Regulation of Antiarrhythmic Drug Propafenone Effects on the C-type KV1.4 Potassium Channel by PHo and K+

Zhiquan Wang,Jianjun Li,Xuejun Jiang,Xuejun Jiang,Neng Wang,Shimin Wang 대한의학회 2009 Journal of Korean medical science Vol.24 No.1

The effects of the antiarrhythmic drug propafenone at c-type kv1.4 channels in Xenopus laevis oocytes were studied with the two-electrode voltage-clamp techinique. Defolliculated oocytes (stage V-VI) were injected with transcribed cRNAs of ferret Kv1.4△N channels. During recording, oocytes were continuously perfused with control solution or propafenone. Propafenone decreased the currents during voltage steps. The block was voltage-, use-, and concentration- dependent manners. The block was increased with positive going potentials. The voltage dependence of block could be fitted with the sum of monoexponential and a linear function. Propafenone accelerated the inactivate of current during the voltage step. The concentration of half-maximal block (IC50) was 121 μM/L. With high, normal, and low extracellular potassium concentrations, the changes of IC50 value had no significant statistical differences. The block of propafenone was PH- dependent in high-, normal- and low- extracellular potassium concentrations. Acidification of the extracellular solution to PH 6.0 increased the IC50 values to 463 μM/L, alkalization to PH 8.0 reduced it to 58 μM/L. The results suggest that propafenone blocks the kv1.4 N channel in the open state and give some hints for an intracellular site of action.

Microsatellite Markers Linked to Quantitative Trait Loci Affecting Fatness in Divergently Selected Chicken Lines for Abdominal Fat

Zhang, Hui,Wang, Shouzhi,Li, Hui,Yu, Xijiang,Li, Ning,Zhang, Qin,Liu, Xiaofeng,Wang, Qigui,Hu, Xiaoxiang,Wang, Yuxiang,Tang, Zhiquan Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.10

Abdominal fat characters are complex and economically important in the poultry industry. Their selection may benefit from the implementation of marker-assisted selection (MAS). The objective of this study was to identify the markers linked to QTL responsible for fatness traits. The Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF) were used in the study. A total of 596 individuals from the divergent tails from the 6th to the 10th generations were genotyped at 23 microsatellite markers on chromosome 1. The differences of allele frequencies of all marker alleles between the divergent tails across the five generations were recorded. The allele frequencies of five markers, including LEI0209, LEI0146, MCW0036, ADL328 and MCW0115, had significant differences between the two tails in all five generations. The resulting p-values using Fisher's exact test on eleven markers, containing MCW248, MCW0010, MCW0106, LEI0252, LEI0068, MCW0018, MCW0061, LEI0088, MCW200, MCW283 and ROS0025, had a decreasing tendency from the 6th to the 10th generation. Statistical analysis showed that polymorphisms of the eight markers, including LEI0209, LEI0146, ROS0025, MCW0115, MCW0010, MCW0036, MCW283, ADL328, were significantly (p<0.0011) or suggestively (p<0.05) associated with abdominal fat content (AFW and AFP) across generations. It is concluded that the eight markers could be associated with the QTL affecting the deposition of abdominal fat in broiler chickens.

The Relationship Between the Fruit Root Lifespan and Respiration Intensity

Zhiquan Mao,Yanli Hu,Jianghong Zhang,Jiayan Wang,Huairui Shu 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

The Research of Relationship between SICSFCL and Distance Relay Protection of Power Grid

Wang, Jianzhong,Cui, Jibin,Xiong, Zhiquan,Zi, Meirong The Korean Institute of Electrical Engineers 2012 The Journal of International Council on Electrical Vol.2 No.2

A Saturated Iron Core Superconducting Fault Current Limiter (SICSFCL) provides a powerful fault current limitation in high voltage and high capacity power grid. A 35kV/90MVA SICSFCL was installed in a 35 kV network for live-grid operation, in January 2008 at Puji substation, Kunming, China. With deep research on SICSFCL, the matching problem between SICSFCL and relay protection currently needs to be solved. This paper analyzes the influence that SICSFCL brings to the distance relay protection which is used widely in high voltage power grid, and considering the characteristics of microcomputerbased protection, this paper proposes a new algorithm to eliminate the influence.

