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Response of Water Tetramer to Intense Femtosecond Laser Pulses
Zhiping Wang,Xuefen Xu,Chaoyi Qian,Yanbiao Wang,Xu Wang 한국광학회 2017 Current Optics and Photonics Vol.1 No.4
We theoretically study the dynamics of water tetramer in intense femtosecond laser pulses with differentfrequencies. The simulations are carried out by incorporating the molecular dynamics method non-adiabaticallyinto the time-dependent local-density approximation (TDLDA-MD). Three typical scenarios of watertetramer including the normal vibration with enlarged OH bonds, free OH bonds breaking and the pureCoulomb explosion are presented by investigating the electronic and ionic dynamics. The result indicatesthat the ionization is enhanced and the corresponding fragmentation effect as well as the damping of thedipole moment are found more notably when increasing the laser frequency especially when the frequencyfalls in the resonant region of the absorption spectra. The study of the level depletion reveals that theratio of the emission amount from different levels can be controlled by changing the laser frequencyreferring to the Keldysh parameter.
Qian Wu,Hui Wang,Juanjuan Wu,Dagang Wang,Yongli Wang,Lei Zhang,Zhiping Huang,Deyue Yu 한국식물학회 2015 Journal of Plant Biology Vol.58 No.4
The evaluation and use of endogenous soybean genes is an effective strategy to minimize the yield losses caused by insects. Allene oxide cyclase (AOC) catalyzes the most important step in the biosynthesis of jasmonate (JA), which plays a crucial role in plant defense against insects. In this study, the role of GmAOC3 in plant insect resistance was evaluated. Real-time PCR results indicate that GmAOC3 was uniquely and rapidly activated and attained peak expression in leaves after attack by the common cutworm (CCW). In insect bioassays, transgenic lines overexpressing GmAOC3 were significantly less damaged than wild-type plants, and the relative growth rate of CCW fed with leaves from transgenic lines was significantly lower than that of CCW fed with leaves from wild-type plants. Electron microscopy revealed that the density of leaf trichomes in transgenic lines overexpressing GmAOC3 was greater than that in wild-type tobacco. Several physiological and morphological indicators, including JA, phenolic content and the relative expression levels of the putrescine N-methyltransferase (PMT) and proteinase inhibitor (PI) genes, phenylalanine ammonia lyase (PAL) activity and volatile substances, increased in the transgenic plants overexpressing GmAOC3. Our findings indicate that GmAOC3 plays an important role in soybean resistance to CCW and can be used as a resource for plant breeding.
Xuan Zhang,ZhiPing Mao,Qian Wu,LinPing Zhang 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.3
In this report, hexakis (4-nitrophenoxy) cyclotriphosphazene (HNCP) and ethylene–octene copolymer grafted-maleic anhydride (POE-g-MA) were blended with pure PET together. The fire retardant ability and thermal stability of PET/HNCP/POE-g-MA were investigated respectively. The results indicated that HNCP and POE-g-MA had a synergic effect on the dripping resistance of PET besides the enhancement in flame retardancy to a certain degree. LOI values of the polymers with both POE-g-MA and 10 wt%HNCP were higher than that of pure PET and no drips just containing 1 wt%POE-g-MA. The reason was that HNCP could be well dispersed in PET when POE-g-MA was added, forming a more effective char layer and preventing dripping of polymers. Indeed, the morphology of charred residue of PET/HNCP/POE-g-MA showed that a porous protective layer with a dense surface was formed. The thermogravimetric analysis revealed that addition of HNCP improved the thermal stability and the yield of char residue of the PET/POE-g-MA systems. Based on a series of experiment results, the synergistic effect of HNCP and POE-g-MA on the anti-dripping of PET was also discussed. In the PET/HNCP/POE-g-MA system, POE-g-MA played a role of compatibilizer. The improved compatibility and dispersion provided the composite with the ideal flame retardancy, thermal stability and anti-dripping property.
