Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice

Wu, Y.-L.,Jiang, Y.-Z.,Jin, X.-J.,Lian, L.-H.,Piao, J.-Y.,Wan, Y.,Jin, H.-R.,Joon Lee, J.,Nan, J.-X. G. Fischer 2010 Phytomedicine Vol.17 No.6

The protective effect of a diterpenoid acanthoic acid (AA) isolated from Acanthopanax koreanum Nakai was investigated in acetaminophen (APAP)-induced hepatic toxicity. Drug-induced hepatotoxicity induced by an intraperitoneal (i.p.) injection of 300mg/kg (sub-lethal dose) of APAP. Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily). Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1α (HIF-1α) expression in liver tissue. Our results indicated that AA protected liver tissue from the oxidative stress elicites by APAP-induced liver damage and suggestes that the hepatic protection mechanism of AA would relate to antioxidation and hypoxia factor on APAP-induced hepatotoxicity.

NON-NATURAL EQUILIBRIUM CONTOUR DESIGN FOR RADIAL TIRE AND ITS INFLUENCE ON TIRE PERFORMANCE

J. YANG,G. L. WANG,Z. J. WAN,C. LIANG,H. C. ZHOU 한국자동차공학회 2016 International journal of automotive technology Vol.17 No.4

Two types of radial tire 11.00R20 and 385/65R22.5 are chosen as the research objects, and their carcass contours are redesigned by using Sakai Hideo’s, Frank’s and the new non-natural equilibrium contour design theories, which were based on analyzing the current non-equilibrium contour design theories of radial tire. Then the tire wear, rolling resistance and grip performance of the two radial tires designed by different non-natural equilibrium contour design theories are comprehensively analyzed with the finite element software ABAQUS. The results show that Frank’s contour design theory can reduce tire wear; the new non-natural equilibrium contour design theory can enhance tire wear, rolling resistance performance, etc. It is also found that the tire carcass contour has great influence on tire performance, especially on the tire rolling resistance. The new non-natural equilibrium contour theory provides a guidance to reduce the tire rolling resistance, and it can break through the target conflicts in tire performance. The tire with the new non-natural equilibrium carcass contour can enhance its comprehensive performance.

Effect of Age on Energy Requirement for Maintenance and Growth of Dorper and Hu Crossbred F1 Ewes Weighing 20 to 50 kg

H.T. Nie,Y.J. Wan,J.H. You,Z.Y. Wang,S. Lan,Y.X. Fan,F. Wang 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.8

This research aimed to define the energy requirement of Dorper and Hu Hybrid F1 ewes 20 to 50 kg of body weight, furthermore to study energy requirement changes with age and evaluate the effect of age on energy requirement parameters. In comparative slaughter trial, thirty animals were divided into three dry matter intake treatments (ad libitum, n = 18; low restricted, n = 6; high restricted, n = 6), and were all slaughtered as baseline, intermediate, and final slaughter groups, to calculate body chemical components and energy retained. In digestibility trial, twelve ewes were housed in individual metabolic cages and randomly assigned to three feeding treatments in accordance with the design of a comparative slaughter trial, to evaluate dietary energetic values at different feed intake levels. The combined data indicated that, with increasing age, the net energy requirement for maintenance (NEm) decreased from 260.62±13.21 to 250.61±11.79 kJ/kg0.75 of shrunk body weight (SBW)/d, and metabolizable energy requirement for maintenance (MEm) decreased from 401.99±20.31 to 371.23±17.47 kJ/kg0.75 of SBW/d. Partial efficiency of ME utilization for maintenance (km, 0.65 vs 0.68) and growth (kg, 0.42 vs 0.41) did not differ (p>0.05) due to age; At the similar condition of average daily gain, net energy requirements for growth (NEg) and metabolizable energy requirements for growth (MEg) for ewes during late fattening period were 23% and 25% greater than corresponding values of ewes during early fattening period. In conclusion, the effect of age upon energy requirement parameters in the present study were similar in tendency with previous recommendations, values of energy requirement for growth (NEg and MEg) for Dorper and Hu crossbred female lambs ranged between the NRC (2007) recommendation for early and later maturating growing sheep.

