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신영석(Yung Seok Shin) 한국강구조학회 1993 韓國鋼構造學會誌 Vol.5 No.2
An efficient and easy-to-implement procedure for the globally convergent homotopy method for nonlinear optimization is discussed in this paper. An envelope function is used to augment multiple inequality constraints so that difficult active set strategy can be avoided. The procedure is applied for a simple constrained minimization problem, and its convergency is tested for different values of an envelope function parameter. The results indicates that for a large value of the parameter, fast convergence is achieved, but it could result in large errors in the solution. The paper also demonstrates application to optimal design of one-ring stiffened shells. A sequence of optimal designs has been obtained as a function of external hydrostatic pressure. It is seen from the results that the single ring-stiffener works more effectively at lower levels of pressure.
녹차부산물을 이용한 기능성 축산물 증명에 대한 분자생물학적 접근
강신석 ( Shin Seok Kang ),현공율 ( Gong Yul Hyun ),최해연 ( Hae Yeun Choi ),조우영 ( Woo Young Cho ),김태융 ( Tae Yung Kim ),강신권 ( Shin Kwon Kang ),강정부 ( Chung Boo Kang ) 한국가축위생학회 2005 韓國家畜衛生學會誌 Vol.28 No.2
Green tea was known which regulated adipocyte differentiation metabolism. The mecha nism on the lipid decreased contents of TAG in the plasma. In addition, green tea increased the expression leptin mRNA, PPAR δ mRNA and TGF β. The tea tested was korean powdered green tea. In this experiment, Sprague-Dawley(SD) rats were fed 3 % green tea(powdered) for 3 weeks on the basal diet and obese diet and green tea grouts-fed pork meats, duck meats. The expression of leptin mRNA and PPAR δ mRNA were up-regulated in the green tea-fed groups compared with those of the not green tea-fed groups. There were no significantly difference on the expression of leptin mRNA and PPAR δ mRNA in green tea grouts-fed pork meats, duck meats as compared with the not fed green tea grouts meats. TGF β mRNA, TNF α mRNA and adipsin mRNA were not expressed in the pork meats, duck meats. The expression of TGF β mRNA, TNF α mRNA and adipsin mRNA were observed in the experimental rats but no significantly difference on the contents. Physiologic regulated genes were not expressed in the green tea grout-fed pork meats and duck meats.
Development of 3D Terrain Visualization for Navigation Simulation using a Unity 3D Development Tool
Shin, Il-Sik,Beirami, Mohammadamin,Cho, Seok-Je,Yu, Yung-Ho The Korean Society of Marine Engineering 2015 한국마린엔지니어링학회지 Vol.39 No.5
3D visualization of navigation simulation is to visualize the environment conditions (e.g. nearby ships, dynamic characteristics, environment, terrain, etc) for any users on ships at sea. Realistic 3D visualization enables the users to be immersed to it and guarantees the reliability of the simulation. In particular, terrain visualization contains many virtual objects, so it is time and cost-intensive for object modelling. This paper proposes a 3D terrain visualization method that can be realized in a short time and with low cost by using the Unity 3D development tool. The 3D terrain visualization system requires bathymetric and elevation terrains, and Aids to Navigations (AtoNs) to be realized. It also needs to include 3D visualization objects including bridges, buildings and port facilities for more accurate simulation. Bathymetric and AtoN elements are acquired from ENC, and the elevation element is acquired from SRTM v4.1 digital elevation chart database developed by NASA. Then, the bathymetric and elevation terrains are generated, and the satellite images are superposed by using this terrain information. The longitudinal and latitudinal information of the AtoNs are converted to the 3-axis information to position the AtoN locations. The 3D objects such as bridges, buildings and port facilities are generated and the terrain visualization is completed. The proposed method realizes more realistic 3D terrain visualization of Busan Port.
