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Zhifang Tong,Congcong Xu,Jiaxing Wang,Zhiheng Jia 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.1
Herein, stainless-steel slag was used to prepare glass–ceramics. The effects of the MgO content on the occurrence, distributionstate, and migration behavior of Cr in glass–ceramics as well as glass properties were systematically studied. Results revealedthat in the nucleation stage, the number of Cr-spinel (Cr spinel) nanocrystals initially increased and then decreased with theincreasing MgO content. In the crystallization stage, the diopside crystal phase considered Cr-spinel nanocrystals asheterogeneous nuclei, which gradually nucleated and grew. Transmission electron microscopy and X-ray photoelectronspectroscopy analyses showed that part of Cr in the spinel migrated into the diopside lattice and some other parts remainedin the Cr spinel wrapped by the diopside. Cr in the glass phase also diffused and migrated into the diopside lattice with theformation of diopside crystals. When the MgO content was 12.3 wt.%, 97.33 wt.% of the total amount of Cr was observedin the diopside crystal phase and the leaching concentration of Cr in the glass–ceramics was only 0.006 mg/L. The compressivestrength of the glass–ceramics was 261.7 MPa, and the Vickers hardness was 1007.7 HV. The research results providetheoretical and technical support for strengthening Cr fixation and realizing harmless and high-value utilization of stainlesssteelslag.
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Xylazole inhibits NO-cGMP pathway in fetal rat nerve cells
Xinyu Wang,Yue Wu,Lin Liu,Hui Bai,Zhiheng Zhang,Mingchao Zhao,Tianwen Ma,Xiaopeng Song,Lina Jia,Liangyu Lv,Yue Yu,Xinyu Xu,Hong Chen,Li Gao 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1
Background: Xylazole (Xyl) is a veterinary anesthetic that is structurally and functionally similar to xylazine. However, the effects of Xyl in vitro remain unknown. Objectives: This study aimed to investigate the anesthetic mechanism of Xyl using fetal rat nerve cells treated with Xyl. Methods: Fetal rat nerve cells cultured for seven days were treated with 10, 20, 30, and 40 μg/ mL Xyl for 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min. Variations of amino acid neurotransmitters (AANTs), Nitric oxide-Cyclic GMP (NO-cGMP) signaling pathway, and ATPase were evaluated. Results: Xyl decreased the levels of cGMP and NO in nerve cells. Furthermore, Xyl affected the AANT content and Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity in nerve cells. These findings suggested that Xyl inhibited the NO-cGMP signaling pathway in nerve cells in vitro. Conclusions: This study provided new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.
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