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Is Disintegration Occurring in the European Union: Empirics and Viewpoints of Integration Theories
( Yun-chen Lai ) 한국EU학회 2019 Asia-Pacific Journal of EU Studies Vol.17 No.2
The European Union (EU) has been a pioneer in regional integration and long been its most developed model. However, the recent increase in populism raises questions about the integration of the EU. Some pessimists even predict that disintegration of the EU might occur if populism becomes stronger. It is difficult to deny that the EU has faced a series of major setbacks in the last decade. However, setbacks do not equal disintegration. This thesis starts from recent disintegration phenomena in Europe and discusses the underlying reasons for those problems. Furthermore, this thesis attempts to utilize theoretical perspectives to elucidate recent trends. Mainstream integration theories will be discussed and reviewed. Transactionalism of Karl Deutsch will be used to observed whether the EU is really suffering from disintegration. Furthermore, Post-Functionalism will help to explain why certain factor, i.e., identity, matter than other indicators to explain the integration and disintegration of the EU.
A GFP-labeled Human Colon Cancer Metastasis Model Featuring Surgical Orthotopic Implantation
Chen, Hong-Jin,Yang, Bo-Lin,Chen, Yu-Gen,Lin, Qiu,Zhang, Shu-Peng,Gu, Yun-Fei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Colorectal cancer has become a major disease threatening human health. To establish animal models that exhibit the characteristics of human colorectal cancer will not only help to study the mechanisms underlying the genesis and development effectively, but also provide ideal carriers for the screening of medicines and examining their therapeutic effects. In this study, we established a stable, colon cancer nude mouse model highly expressing green fluorescent protein (GFP) for spontaneous metastasis after surgical orthotopic implantation (SOI). GFP-labeled colon cancer models for metastasis after SOI were successfully established in all of 15 nude mice and there were no surgery-related complications or deaths. In week 3, primary tumors expressing GFP were observed in all model animals under fluoroscopy and two metastatic tumors were monitored by fluorescent imaging at the same time. The tumor volumes progressively increased with time. Seven out of 15 tumor transplanted mice died and the major causes of death were intestinal obstruction and cachexia resulting from malignant tumor growth. Eight model animals survived at the end of the experiment, 6 of which had metastases (6 cases to mesenteric lymph nodes, 4 hepatic, 2 pancreatic and 1 mediastinal lymph node). Our results indicate that our GFP-labeled colon cancer orthotopic transplantation model is useful with a high success rate; the transplanted tumors exhibit similar biological properties to human colorectal cancer, and can be used for real-time, in vivo, non-invasive and dynamic observation and analysis of the growth and metastasis of tumor cells.
Yun-Chen Lai,Chin-Peng Chu 연세대학교 미래사회통합연구센터 2019 Journal of Conflict and Integration Vol.3 No.2
The EU has faced serious crises recently. EU integration has resulted in greater public attention and made cooperation more controversial. This contribution explores three questions: why crises occur under (current) EU governance; how a crisis of EU governance will result in a crisis of EU integration; and how the EU could solve its problems. Issues both inside and outside of the EU borders are discussed to investigate the questions above. It is argued that an imbalanced governance structure and a democratic deficit cause risks of disintegration and stagnation. Multi-level governance should be revisited to augment participation of public sectors, to respond to the current politicization trend, and to relieve the democratic deficit problem.
Yun Chen,Yaqi Li 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.9
This paper studies the stability analysis problem for time-varying delay systems. An appropriate Lyapunov-Krasovskii functional (LKF) is constructed where its derivative is a quadratic polynomial function of the delay. A novel negative condition of the mentioned quadratic function with two variable parameters is developed to ensure that the LKF derivative is negative, reducing conservatism on some similar results. Besides, an extended version of Bessel-Legendre inequality is introduced to be employed in the stability analysis of time-varying delay systems. Then, some stability criteria with less conservatism are derived for two kinds of the time-varying delay. Finally, the effectiveness of the proposed stability criteria is demonstrated through three examples.
Nitric Oxide Synthase 3 Gene Variants and Colorectal Cancer: a Meta-Analysis
Chen, Yang,Li, Jie,Guo, Yun,Guo, Xiao-Yun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: Colorectal cancer (CRC) is the worldwide disease which causes enormous losses every year. Recent studies suggested that environmental and gene factors might be the etiologies in increasing the risk of morbidity. Nitric oxide synthase 3 (NOS3) gene polymorphisms are said to be associated with CRC risk but the conclusion is still controversial. Materials and Methods: Pubmed and HuGENet databases up to December 2013 were used in this meta-analysis. Three different certain genotypic models were applied, namely dominant (AA+AC versus CC), recessive (AA versus AC+CC), per-allele analysis (A vs C). In addition, information on tumor sites and pathologic stages was collected. The strength of associations was assessed through combining odds ratio (OR) and 95% confidence interval (CI). Results: Finally, five and three studies about the rs1799983 and rs2070744 were covered in the analysis with 2,745 cases and 2,478 controls. Three models were applied, but no significant association was found for NOS3 G894T/rs1799983 (dominant: OR=0.999, 95%CI=0.797-1.253, $I^2$=63.8%; recessive: OR=0.924, 95%CI=0.589-1.450, $I^2$=59.3%; allele analysis: OR=0.979, 95%CI=0.788-1.216, $I^2$=74.9%) and T-786C/rs2070744 (dominant: OR=1.138, 95%CI=0.846-1.530, $I^2$=67.9%; recessive: OR=0.956, 95%CI=0.708-1.291, $I^2$=0.0%; allele analysis: OR=1.110, 95%CI=0.865-1.425, $I^2$=69.4%). The same results were also obtained for tumor sites and pathologic stage subgroups. After further analyzing the NOS3 gene, rs1799983 as the tag- and functional SNP was presented. Conclusions: On the basis of this meta-analysis and the characteristics of the NOS3 gene, we suggested rs1799983 might be a key locus associated with CRC risk. Further prospective studies were needed to make more comprehensive explanation of the associations.