Induction of Apoptosis and Inhibition of Invasion in Human Hepatoma Cells by Anthocyanins from Meoru
Shin, Dong Yeok,Ryu, Chung Ho,Lee, Won Sup,Kim, Dong Chul,Kim, Seok Hyun,Hah, Young-Sool,Lee, Sung Joong,Shin, Sung Chul,Kang, Ho Sung,Choi, Yung Hyun Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1171 No.1
<P>Anthocyanins belong to a class of flavonoids exhibiting antioxidant and anti-inflammatory actions as well as a variety of chemotherapeutic effects. However, little is known about the cellular and molecular mechanism of anticancer activity. In this study, we investigated if the anthocyanins (delphinidin-3,5-diglucoside: cyanidin-3,5-diglucoside: petunidin-3,5-diglucoside: delphinidin-3-glucoside: malvdin-3,5-diglucoside: peonidin-3,5-diglucoside: cyanidin-3-glucoside: petunidin-3-glucoside: peonidin-3- glucoside: malvidin-3- glucoside = 27: 63: 8.27: 1:2.21: 6.7: 1.25: 5.72: 1.25) isolated from meoru (Vitis coignetiae Pulliat) exerted antiproliferative and anti-invasive and apoptotic effects on human hepatoma Hep3B cells. It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). The anthocyanins also significantly inhibited the migration and invasion of Hep3B cells through a matrigel-coated chamber. Taken together this study indicates that the anthocyanins from meoru have antiproliferative and anti-invasive effects and may induce apoptosis through the activation of the mitochondrial pathway and inhibition of antiapoptotic proteins. This study provides evidence that the anthocyanins isolated from meoru might be useful in the treatment of human hepatitis B-associated hepatoma.</P>
임실군 보건의료원의 갱년기장애 극복 프로그램에 참여한 갱년기장애 여성의 치료 결과 분석
김석희 ( Seok-hee Kim ),김서희 ( Seo-hee Kim ),김영주 ( Yung-ju Kim ),김정옥 ( Jung-ok Kim ),박미선 ( Mi-sun Park ),안효연 ( Hyo-yeon An ),조다혜 ( Da-hye Jo ),강인숙 ( In-suk Kang ),신경이 ( Kyung-i Shin ),이송이 ( Song-i Lee ),김 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.30 No.3
Objectives: This study has been conducted on public health purposes for people with Menopausal disorders in rural areas. Methods: From February, 2017 to June, 2017, we performed the Korean Medicine in the “Menopausal Disorder Overcoming Program" conducted by the department of Health service, Imsil-Gun bogun Hospital. Menopausal women who participated were treated with acupuncture, moxibustion, Jaeumganghwa-tang for 20 weeks. Of the 34 patients, 16 patients were excluded due to absence of treatment at least once. And 18 treatment outcomes were analyzed. Results: The KI results showed that the average score decreased in 7 out of 11 questions after treatment. The results of BDI, the mean scores of the 17 questions except the 4 questions of the 21 questions after the treatment decreased. 12, 16, and BDI total score were statistically significantly reduced before and after treatment. Conclusions: The results of the Korean Medicine treatment seemed to be effective in alleviating facial flushing, insomnia, depressive symptoms and other symptoms in menopausal disorders.
( Jeong Seok Kim ),( Dok Hyun Yoon ),( In Keun Park ),( Shin Kim ),( Jung Sun Park ),( Sang Wook Lee ),( Joor Yung Huh ),( Chan Sik Park ),( Cheol Won Suh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Primary testicular diffuse large B-cell lymphoma (DLBCL) is a kind of rare but aggressive extranodal lymphoma. Relapse in central nervous system (CNS) is majorconcerns in the treatment of primary testicular DLBCL. However, the role of intrathecal prophylaxis is still controversial issue. Methods: We retrospectively reviewed the medical records of 14 patients with primary testicular DLBCL diagnosed between November 2000 and June 2012. We analyzed CNS relapse rate in the patients treated without intrathecal prophylaxis. Survival curves were estimated using the Kaplan-Meier method. Results: The median age at diagnosis was 57 years (range, 41-79 years). Unilateral testicular involvement was observed in 13 patients. Nine (64. 3%) patients were in stage I, 1 in stage II, and 4 in stage IV. The international prognostic index was low or low-intermediate risk in 12 patients, and high-intermediate risk in 2 patients. Thirteen patients underwent orchiectomy. All of the patients received systemic chemotherapy without intrathecal prophylaxis. And, prophylactic radiotherapy was administered to the contralateral testis in 12 patients. The median follow-up period of surviving patients was 39 months (10-139 months). Median overall survival had not been reached and median progression-free survival was 3. 8 years. Four patients experienced relapse, but CNS relapse was observed in only one patient (7. 1%) with stage IV disease at 27 months after a complete response. Conclusions: Even without intrathecal prophylaxis, the rate of relapse in the CNS appears not to be high in Korean patients with primary testicular DLBCL compared with prior reports.