Jing Liu,Yanhang Gao,Xianbo Wang,Zhiping Qian,Jinjun Chen,Yan Huang,Zhongji Meng,Xiaobo Lu,Guohong Deng,Feng Liu,Zhiguo Zhang,Hai Li,Xin Zheng 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.2
Purpose: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneousascitic infection (SAI) in patients with acute decompensated cirrhosis. Materials and Methods: We retrospectively analyzed 432 acute decompensated cirrhotic patients with culture-positive SAI from11 teaching hospitals in China (January 2012 to May 2018). A Cox proportional hazards model analysis was conducted to identifyindependent predictors of 28-day mortality. Results: A total of 455 strains were isolated from 432 ascitic culture samples. Gram-negative bacteria (GNB), gram-positive bacteria(GPB), and fungi caused 52.3, 45.5, and 2.2% of all SAI episodes, respectively. Episodes were classified as nosocomial (41.2%), healthcare-related (34.7%), and community-acquired (24.1%). Escherichia coli (13.4%) and Klebsiella pneumoniae (2.4%) were extendedspectrumβ-lactamase producing isolates. The prevalence of methicillin-resistant Staphylococcus aureus was 1.1%. Ceftazidime,cefepime, aztreonam, and amikacin were recommended as first-line antibiotics agents for non-MDR GNB infections; piperacillin/tazobactam and carbapenems for MDR GNB in community-acquired and healthcare-related or nosocomial infections, respectively;and vancomycin or linezolid for GPB infections, regardless of drug-resistance status. Multivariate analysis revealed days ofhospital stay before SAI, upper gastrointestinal bleeding, white blood cell count, alanine aminotransferase, serum creatinine concentration,total bilirubin, and international normalized ratio as key independent predictors of 28-day mortality. Conclusion: MDR pathogens and antibiotic strategies were identified in patients with acute decompensated cirrhosis with culture-positive SAI, which may help optimize therapy and improve clinical outcomes.
Uniform Side Illumination Generated from LEDs Arranged by an Annealing Algorithm
Xu Wang,Panling Lei,Chaoyi Qian,Zhiping Wang,Xuefen Xu,Zhouping Su 한국광학회 2022 Current Optics and Photonics Vol.6 No.3
Given a cubic space, it is easy to uniformly illuminate the floor with light sources placed on top. However, little has been reported about uniform illumination on walls with the same configuration of light sources. Here we present a luminaire consisting of nine light-emitting diodes (LEDs) with perfect Lambertian distribution, placed on the top as a 3 × 3 rectangular LED array. The distances between LEDs and tilt angles of each individual LED are adjustable and optimized by an annealing algorithm. After optimization, the array produces a rectangular illumination pattern on one wall with a uniformity of about 89%. Analysis shows that the tilt angles of individual LEDs are key parameters for uniform side illumination. In a scenario that is more practical, the tilt angles of all the LEDs are set to be the same, only decreasing the uniformity to 83%.
Lim, Chae-Seok,Kang, Xi,Mirabella, Vincent,Zhang, Huaye,Bu, Qian,Araki, Yoichi,Hoang, Elizabeth T.,Wang, Shiqiang,Shen, Ying,Choi, Sukwoo,Kaang, Bong-Kiun,Chang, Qiang,Pang, Zhiping P.,Huganir, Richar Cold Spring Harbor Laboratory Press 2017 Genes & development Vol.31 No.6
<P>Rapid advances in genetics are linking mutations on genes to diseases at an exponential rate, yet characterizing the gene mutation-cell behavior relationships essential for precision medicine remains a daunting task. More than 350 mutations on small GTPase BRaf are associated with various tumors, and similar to 40 mutations are associated with the neurodevelopmental disorder cardio-facio-cutaneous syndrome (CFC). Wedeveloped a fast cost-effective lentivirus-based rapid gene replacement method to interrogate the physiopathology of BRaf and similar to 50 disease-linked BRaf mutants, including all CFC-linked mutants. Analysis of simultaneous multiple patch-clamp recordings from 6068 pairs of rat neurons with validation in additional mouse and human neurons and multiple learning tests from 1486 rats identified BRaf as the key missing signaling effector in the common synaptic NMDA-R-CaMKII-SynGap-Ras-BRaf-MEK-ERK transduction cascade. Moreover, the analysis creates the original big data unveiling three general features of BRaf signaling. This study establishes the first efficient procedure that permits large-scale functional analysis of human disease-linked mutations essential for precision medicine.</P>