A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo.

Zhang, Yong,Shaik, Ahmad Ali,Xing, Chengguo,Chai, Yubo,Li, Li,Zhang, Jinhui,Zhang, Wei,Kim, Sung-Hoon,L?, Junxuan,Jiang, Cheng M. Nijhoff ; Kluwer Academic Publishers 2012 Investigational new drugs Vol.30 No.5

<P>Targeting androgen receptor (AR) signaling with agents distinct from current antagonist drugs remains a rational approach to the prevention and treatment of prostate cancer (PCa). Our previous studies have shown that decursin and isomer decursinol angelate (DA), isolated from the Korean medicinal herb Angelica gigas Nakai, interrupt AR signaling and possess anti-PCa activities in vitro. In the LNCaP PCa cell model, these pyranoccoumarin compounds exhibit properties distinct from currently used antagonists (e.g., Casodex). However, both are rapidly de-esterified to decursinol, a partial AR agonist. We report here that a synthetic decursin analog, decursinol phenylthiocarbamate (DPTC), has greater in vivo stability than the parent compounds. DPTC-decursinol conversion was undetectable in mice. Furthermore, in LNCaP cells, DPTC decreased prostate specific antigen (PSA) expression, down-regulated AR abundance and mRNA and inhibited AR nuclear translocation. The effect of DPTC on AR and PSA mRNA and protein abundance was also observed in VCaP cells expressing wild type AR. DPTC inhibited growth of both PCa cell lines through G(1) cell cycle arrest and apoptosis, as did decursin and DA. Furthermore, i.p. administration of DPTC for 3 weeks suppressed the expression of AR target genes probasin and Nkx3.1 in mouse prostate glands. Overall, our data suggest that DPTC represents a prototype lead compound for development of in vivo stable and active novel decursin analogs for the prevention or therapy of PCa.</P>

Imaging Anatomy of Waldeyer's Ring and PET/CT and MRI Findings of Oropharyngeal Non-Hodgkin's Lymphoma

Zhang, Chun-Xing,Liang, Long,Zhang, Bin,Chen, Wen-Bo,Liu, Hong-Jun,Liu, Chun-Ling,Zhou, Zheng-Gen,Liang, Chang-Hong,Zhang, Shui-Xing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: This study was conducted to analyze positron emission tomography (PET) / computed tomography (CT) and magnetic resonance imaging (MRI) performance with oropharyngeal non-Hodgkin's lymphoma (ONHL).Materials and Methods: The complete image data of 30 ONHL cases were analyzed, all patients were performed PET / CT and MRI examination before the treatment, with the time interval of these two inspections not exceeding 14 days. The distribution, morphology, MRI signal characteristics, enhancement feature, standardized uptake value (SUV) max value and lymph node metastasis way of the lesions were analyzed. Results: Among the 30 cases, 23 cases were derived from the B-cell (76.7%), 5 cases were derived from the peripheral T cells (16.7%) and 2 cases were derived from the NK/T cells (6.7%). 19 cases exhibited the palatine tonsil involvement (63.3%). As for the lesion appearance, 10 cases appeared as mass, 8 cases were the diffused type and 12 cases were the mixed type. 25 cases exhibited the SUVmax value of PET / CT primary lesions as 11 or more (83.3%). MRI showed that all patients exhibited various degrees of parapharyngeal side-compressed narrowing, but MRI still exhibited the high-signal fat, and the oropharyngeal mucosa was intact. 25 cases were associated with the neck lymph node metastasis, among who 22 cases had no necrosis in the metastatic lymph nodes, while the rest 3 cases exhibited the central necrosis in the metastatic lymph nodes. Conclusions: PET / CT and MRI have important value in diagnosing and determining the lesion extent of ONHL.