Fair Resource Allocation with QoS Guarantee in Secure Multiuser TDMA Networks

Bai, Zhiquan,Wang, Tongtong,Ma, Piming,Ma, Yanbo,Kwak, Kyungsup WILEY INTERSCIENCE 2018 WIRELESS COMMUNICATIONS AND MOBILE COMPUTING Vol.2018 No.-

<P>We investigate a secure multiuser time division multiple access (TDMA) system with statistical delay quality of service (QoS) guarantee in terms of secure effective capacity. An optimal resource allocation policy is proposed to minimize the <TEX>$ \beta $</TEX> -fair cost function of the average user power under the individual QoS constraint, which also balances the energy efficiency and fairness among the users. First, convex optimization problems associated with the resource allocation policy are formulated. Then, a subgradient iteration algorithm based on the Lagrangian duality theory and the dual decomposition theory is employed to approach the global optimal solutions. Furthermore, considering the practical channel conditions, we develop a stochastic subgradient iteration algorithm which is capable of dynamically learning the intended wireless channels and acquiring the global optimal solution. It is shown that the proposed optimal resource allocation policy depends on the delay QoS requirement and the channel conditions. The optimal policy can save more power and achieve the balance of the energy efficiency and the fairness compared with the other resource allocation policies.</P>

장예모의 인상(印象) 시리즈 <인상유삼저>에 관한 연구

왕지권,WANG, Zhiquan 성균관대학교 트랜스미디어연구소 2018 트랜스- Vol.5 No.-

장예모 감독의 작품 <인상유삼저>가 기존의 공연들과 차별화되는 가장 큰 특징은 무대공간의 활용에 있다. 인상시리즈의 무대는 세트장과 대자연과 결합하여 전통적인 무대공연양식에서 탈피하여 자연환경을 무대배경으로 완성하였다. 또한 자신만의 특색 있는 미적 감각과 자연공간을 조화시켜 해당 지역문화의 특색을 반영해 내었다. <인상유삼저>는 실제 자연경관을 배경으로 하는 단순한 산수공연이 아니라 자연적인 색채와 공간이 조화를 이루어 나타내는 인간과 자연사이의 친환경적 개념에서 비롯되어 해당 지역사회의 문화산업적 요소를 홍보하는 기능으로 작용하기도 하였다. 본 연구는 문화인류학자 홀의 프록세믹스(proxemics) 개념과 친환경적 측면에서 <인상유삼저>를 분석하였다. <인상유삼저>는 자연환경을 배경으로 하는 실경산수공연의 형식으로 연출하며 해당 지역사회의 문화와 자연적 특성을 최대한 보존하는 동시에 현지문화산업의 홍보측면에도 기여하였다. <인상유삼저>는 실경산수공연으로서 인간과 자연을 성공적으로 융합하여 환경을 보존하였다는 데에도 의의를 갖고 있다. What distinguishes Impression Liu Sanjie, directed by Zhang yimou from other stage performances lies in its use of space. Firstly, it breaks the regular way of performing in a limited theater space but instead, impression Liu sanjie bases the stage activities on the real nature scenery. Secondly, it promotes the local culture by combining the unique color effect of the particular nature scenery with its use of the scenery's natural space, with an aesthetic precision. In another word, Impression Liu Sanjie is not a simple performance set on the natural scenery but more of a promotion to the local culture, through the concept of "environment friend" between human and nature, which is brought by mixing the unique color of natural scenery and its natural space. This research analyzes the Impression Liu Sanjie's use of space basing on Proxemics by Edward T Hall. Impression Liu Sanjie adapts its character from a folk tale, employs the form of natural scenery performance, and at the same time to the largest extent throughout its creating process respects the local culture and its natural space. As a result, the performance presents the idea of "environmentally friendly".

