An Analysis of Regenerative Braking and Energy Saving for Electric Vehicle with In-Wheel Motors

Li-qiang Jin,Pemg-fei Chen,Yue Liu 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12

Based on the structural features of electric vehicle (EV) driven by in-wheel motors and the characteristics of low speed as well as high torque for in-wheel motors, regenerative braking method for in-wheel motors has been presented. All braking torque for vehicle deceleration is output by in-wheel motors under Medium-intensity braking condition for the sake of recovering the maximum braking energy. The vehicle dynamics model that includes the hydraulic braking system and in-wheel motors driving system has been built by AMESim software. Simulation has been carried out for vehicle driving conditions by NEDC cycle and FTP75 cycle. The result shows that the recovery rate of braking energy is increased dramatically by in-wheel motor braking method. The energy efficiency of electric vehicle has been improved more than 30%. It is significant for electric vehicles to increase driving range and reduce costs.

Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p

Yong-Ping Chen,Feng-Bin Lu,Da-Zhi Chen,Lu Chen,En-De Hu,Jin-Lu Wu,Hui Li,Yue-Wen Gong,Zhuo Lin,Xiao-Dong Wang,Ji Li,Xiao-Ya Jin,Lan-Man Xu 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.12

MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-223-3p to treat autoimmune hepatitis in an experimental model. We found that MSC-exosomes were successfully incorporated with miR-223-3p and delivered miR-223-3p into macrophages. Moreover, there was no toxic effect of exosomes on the macrophages. Furthermore, treatments of either exosomes or exosomes with miR-223-3p successfully attenuated inflammatory responses in the liver of autoimmune hepatitis and inflammatory cytokine release in both the liver and macrophages. The mechanism may be related to the regulation of miR-223-3p level and STAT3 expression in the liver and macrophages. These results suggest that MSC-exosomes can be used to deliver miR-223-3p for the treatment of autoimmune hepatitis.

Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p

Lu, Feng-Bin,Chen, Da-Zhi,Chen, Lu,Hu, En-De,Wu, Jin-Lu,Li, Hui,Gong, Yue-Wen,Lin, Zhuo,Wang, Xiao-Dong,Li, Ji,Jin, Xiao-Ya,Xu, Lan-Man,Chen, Yong-Ping Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.12

MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-223-3p to treat autoimmune hepatitis in an experimental model. We found that MSC-exosomes were successfully incorporated with miR-223-3p and delivered miR-223-3p into macrophages. Moreover, there was no toxic effect of exosomes on the macrophages. Furthermore, treatments of either exosomes or exosomes with miR-223-3p successfully attenuated inflammatory responses in the liver of autoimmune hepatitis and inflammatory cytokine release in both the liver and macrophages. The mechanism may be related to the regulation of miR-223-3p level and STAT3 expression in the liver and macrophages. These results suggest that MSC-exosomes can be used to deliver miR-223-3p for the treatment of autoimmune hepatitis.

Experimental research and molecular dynamics simulation on thermal properties of capric acid/ethylene-vinyl/graphene composite phase change materials

Yue Gu,Linhua Jiang,Weizhun Jin,Zhenhua Wei,Xing Liu,Mingzhi Guo,Kailun Xia,Lei Chen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-

In this paper, a new series of phase change materials (PCMs) composed of capric acid/ethylene-vinylacetate/graphene (CA/EVA/GR) were prepared and thermal properties were investigated using moleculardynamics simulation. The composite PCMs were characterized by Fourier transform infraredspectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanningcalorimetry (DSC) and thermal conductivity measurement. FT-IR, XRD and SEM results manifest that CAcan be successfully wrapped by EVA and GR additives, and there is no chemical reaction between CA, EVAand GR. DSC results indicate that adding GR into CA/EVA can result in composite PCMs maintain the highlatent heat, while too much GR will cause a significant reduction in latent heat. Thermal conductivityobtained from experimental tests reveal that GR can gradually enhance the thermal conductivity of CA/EVA with increasing dosage of GR. The experimental results of thermal conductivity fall close to that ofmolecular dynamics (MD) simulation at GR dosages below 1.8 wt%, but the experimental results present atrend which is contrary to MD simulation at higher GR dosages. The mean square displacement (MSD)results manifest that composite PCMs containing 1.8 wt% GR has the highest diffusion coefficient, whilehigher GR dosage will reduce the diffusion coefficient gradually.

