) and has multiple parametric options to simulate the energy, momentum, and material interactions of the vegetation-soil-atmosphere system. Therefore, to investigate the improvement of the simulation results of WRF-Chem on the nitrogen deposition in forest area after coupled with Noah-MP model and to reduce the influence of meteorological simulation biases on the dry deposition velocity simulation, a dry deposition single-point model coupled by Noah- MP and the WRF-Chem dry deposition module (WDDM) was used to simulate the deposition velocity (Vd). The model was driven by the micro-meteorological observation of the Dinghushan Forest Ecosystem Location Station. And a series of numerical experiments were carried out to identify the key processes influencing the calculation of dry deposition velocity, and the effects of various surface physical and plant physiological processes on dry deposition were discussed. The model captured the observed Vd well, but still underestimated the Vd. The self-defect of Wesely scheme applied by WDDM, and the inaccuracy of built-in parameters in WDDM and input data for Noah-MP (e.g. LAI) were the key factors that cause the underestimation of Vd. Therefore, future work is needed to improve model mechanisms and parameterization.