바티니에프 기본원리를 통해 본 양식 태극권에 관한 연구

왕지권,Wang, Zhiquan 성균관대학교 트랜스미디어연구소 2020 트랜스- Vol.8 No.-

본 연구는 태극권 움직임에서 신체의 이완방법을 개발하기 위해 바티니에프 기본원리를 적용하여 태극권 움직임의 원리를 분석하였다. 이 연구과정을 통해 태극권과 바티니에프의 신체 움직임이 일맥상통한다는 것을 알 수 있었다. 첫째, 태극권과 바티니에프의 신체 움직임 철학 각도에서 살펴보면 두 기법의 궁극적인 목표는 모두 정신과 신체의 통합이다. 즉 동양의 심신일원론(心身一元論)과 서양의 신체자각(Body Awareness)이 일맥상통하였다. 둘째, 바티니에프가 제시한 호흡지지의 측면에서 살펴보면 두 기법은 모두 호흡을 통해 신체를 자연스럽게 움직이게 하고 각 부위를 이완시킨다. 태극권에서 기(氣)는 생명의 바탕이며 신(身)의 힘이다. 즉, 태극권의 호흡은 몸과 마음(Body- Mind)을 소통, 조화, 융화시킬 수 있는 것이다. 다시 말해서 태극권의 호흡은 정신적인 융합을 통하여 이루어지며 움직임에 영향을 주었다. 바티니에프의 호흡지지도 마찬가지다. 바티니에프의 호흡은 모든 관점에서 움직임에 영향을 주고 호흡은 몸의 내부와 외부의 형태를 모두 변화시킨다고 한다. 셋째, 바티니에프가 제시한 중심부지지의 측면에서 살펴보면 두 기법은 모두 중심을 강조하였다. 중심 지지를 의식하면서 움직이면 몸의 표면적인 근육보다는 좀 더 깊은 근육을 사용할 수 있으며 이를 통해 강하고 유연한 움직임을 가능하게 하였다. 태극권의 기침단전(氣沉丹田)은 의식적으로 복식호흡을 사용하고 힘을 중심으로 모은다. 이러한 운동을 할 때 중심은 더 안정되고 호흡 역시 순조로워진다. 넷째, 바티니에프 기본원리에서 제시한 회전적 요인의 측면에서 살펴보면 모두 회전을 사용한 움직임을 통해 신체 이완이라는 목적을 이루게 된다. 바티니에프의 회전적 요인은 축을 중심으로 3차원적으로 움직이는 관절운동이라는 특성을 인지함으로써 동작을 더욱 쉽게 하고 자유롭게 할 수 있었다. 태극권도 마찬가지다. 태극권은 원형과 나선형(Spiral Movement)의 움직임을 통해서 공간을 최대한 접근하고 매끄럽게 흐름을 전환해서 이완이라는 목적을 이루게 되었다. 다섯 번째, 코헨(Bonnie Bainbridge Cohen)의 Body-Mind Centering Work 이론을 토대로 바티네에프가 정립한 발달 모형의 각도에서 살펴보면 태극권의 움직임의 발전과정과 발달 모형에서 제시한의 호흡, 중심-말초부 연결 / 중앙 반사, 머리- 꼬리뼈 연결 / 척추의 움직임, 상체-하체 연결 / 상응하는 움직임, 신체의 반쪽 연결 / 동종 편측 연결, 교차 측면 연결 / 대측 연결 모두 일맥상통함을 알 수 있었다. 즉 태극권은 호흡을 통해 에너지를 중심으로 모으고, 요추를 통해 상체와 하체를 연결하며 움직임이 발전할 때 동종 편측 연결뿐만 아니라 교차 측면 연결을 할 수 있다. 이러한 연구를 통해 무용의 움직임을 자연스럽게 표현하고, 신체 자각을 토대로 중심축과 관절, 및 균형을 이용한 신체의 움직임 원리를 분석해낼 수 있었다. This research is based on using Bartenieff Fundamentals to analyze the fundamentals of Tai Chi Chuan's movements in order to develop the methods of relaxation from Tai Chi Chuan's principle movement movements It also shows that the two techniques have commonalities in many ways. First of all, taking a philosophical approach on the body movements of Tai Chi Chuan and Bartenieff, for both methods the ultimate goal is the integration of mind and body. In other words, there is a thread of connection between the East's body and mind monism and the west's Body Awareness. Secondly, looking at it from a Breath Support standpoint as used in the Bartenieff method, the two methods both use the breathing to naturally move the body and relax the body. In Tai Chi Chuan the Breath is the basis of life and the strength of the Body. So the breathing of Tai Chi chuan is what makes body and mind communicate, harmonize and integrate. In other words, Breathing in Tai Chi is realized through mental fusion and affects the movements. This is the same as the Breath Support of Bartenieff. It is said that in every aspect the Breath Support of Bartenieff influences the movement and changes both the inner and outer form of the body. Thirdly, looking at the Core Support used in the Bartenieff method, both methods emphasize core. At the same time of moving and being conscious of one's core, the usage of muscles can be deeper rather than superficial and this enables strong and flexible movement. In Tai Chi Chuan abdominal muscles used when one coughs are consciously engaged through abdominal breathing and so strength is collected in the core. When one exercises like that the core becomes more stable and breathing becomes more smooth. Fourthly, analyzing the Rotary Factor used in the Bartenieff Fundamentals, they both use rotary movement to reach the goal of physical relaxation. The rotation factor of Bartenieff allows movement to be easier and more free because of the characteristic of joint exercise where the center axis moved in three dimensions, this is the same in Tai Chi chuan. According to Tai Chi chuan's circle and Spiral Movements, it can achieve the relaxation through switching into a seamless flow and access space as much as possible. Finally, when looking at Developmental Patterning through Bonnie Bainbridge Cohen's Body-Mind Centering Work theory, presented from Bartenieff developmental model are similar with the developmental process of Tai Chi chuan Breath, Core-Distal Connectivity/Navel Radiation, Head-Tail Connectivity/Spinal Movement, Upper-Lower Connectivity/Homologous, Body-Half Connectivity/Homo-Lateral Connectivity, Cross-Lateral Connectivity/Contra-Lateral Connectivity. They are all similar. In other words, in Tai Chi Chuan energy is gathered in the core through breathing, upper and lower body are connected through the spine, not only homo-laterally but also cross-laterally. Through this study the expression of the dance movements can be more natural. Additionally based on the Body Awareness balance usage of the central axis, joints and body can develop the relax technique.