A Relay-assisted Secure Handover Mechanism for High-speed Trains

( Yue Zhao ),( Bo Tian ),( Zhouguo Chen ),( Jin Yang ),( Saifei Li ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.2

Considering that the existing Long Term Evolution is not suitable for the fast and frequent handovers of high-speed trains, this paper proposes a relay-assisted handover mechanism to solve the problems of long handover authentication time and vulnerable to security attacks. It can achieve mutual authentication for train-ground wireless communication, and data transmission is consistent with one-time pad at the same time. The security analysis, efficiency analysis and simulation results show that the proposed mechanism not only realizes the forward security and resists many common attacks, but also effectively reduces the computational overhead of train antenna during the secure handover process. When the running speed of a train is lower than 500km/h, the handover delay is generally lower than 50ms and the handover outage probability is less than 1.8%. When the running speed of a train is 350km/h, the throughput is higher than 16.4mbps in the process of handover. Therefore, the secure handover mechanism can improve the handover performance of high-speed trains.

Clinical Study of Thalidomide Combined with Dexamethasone for the Treatment of Elderly Patients with Newly Diagnosed Multiple Myeloma

Chen, Hai-Fei,Li, Zheng-Yang,Tang, Jie-Qing,Shen, Hong-Shi,Cui, Qing-Ya,Ren, Yong-Ya,Qin, Long-Mei,Jin, Ling-Juan,Zhu, Jing-Jing,Wang, Jing,Ding, Jie,Wang, Ke-Yuan,Yu, Zi-Qiang,Wang, Zhao-Yue,Wu, Tian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: To investigate the relationship between the efficacy and safety of different doses of thalidomide (Thal) plus dexamethasone (Dex) as the initial therapy in elderly patients with newly diagnosed multiple myeloma (MM). Methods: Clinical data of 28 elderly patients with newly diagnosed MM who underwent the TD regimen as the initial therapy were analyzed retrospectively. The patients were divided into two groups according to the maximal sustained dose of Thal: lower dose (group A) and higher dose (group B). The overall response rate (ORR), progression free survival (PFS), overall survival (OS), and adverse events (AES) were compared between the two groups. Results: A total of 28 patients were followed up with a median of 18 months. The ORR was 60.1%. The median response time and PFS were 2.0 and 17.0 months, respectively. The mean sustained dose of Thal in group B was significantly higher than group A (292.9 mg v 180.4 mg, P=0.01). There was no significantly difference in ORR (57.1% v 64.3%, P=1.00) and PFS (9.63months v 17.66 months, P=0.73) between groups A and B. During the follow up, only five patients died (<40%) and, therefore, median OS values were not available. It is estimated, however, that the mean survival time in the two groups was 35.6 and 33.4 months (P>0.05), respectively. All of the patients tolerated the treatment well. The incidence of AES in patients with a grading above 3 in group B was significantly higher than in group A (P=0.033). Conclusions: The TD regimen results in a high response rate and manageable AES as the initial therapy in elderly patients with MM. TD should be considered as the front line regimen for the treatment of elderly patients with MM in areas with financial constraints. The clinical response can be achieved at a low dose Thal with minimal toxicity.