Effect of Age on Energy Requirement for Maintenance and Growth of Dorper and Hu Crossbred F1 Ewes Weighing 20 to 50 kg

Nie, H.T.,Wan, Y.J.,You, J.H.,Wang, Z.Y.,Lan, S.,Fan, Y.X.,Wang, F. Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.8

This research aimed to define the energy requirement of Dorper and Hu Hybrid $F_1$ ewes 20 to 50 kg of body weight, furthermore to study energy requirement changes with age and evaluate the effect of age on energy requirement parameters. In comparative slaughter trial, thirty animals were divided into three dry matter intake treatments (ad libitum, n = 18; low restricted, n = 6; high restricted, n = 6), and were all slaughtered as baseline, intermediate, and final slaughter groups, to calculate body chemical components and energy retained. In digestibility trial, twelve ewes were housed in individual metabolic cages and randomly assigned to three feeding treatments in accordance with the design of a comparative slaughter trial, to evaluate dietary energetic values at different feed intake levels. The combined data indicated that, with increasing age, the net energy requirement for maintenance ($NE_m$) decreased from $260.62{\pm}13.21$ to $250.61{\pm}11.79kJ/kg^{0.75}$ of shrunk body weight (SBW)/d, and metabolizable energy requirement for maintenance (MEm) decreased from $401.99{\pm}20.31$ to $371.23{\pm}17.47kJ/kg^{0.75}$ of SBW/d. Partial efficiency of ME utilization for maintenance ($k_m$, 0.65 vs 0.68) and growth ($k_g$, 0.42 vs 0.41) did not differ (p>0.05) due to age; At the similar condition of average daily gain, net energy requirements for growth ($NE_g$) and metabolizable energy requirements for growth ($ME_g$) for ewes during late fattening period were 23% and 25% greater than corresponding values of ewes during early fattening period. In conclusion, the effect of age upon energy requirement parameters in the present study were similar in tendency with previous recommendations, values of energy requirement for growth ($NE_g$ and $ME_g$) for Dorper and Hu crossbred female lambs ranged between the NRC (2007) recommendation for early and later maturating growing sheep.

Optical Nanostructures Fabricated by SU-8 based Nanoimprint Lithography

R. Liu,B.-R. Lu,S.-Q. Xie,J. Wan,Z. Shu,X.-P. Qu,Y. Chen 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3

The high resolution low-cost and high-volume nano-pattering capability of the nanoimprint lithography (NIL) and the high optical transmittance of SU-8 in the infrared, the visible and the near-UV light ranges have enabled us to apply the SU-8 based NIL to produce various optical nanostructures. We fabricated dielectric and metallic gratings of various groove density (1000 – 5000 lines/mm) in a relatively large area (10 mm × 10 mm) and planar chiral photonic meta-material structure in SU-8 with periods of both 600 nm and 4 μm. We also designed and successfully fabricated distributed Bragg reflectors (DBRs) with Si/SiO2/SU8/air structures Optical measurements of the SU-8 based nanostructures showed good optical performance and interesting properties, and the experimental data agree reasonably well with simulation results. The high resolution low-cost and high-volume nano-pattering capability of the nanoimprint lithography (NIL) and the high optical transmittance of SU-8 in the infrared, the visible and the near-UV light ranges have enabled us to apply the SU-8 based NIL to produce various optical nanostructures. We fabricated dielectric and metallic gratings of various groove density (1000 – 5000 lines/mm) in a relatively large area (10 mm × 10 mm) and planar chiral photonic meta-material structure in SU-8 with periods of both 600 nm and 4 μm. We also designed and successfully fabricated distributed Bragg reflectors (DBRs) with Si/SiO2/SU8/air structures Optical measurements of the SU-8 based nanostructures showed good optical performance and interesting properties, and the experimental data agree reasonably well with simulation results.

Four-dimensional calibration turntable of the motional Stark effect diagnostic on EAST

Huang, X.,Liu, D. M.,Liu, C.,Fu, J.,Wan, B. N.,Lyu, B.,Wu, Z. W.,Holcomb, C. T.,Ko, J.,Rowan, W. L.,Huang, H.,Miao, G. Z. American Institute of Physics 2018 Review of scientific instruments Vol.89 No.10