Principle and Design of a Novel Lorenz Force Type Bearingless Motor with Single-Axis Actively Regulated Capability

Qiang, Ding,Zhiquan, Deng,Xiaolin, Wang,Guyu, Wu,Tuocheng, Ni The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.5

Analysis and Optimization of Rotor-twisted Structure for 12/10 Alternate Poles Wound FSPM Machine for Electric Vehicles

Xie, De'e,Wang, Yu,Deng, Zhiquan Journal of International Conference on Electrical 2013 Journal of international Conference on Electrical Vol.2 No.3

Fault-tolerant capability, wide speed range and overload capability are required in electric motors used in electric vehicles. In this paper, based on the analysis of the all poles wound and alternate poles wound flux-switching permanent-magnet machines, an optimization method is studied to reduce torque ripple. The method takes account of both flux-leakage and cogging torque. The simulation result shows that the method can reduce the torque ripple effectively. This study lays the foundation for the further application of FSPM in electric vehicles.

Assimilating AOD retrievals from GOCI and VIIRS to forecast surface PM_2.5 episodes over Eastern China

Pang, Jiongming,Liu, Zhiquan,Wang, Xuemei,Bresch, Jamie,Ban, Junmei,Chen, Dan,Kim, Jhoon Elsevier 2018 Atmospheric environment Vol.179 No.-

<P><B>Abstract</B></P> <P>In this study, Geostationary Ocean Color Imager (GOCI) AOD and Visible Infrared Imaging Radiometer Suite (VIIRS) AOD data were assimilated to forecast surface PM<SUB>2.5</SUB> concentrations over Eastern China, by using the three–dimensional variational (3DAVR) data assimilation (DA) system, to compare DA impacts by assimilating AOD retrievals from these two types of satellites. Three experiments were conducted, including a CONTROL without the AOD assimilation, and GOCIDA and VIIRSDA with the assimilation of AOD retrievals from GOCI and VIIRS, respectively. By utilizing the Weather Research and Forecasting with Chemistry (WRF/Chem) model, 48-h forecasts were initialized at each 06 UTC from 19 November to 06 December 2013. These forecasts were evaluated with 248 ground-based measurements from the air quality monitoring network across 67 China cities. The results show that overall the CONTROL underestimated surface PM<SUB>2.5</SUB> concentrations, especially over Jing–Jin–Ji (JJJ) region and Yangtze River Delta (YRD) region. Both the GOCIDA and VIIRSDA produced higher surface PM<SUB>2.5</SUB> concentrations mainly over Eastern China, which fits well with the PM<SUB>2.5</SUB> measurements at these eastern sites, with more than 8% error reductions (ER). Moreover, compared to CONTROL, GOCIDA reduced 14.0% and 6.4% error on JJJ region and YRD region, respectively, while VIIRSDA reduced respectively 2.0% and 13.4% error over the corresponding areas. During the heavy polluted period, VIIRSDA improved all sites within YRD region, and GOCIDA enhanced 84% sites. Meanwhile, GOCIDA improved 84% sites on JJJ region, while VIIRSDA did not affect that region. These geographic distinctions might result from spatial dissimilarity between GOCI AOD and VIIRS AOD at time intervals. Moreover, the larger increment produced by AOD DA under stable meteorological conditions could lead to a longer duration (e.g., 1–2 days, > 2 days) of AOD DA impacts. Even though with AOD DA, surface PM<SUB>2.5</SUB> concentrations were still underestimated clearly over heavy polluted periods. And 3% sites performed worse, where low PM<SUB>2.5</SUB> values were observed and CONTROL performed well. With this study, the results indicate that AOD DA can partially improve the accuracy of PM<SUB>2.5</SUB> forecasts. And the obvious geographic differences on forecasts emphasize the potential and importance of combining AOD retrievals from GOCI and VIIRS into data assimilation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AOD retrievals from two types of satellites were assimilated solely. </LI> <LI> Assimilating different AOD produced prominent geographic differences on forecast. </LI> <LI> Larger increment under stable meteorological conditions lead to a longer duration. </LI> <LI> The results emphasize the potential of combining different AOD retrievals. </LI> </UL> </P>