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- 저자 : Yunyun Fan (검색결과 2 건)
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Research on the Entrainment of Path Material by the Granular Flow
Yunyun Fan,Fengyuan Wu,Ming Li,Li Liang 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.12
The experiment and numerical simulation were used to study the entrainment of path material by the granular flow. The effects of several factors on the entrainment were observed through the experiment. Research results show that when the granular flow passes on the loose material, the entrainment and deposition occur simultaneously. The final mass reduction in the entrainment area is a comprehensive performance of the entrainment and deposition. In general, the mass reduction in the entrainment area is directly proportional to the relative position of the source area and inversely proportional to the length of the entrainment area. The longer the entrainment area, the stronger the retarding effect on the granular flow. Within the ability of the entrainment area to support grains, the deposition mass increases as the mass of the material from the source area increases. The numerical results show that the entrainment mainly passes through three main stages. In the first stage, the shear friction and collision between grains form a limited entrainment. In the second stage, the granular flow mainly scales up the entrainment by scraping. In the last stage, the rear part of the granular flow is deposited in the formed pit due to resistance.
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Ruilian Xiu,Jie Jia,Qing Zhang,Fengjiao Liu,Yaxin Jia,Yuanyuan Zhang,Beibei Song,Xiaodan Liu,Jingwei Chen,Dongyang Huang,Fan Zhang,Juanjuan Ma,Honglin Li,Xuan Zhang,Yunyun Geng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6
Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration- dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 μM, 19.7 ± 0.4 μM, and 24.5 ± 2.1 μM, while the maximal effect (Emax) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.
ScienceON
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