Lipopolysaccharide induces oxidative stress and inhibits osteogenic differentiation in periodontal ligament stem cells through downregulating Nrf2

Chen Yue,Gulinuer Awuti,Zhao Jin 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2

Background Periodontitis, a common inflammatory disease in adults, causes the loss of alveolar bone, eventually leading to tooth loss. The inhibition of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) might be involved in the development of alveolar bone loss. Objective The aim of the present study was to investigate the regulatory roles of nuclear factor erythroid-2-related factor 2 (Nrf2) during the osteogenic differentiation of PDLSCs in the presence of LPS. Results In the present study, LPS reduced cell viability, inhibited osteogenic differentiation, and caused oxidative stress in PDLSCs. Antioxidants, glutathione (GSH), N-acetyl-L-cysteine (NAC), and ascorbic acid (AA), had rescue effects. Furthermore, LPS reduced antioxidant capability and expression of Nrf2 and its down-stream antioxidant genes. Nrf2 overexpression abolished the cytotoxic effects of LPS by alleviating ROS level. Conclusion LPS induced oxidative stress through downregulating Nrf2-mediated antioxidant pathways, and inhibited osteogenic differentiation in PDLSCs. Strategies enhancing antioxidant capability could reverse the impaired osteogenic potential caused by LPS.

The Relatedness Between Graphene Oxide Lateral Size and the Mechanical Properties of Calcium Alginate Composite Fibers

Lijun Jin,Yiqi Wu,Xinjun Hu,Qinjia Chen,Yue Lu,Yongxiao Bai 한국섬유공학회 2023 Fibers and polymers Vol.24 No.2

It is widely recognized that combining alginate with graphene oxide (GO) is an effective method in improving the propertiesof alginate fiber. However, how the lateral size of GO influences the properties of the composite fiber is still unclear. Inthis work, GO was separated into four kinds of different lateral sizes with the assistance of centrifugation and high-powerultrasound. The tensile strength of calcium alginate/graphene oxide (CaAlg/GO) composite fiber increased with the lateralsize of GO. Surprisingly, the combination of large and small GO performed the superior reinforcement effect. The tensilestrength and Young’s modulus increased from 407.66 MPa and 13.87 GPa to 556.97 MPa and 20.57 GPa, respectively. Inaddition, the water absorption ability of CaAlg/GO composite fiber reduced with the decreasing of the lateral size of GO. With significantly improved mechanical properties and fine biocompatibility, the CaAlg/GO composite fibers may havepotential applications in the biotechnological, biomedical, and tissue engineering areas.

A Survey on Phase Change Memory-Aware Cache Management

Kaimeng Chen,Peiquan Jin,Lihua Yue 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.1

PCM (phase change memory) has been regarded as one of the most promising NVRAM. Due to its excellent features including high access speed, good scalability, byte addressability, and low idle power, PCM is expected to be an alternative to DRAM or flash memory in the future. So far, many different kinds of architecture have been proposed to merge PCM into the memory hierarchy of computer systems. For PCM-based computer systems, considering that PCM has various properties differing with DRAM and conventional storage media, traditional cache management policies based on DRAM and disks have to be re-designed. In this paper, we present a survey on the cache management policies for PCM-based systems that employ PCM as main memory or as secondary storage. Specially, for different PCM-based architectures, we explain how PCM-aware cache management policies exploit PCM’s advantages and overcome PCM’s drawbacks like asymmetric read/write latencies.

Electronic Structures and Optical Properties of CuSCN with Cu Vacancies

Wei Jin,Guo-Qing Yue,Fu-Shun Ke,Song Wu,Hai-Bin Zhao,Liang-Yao Chen,Song-You Wang,Yu Jia 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.8

Based on density functional theory (DFT) within the generalized gradient approximation (GGA) using the CASTEP code, we calculated the formation energy of a Cu vacancy, as well as the band structure and the optical properties of β-CuSCN with Cu vacancies. Removal a Cu atom from the 32-site and the 72-site supercell results in an enlargement of the band-gap and a slight relaxation in the lattice parameter. An accepter level above the valence band maximum is observed in the 32-site supercell with a Cu vacancy, which results in the onset of a small absorption pre-peak at 0.65 eV.