Increased impact of heat domes on 2021-like heat extremes in North America under global warming

Xing Zhang,Tianjun Zhou,Wenxia Zhang,Liwen Ren,Jie Jiang,Shuai Hu,Meng Zuo,Lixia Zhang,Wenmin Man 한국기상학회 2023 한국기상학회 학술대회 논문집 Vol.2023 No.4

A New Public Key Encryption Scheme based on Layered Cellular Automata

( Xing Zhang ),( Rongxing Lu ),( Hong Zhang ),( Chungen Xu ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.10

Cellular automata (CA) based cryptosystem has been studied for almost three decades, yet most of previously reported researches focus on the symmetric key encryption schemes. Up to now, few CA based public key encryption scheme has been proposed. To fill the gap, in this paper, we propose a new public key encryption scheme based on layered cellular automata (LCA). Specifically, in the proposed scheme, based on the T-shaped neighborhood structure, we combine four one-dimensional reversible CAs (set as the private key) to form the transition rules of a two-dimension CA, where the two-dimension CA is set as the corresponding public key. Based on the hardness assumption of the Decisional Dependent CA problem in LCA, we formally prove the proposed scheme is indistinguishably secure against the chosen-plaintext attack (IND-CPA). In addition, we also use a numeric example to demonstrate its feasibility. Finally, analysis of key space and time efficiency are also carried out along with RSA-1024, and the simulation results demonstrate that our proposed scheme is more efficient.

Reverse Iterative Image Encryption Scheme Using 8-layer Cellular Automata

( Xing Zhang ),( Hong Zhang ),( Chungen Xu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7

Considering that the layered cellular automata (LCA) are naturally fit for representing image data in various applications, a novel reverse iterative image encryption scheme based on LCA is proposed. Specifically, the plain image is set as the final configuration of an 8-layer CA, and some sequences derived from a random sequence are set as the pre-final configuration, which ensure that the same plain image will never be encrypted in the same way when encrypted many times. Then, this LCA is backward evolved by following some reversible two order rules, which are generated with the aid of a newly defined T-shaped neighborhood. The cipher image is obtained from the recovered initial configuration. Several analyses and experimental results show that the proposed scheme possesses a high security level and executive performance.

Anomalous magnetization jumps in granular Pb superconducting films

Zhang An-Lei,Jiang Wan-Yan,Chen Xing-Hong,Zhang Xiao-Ke,Lu Wen-Lai,Chen Fei,Feng Zhen-Jie,Cao Shi-Xun,Zhang Jin-Cang,Ge Jun-Yi 한국물리학회 2022 Current Applied Physics Vol.35 No.-

In granular superconductors, the grain boundaries are closely related to the vortex dynamics and the macroscopic superconducting properties. In our research, Pb films with different grain sizes were prepared by tuning the substrate temperature. With the grain size decreasing, Pb films are prone to feature the anomalous magnetization jumps in the M − T curves, while in the M − H curves flux avalanche happens. Both phenomena appear in the same region of the H − T phase diagram and thus are considered to have the same origin. The further theoretical analysis shows that with grain size decreasing the pinning mechanism evolves from a mixed δTc and δl pinning to the δl pinning mechanism. The results shed light on the study of pinning mechanism for granular superconductors and is beneficial to the potential application of manipulating vortex pinning by regulation of intrinsic defects.

Extraction of density-of-states in amorphous InGaZnO thin-film transistors from temperature stress studies

Xing-Wei Ding,Jianhua Zhang,Weimin Shi,Hao Zhang,Chuanxin Huang,Jun Li,Xueyin Jiang,Zhilin Zhang 한국물리학회 2014 Current Applied Physics Vol.14 No.12

The instability of amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) with different active layer thicknesses under temperature stress has been investigated through using the density-of-states (DOS). Interestingly, the a-IGZO TFT with 22 nm active layer thickness showed a better stability than the others, which was observed from the decrease of interfacial and semiconductor bulk trap densities. The DOS was calculated based on the experimentally-obtained activation energy (EA), which can explain the experimental observations. We developed the high-performance Al2O3 TFT with 22 nm IGZO channel layer (a high mobility of 7.4 cm2/V, a small threshold voltage of 2.8 V, a high Ion/Ioff 1.8 107, and a small SS of 0.16 V/dec), which can be used as driving devices in the next-generation flat panel displays.

