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Wang Yi,Peng Yuehan,Yang Yuefei,Hu Yuemin,Wang Hao,Xu Lei,Ju Huiming 한국유전학회 2022 Genes & Genomics Vol.44 No.12
Background: Perilipin 1 (PLIN1) is a lipid droplet scaffolding protein that plays a regulatory role in fat decomposition and mitochondrial function. Objective: In this study, the effects of PLIN1 gene knockout (PLIN1-KO) and PLIN1 gene overexpression (PLIN1-EX) on cell metabolism and mitochondrial function in porcine skeletal muscle satellite cells were assessed. Methods: Porcine skeletal muscle satellite cells were used as the control group (NC). The expression of mitochondrial function-related proteins was detected by western blot. Apoptosis, cell cycle, mitochondrial function-related indices, mitochondrial structure, and morphology were measured by flow cytometry. Results: Our results demonstrated that stable expression of the PLIN1 gene in skeletal muscle satellite cells is critical to maintaining cell metabolism and mitochondrial function. After knockout and overexpression of the PLIN1 gene, the anti-apoptotic ability of cells was enhanced, and the metabolic activity of the cells was accelerated, but at the cost of mitochondrial structural damage, reduction in the number of mitochondria, and decreased mitochondrial function. Conclusion: This study explored the effect of the PLIN1 gene on the mitochondria and metabolism of porcine skeletal muscle satellite cells and provided a theoretical basis for the subsequent study of the effects of PLIN1 on muscle tissue development and meat quality.
Jianguang Yue,Hua Fang,Yuefei Xia,Hongquan Wang,Kai Wu 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.6
The damage evolutions of square concrete-fi lled steel tubular (CFT) columns were experimentally studied by the axial compression cyclic loading test and the acoustic emission (AE) monitoring technique. Based on the mechanical analysis and damage observations, the limit damage states, i.e. inner concrete cracking, confi nement of steel tube, yielding and buckling of steel tube, weld seam splitting and inner concrete spalling were verifi ed. The released strain energy due to the damage of CFT column was monitored by the AE technique and analyzed by the peak frequency classifi cation method. The results show that the buckling of steel tube is the damage state with the maximum load carrying capacity for CFT columns. Most of the released strain energy were detected by the AE signals with the peak frequency between 30 and 75 kHZ and most of the strain energy were released after the buckling of the steel tube.
Scavenging Effects of Tea Catechins on Superoxide and Hydroxy Radical
Park Jaeil,Liuji Chen,Xianqiang Yang,Shengrong Shen,Yuefei Wang,Ryu Beung Ho 한국생명과학회 2002 Journal of Life Science Vol.12 No.2
Tea catechins, the most important compounds in tea polyphenols, can efficiently scavenge superoxide anion free-radical (O₂-·), hydroxyl radical. (·OH) The mechanism of scavenging active oxygen free radicals was investigated by ESR spin trapping technique and Chemiluminescence. Results showed that various tea catechins constitute an antioxidant cycle in accordance with the decreasing order of the first reductive potential, and produce the effect of cooperative strength each other. Esterificated catechins could scavenge active oxygen free radicals more effectively than the non-esterificated ones. When ·OH and O₂-·- were scavenged by (-)-epigallocatechin gallate [(-)- EGCG], the stoichiometric factors were 6, and the rate constants of scavenging reaction reached 7.71x10(6) and 3.52x10(11) L mmol-¹ S-¹, respectively. In the mean time, tea catechins could scavenge superoxide anion fiee radical (O₂-·) and hydroxyl radical (·OH) in a dose dependent manner. But at higher concentration or pH value, tea catechins can induce the prooxidant.
Mi Xie,Liying Gao,Zhiming Liu,RuiYing Yuan,Dongzhi Zhuoma,Dikye Tsering,Yuefei Wang,Shan Huang,Bin Li 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.12
Diabetic patients are more prone to developing nonalcoholic fatty liver disease (NAFLD) compared with healthy people. As a plant homologous to both medicine and food, Malus toringoides (Rehd.) Hughes has been used as an intervention for both NAFLD and diabetes. However, the effect and mechanism of M. toringoides on NAFLD on type 2 diabetes mellitus (T2DM) is unclear. The current investigation was designed to evaluate the ameliorative effects and mechanism of M. toringoides ethanol extract (CBTM-E375) on T2DM, and to identify the compounds in these extracts. The effects of CBTM-E375 on T2DM were verified using a high-fat diet-/streptozotocin-induced diabetic rat and free fatty acid (0.5 mM)-induced human hepatocellular carcinoma cell (HepG2) models. The components of CBTM-E375 were identified by high performance liquid chromatography-mass spectrometry/mass spectrometry. Our results demonstrate that CBTM-E375 ameliorated lipid accumulation (total cholesterol, triglyceride), oxidative stress (superoxide dismutase, catalase, malondialdehyde, glutathione peroxidase), and inflammation (tumor necrosis factor-α [TNF-α], interleukin [IL]-1β, IL-6, C-reactive protein [CRP]) in vivo and in vitro, these effects were associated with a CBTM-E375-mediated downregulation of SREBP-1c (sterol regulatory element binding protein 1c) and the NF-κB (nuclear factor κB) signaling pathway. A total of 20 chemical compounds were identified in CBTM-E375, including phlorizin, isoquercitrin, chlorogenic acid, quercetin, naringenin, and trigonelline, which have been reported to have positive effects on diabetes or on NAFLD.