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Dopamine-dependent social information processing in non-human primates
Lee, Young-A,Lionnet, Sarah,Kato, Akemi,Goto, Yukiori Springer Berlin Heidelberg 2018 Psychophamacology Vol.235 No.4
<P><B>Rationale</B></P><P>Dopamine (DA) is a neurotransmitter whose roles have been suggested in various aspects of brain functions. Recent studies in rodents have reported its roles in social function. However, how DA is involved in social information processing in primates has largely remained unclear.</P><P><B>Objectives</B></P><P>We investigated prefrontal cortical (PFC) activities associated with social vs. nonsocial visual stimulus processing.</P><P><B>Methods</B></P><P>Near-infrared spectroscopy (NIRS) was applied to Japanese macaques, along with pharmacological manipulations of DA transmission, while they were gazing at social and nonsocial visual stimuli.</P><P><B>Results</B></P><P>Oxygenated (oxy-Hb) and deoxygenated (deoxy-Hb) hemoglobin changes as well as functional connectivity based on such Hb changes within the PFC network which were distinct between social and nonsocial stimuli were observed. Administration of both D1 and D2 receptor antagonists affected the Hb changes associated with social stimuli, whereas D1, but not D2, receptor antagonist affected the Hb changes associated with nonsocial stimuli.</P><P><B>Conclusions</B></P><P>These results suggest that mesocortical DA transmission in the PFC plays significant roles in social information processing, which involves both D1 and D2 receptor activation, in nonhuman primates. However, D1 and D2 receptor signaling in the PFC mediates different aspects of social vs. nonsocial information processing.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1007/s00213-018-4831-x) contains supplementary material, which is available to authorized users.</P>
The Roles of Dopamine D1 Receptor on the Social Hierarchy of Rodents and Nonhuman Primates
Yamaguchi, Yoshie,Lee, Young-A,Kato, Akemi,Goto, Yukiori Oxford University Press 2017 International Journal of Neuropsychopharmacology Vol.20 No.4
<P><B>Abstract</B></P><P><B>Background:</B></P><P>Although dopamine has been suggested to play a role in mediating social behaviors of individual animals, it is not clear whether such dopamine signaling contributes to attributes of social groups such as social hierarchy.</P><P><B>Methods:</B></P><P>In this study, the effects of the pharmacological manipulation of dopamine D1 receptor function on the social hierarchy and behavior of group-housed mice and macaques were investigated using a battery of behavioral tests.</P><P><B>Results:</B></P><P>D1 receptor blockade facilitated social dominance in mice at the middle, but not high or low, social rank in the groups without altering social preference among mates. In contrast, the administration of a D1 receptor antagonist in a macaque did not affect social dominance of the drug-treated animal; however, relative social dominance relationships between the drug-treated and nontreated subjects were altered indirectly through alterations of social affiliative relationships within the social group.</P><P><B>Conclusions:</B></P><P>These results suggest that dopamine D1 receptor signaling may be involved in social hierarchy and social relationships within a group, which may differ between rodents and primates.</P>
Dopamine-dependent visual attention preference to social stimuli in nonhuman primates
Yamaguchi, Yoshie,Atsumi, Takeshi,Poirot, Romain,Lee, Young-A,Kato, Akemi,Goto, Yukiori Springer Berlin Heidelberg 2017 Psychophamacology Vol.234 No.7
<P><B>Rationale</B></P><P>Dopamine (DA) plays a central role in reward processing. Accumulating evidence suggests that social interaction and social stimuli have rewarding properties that activate the DA reward circuits. However, few studies have attempted to investigate how DA is involved in the processing of social stimuli.</P><P><B>Objectives</B></P><P>In this study, we investigated the effects of pharmacological manipulations of DA D1 and D2 receptors on social vs. nonsocial visual attention preference in macaques.</P><P><B>Methods</B></P><P>Japanese macaques were subjected to behavioral tests in which visual attention toward social (monkey faces with and without affective expressions) and nonsocial stimuli was examined, with D1 and D2 antagonist administration.</P><P><B>Results</B></P><P>The macaques exhibited significantly longer durations of gazing toward the images with social cues than did those with nonsocial cues. Both D1 and D2 antagonist administration decreased duration of gazing toward the social images with and without affective valences. In addition, although D1 antagonist administration increased the duration of gazing toward the nonsocial images, D2 antagonism had no effect.</P><P><B>Conclusions</B></P><P>These results suggest that both D1 and D2 receptors may have roles in the processing of social signals but through separate mechanisms.</P>