Energy Efficient Hybrid Satellite Terrestrial 5G Networks with Software Defined Features

Jiaxin Zhang,Xing Zhang,Muhammad Ali Imran,Barry G. Evans,Yan Zhang,Wenbo Wang 한국통신학회 2017 Journal of communications and networks Vol.19 No.2

In order to improve the manageability and adaptabilityof future 5G wireless networks, the software orchestration mechanism,named software defined networking (SDN) with controland user plane (C/U-plane) decoupling, has become one of themost promising key techniques. Based on these features, the hybridsatellite terrestrial network is expected to support flexibleand customized resource scheduling for both massive machinetype-communication (MTC) and high-quality multimedia requestswhile achieving broader global coverage, larger capacity and lowerpower consumption. In this paper, an end-to-end hybrid satelliteterrestrial network is proposed and the performance metrics, e. g., coverage probability, spectral and energy efficiency (SE andEE), are analysed in both sparse networks and ultra-dense networks. The fundamental relationship between SE and EE is investigated,considering the overhead costs, fronthaul of the gateway(GW), density of small cells (SCs) and multiple quality-ofservice(QoS) requirements. Numerical results show that comparedwith current LTE networks, the hybrid system with C/U split canachieve approximately 40% and 80% EE improvement in sparseand ultra-dense networks respectively, and greatly enhance thecoverage. Various resource management schemes, bandwidth allocationmethods, and on-off approaches are compared, and theapplications of the satellite in future 5G networks with softwaredefined features are proposed.

Expression of FMD Virus-like particles in yeast Hansenula polymorpha and immunogenicity of combine with CpG and Alumimun adjuvant

Jianhui Zhang,Jun Ge,Juyin Li,Jianqiang Li,Yong Zhang,Yinghui Shi,Jiaojiao Sun,Qiongjin Wang,Xiaobo Zhang,Xing-xu Zhao 대한수의학회 2023 Journal of Veterinary Science Vol.24 No.1

Background: Inactivated vaccines are limited in preventing foot-and-mouth disease (FMD) due to safety problems. Recombinant virus-like particles (VLPs) are an excellent candidate for a novel vaccine for preventing FMD, given that VLPs have similar immunogenicity as natural viruses and are replication- and infection-incompetent. Objectives: The 3C protease and P1 polyprotein of type O FMD virus (FDMV) was expressed in yeast Hansenula polymorpha to generate self-resembling VLPs, and the potential of recombinant VLPs as an FMD vaccine was evaluated. Methods: BALB/c mice were immunized with recombinant purified VLPs using CpG oligodeoxynucleotide and aluminum hydroxide gel as an adjuvant. Cytokines and lymphocytes from serum and spleen were analyzed by enzyme-linked immunosorbent assay, enzyme-linked immunospot assay, and flow cytometry. Results: The VLPs of FMD were purified successfully from yeast protein with a diameter of approximately 25 nm. The immunization of mice showed that animals produced high levels of FMDV antibodies and a higher level of antibodies for a longer time. In addition, higher levels of interferon-γ and CD4+ T cells were observed in mice immunized with VLPs. Conclusions: The expression of VLPs of FMD in H. polymorpha provides a novel strategy for the generation of the FMDV vaccine.

Spatial Analysis of Rural Medical Facilities Using Huff Model : A Case Study of Lankao County, Henan Province

Pengyan Zhang,,Xing Ren,Qianqian Zhang,Jianjian He,Yongmin Chen 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.1

Rural health care reformed in the new situation in China, indicating that the construction of medical facilities not only to solve difficult medical problems, but also to take into account the efficiency and fairness of the use of medical resources allocation. Facing these problems, the paper aims to assess the spatial distribution of rural medical services by using geographic information systems (GIS) and spatial accessibility indexes. Lankao County in Henan Province and 21 hospitals of township and county are selected as study samples. First adopted ArcGIS10.0 to collate data. Second, the authors established a network dataset to analysis the maximum coverage for hospital services space accessibility. At last, established Huff model and built a scientific evaluation for the current hospitals’ distribution. There are several findings from the case study. First, the distribution of medical facility is unbalanced in rural areas in term of per capita, such as opportunity for assessing medical services and the convenience of utilizing medical services. Second, by using the Huff Model to calculate the potential population in service regions, the Huff Model to calculate the potential population in service regions, the results showed the low efficiency of the use of medical resources and the problems in these regions.