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Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array
Yumnam, Silvia,Saralamma, Venu Venkatarame Gowda,Raha, Suchismita,Lee, Ho Jeong,Lee, Won Sup,Kim, Eun Hee,Lee, Sang Joon,Heo, Jeong Doo,Kim, Gon Sup SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol. No.
<P>Protein array technology not only identifies a large number of proteins but also determines their expression levels. In the present study, antibody array analysis is used to decipher the proteins involved in hesperidin-induced cell death in HepG2 cells. Altered proteins in hesperidin treated cells were compared with that of untreated control cells by using a RayBio<SUP>®</SUP> Label-based (L series) human antibody array kit. The identified proteins were further confirmed using western blot analysis. STRING software based analysis was used to determine the protein-protein interactions. Many proteins related to signal transduction, cellular mechanisms, cell growth and proliferation regulatory proteins were identified. Among the proteins identified Hsp90, Smac/DIABLO, Prdx6 and FRK were significantly reduced in hesperidin treated cells. To the best of the authors' knowledge, the present study is the first to use antibody array for identifying proteins marker in hesperidin-induced cell death in HepG2 cells. The present study provides a novel insight into the anticancer mechanism of hesperidin.</P>
Yumnam, Silvia,Raha, Suchismita,Kim, Seong Min,Saralamma, Venu Venkatarame Gowda,Lee, Ho Jeong,Ha, Sang Eun,Heo, Jeong Doo,Lee, Sang Joon,Kim, Eun Hee,Lee, Won Sup,Kim, Jin A.,Kim, Gon Sup D.A. Spandidos 2018 ONCOLOGY REPORTS Vol.40 No.6
<P>Proteomic analysis serves as an important biological tool for identifying biological events. Novel biomarkers of a specific disease such as cancer may be identified using these promising techniques. The aim of the present study was to investigate the effect of tangeretin and to identify potential biomarkers in AGS gastric cancer cells using a proteomics approach. The results of the present study revealed that tangeretin inhibited AGS cell viability dose-dependently with a half-maximal inhibitory concentration of 100 µM. Two-dimensional gel electrophoresis was performed to determine the potential biomarker between control and tangeretin (100 µM)-treated AGS cells. A total of 16 proteins was identified from 36 significant protein spots using matrix-assisted laser-desorption/ionization time-of-flight-mass spectrometry using peptide fingerprinting. The bioinformatics tools Protein ANalysis THrough Evolutionary Relationships (PANTHER) and Database for Annotation, Visualization and Integrated Discovery (DAVID) were used to identify the functional properties and association of the proteins obtained. Using western blot analysis, the regulatory pattern of four selected proteins, protein kinase Cε, mitogen-activated protein kinase 4, phosphoinositide 4-kinase and poly(ADP-ribose) polymerase 14, were successfully verified in replicate sample sets. These selected proteins are primarily involved in apoptosis signaling, angiogenesis, cell cycle regulation, receptor kinase binding, intracellular cytoplasmic and nuclear alterations. Therefore, aim of the present study was to identify potential diagnostic biomarkers from the functional categories of altered protein expression in tangeretin-inhibited AGS gastric cancer cell viability.</P>
서재옥,Silvia Yumnam,정광원,김선여 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.3
Finasteride is a well-known 5a-reductase inhibitorused for treatment of alopecia and prostate cancer. But theeffect of finasteride in regulating melanogenesis is stillunclear. In the present study the role of finasteride onmelanogenesis was investigated. Finasteride decrease melaninlevel in melanocyte melan-a cells and B16F10 melanomacells without inducing cytotoxicity. MC1R (melanocortin 1receptor) protein expression was also inhibited by finasteridethereby decreasing the expression of adenylate cyclase, MITF(Melanogenesis associated transcription factor), tyrosinases,TRP (tyrosinase-related protein) -1 and -2. Thus our studysuggest that finasteride inhibits melanogenesis in melanocyteand melanoma cells by inhibiting MC1R.
FIXED POINTS OF α_s-β_s-ψ-CONTRACTIVE MAPPINGS IN S-METRIC SPACES
Deep Chand,Yumnam Rohen 경남대학교 수학교육과 2023 Nonlinear Functional Analysis and Applications Vol.28 No.2
In this paper, we have developed the idea of α-β-ψ-contractive mapping in S-metric space and renamed it α_s-β_s-ψ-contractive mapping. We have proved some results of fixed point present in literature in partially ordered S-metric space using α_s-β_s-admissible and α_s-β_s-ψ-contractive mapping.
SOME RATIONAL F-CONTRACTIONS IN b-METRIC SPACES AND FIXED POINTS
Thounaojam Stephen,Yumnam Rohen,M. Kuber Singh,Konthoujam Sangita Devi 경남대학교 수학교육과 2022 Nonlinear Functional Analysis and Applications Vol.27 No.2
In this paper, we introduce the notion of a new generalized type of rational F-contraction mapping. Further, the concept is used to obtain fixed points in a complete b-metric space. We also prove another unique fixed point theorem in the context of b-metric space. Our results are verified with example.
Kang, Min Cheol,Yumnam, Silvia,Kim, Sun Yeou MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.11
<P>Collagen peptide (CP) has beneficial effects on functions of the skin, such as skin barrier function and skin elasticity, in vivo. However, there are few studies investigating the mechanism underlying the potential effects of CP in skin epidermal moisturization after ultraviolet B (UVB) irradiation. In this study, we examined whether orally-administered CP affects the loss of skin hydration induced by UVB irradiation in hairless mice. SKH-1 hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB. The potential effects of CP were evaluated by measuring the transepidermal water loss (TEWL), skin hydration, wrinkle formation, and hyaluronic acid expression in the dorsal mice skin. We found that oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group. Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue. The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group. In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP. In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging. Therefore, we suggest that CP can be used as a nutricosmetic ingredient with potential effects on UVB-induced skin dehydration and moisture loss in addition to wrinkle formation.</P>