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Effects of Pulsed Electro-Magnetic Fields on Dry Eye Syndrome
Subin Park,Hyunseon Yu,Donghwan Ko,Sangmin Shim,Byungjo Jung 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
Pulsed Electro-Magnetic Fields (PEMF) is known as a technology used in clinical trials for the purpose of pain control and treatment due to its non-invasive, safe, and convenient use. PEMF has been found to affect physiological processes such as increased cell activity, depolarization of cell membranes and changes in membrane potential, improvement of inflammation, and improvement of blood flow, but the specific mechanism is not clearly defined. Pulsed electromagnetic fields (PEMFs) are emerging as innovative therapies for the control of inflammation that can significantly affect tissue regeneration. Dry eye syndrome is a disorder of the tear film caused by insufficient or excessive evaporation of tears, which causes damage to the ocular surface between the eyelids and is associated with symptoms of ocular discomfort. The causes of dry eye syndrome are diverse, including aging, chronic conjunctivitis, decreased female hormones, and environmental factors. Among them, we focused on dry eye syndrome caused by chronic conjunctivitis. When cells that function as mucous glands in the conjunctiva decrease due to chronic inflammation, mucus secretion decreases. As a result, water cannot be held in the mucus layer, and the aqueous layer of the tear layer flows out through the tear duct into the nose. In this study, we tried to observe the improvement effect of dry eye syndrome through stimulation of PEMF. This study was conducted with an approval from the Institutional Review Board at the Mirae campus of the Yonsei University (Protocol 1041849-202101-BM-019-03). Experiment was conducted on 9 subjects with dry eye syndrome in their 20s. The subjects had previously been diagnosed with dry eye syndrome or had been diagnosed with conjunctivitis or the like. It was observed continuously for 5 days, and PEMF (20Hz, 7mT) equipment was worn under the eyelids for 30 minutes every day. Dry eye examination was performed at the hospital on the 1st and 5th days. There are two tests for dry eye syndrome, Break-Up Time test and Schirmer test. Schirmer Test (ST) measures the amount of tears secreted in 5 minutes by hanging a piece of paper of a certain length on the lower eyelid. Break-Up Time (BUT) test measures the time it takes for the tear film to break through an ophthalmic microscope and fluorescein. Subjective evaluation of subjects through a survey was also carried out. 〈그림 본문참조〉 In the survey, it showed a decrease of 31.008% from 14.333 points to 9.898 points on average, and 7 out of 9 people showed a subjective improvement effect. In ST, 4 out of 9 patients showed an increase in tear volume in the left and right eyes. In BUT test, 3 out of 9 subjects increased the BUT value 5 days after PEMF stimulation. It was confirmed that all three people with improved BUT showed an improvement effect in the survey and ST. The results of this study may be of limited improvement in subjects with chronic conjunctivitis. It seems that long-term monitoring for improvement of dry eye syndrome is necessary, and additional research on this is also required.
Woo Yu Ri,Moon Ji Hwan,Shin Ha Yeon,Bang Yoon Ji,Song Seowon,Lee Subin,Lee Dong Hun,Kim Hyun Je,Kim Jung Eun 대한의학회 2024 Journal of Korean medical science Vol.39 No.31
Background: Atopic dermatitis (AD) is a chronic inflammatory cutaneous disorder, that emerges from intricate interplays among genetic predisposition, immune dysregulation, environmental factors, and compromised skin barrier. Understanding the inflammatory pathway in AD is important due to its fundamental role in the pathogenesis of AD. This study aimed to explore the diverse spectrum of proteins linked to the inflammation of AD and the relationship between systemic biomarkers and clinical severity in AD. Methods: We examined the blood samples from 48 patients with AD and 48 healthy controls (HCs) using the Proximity Extension Assay (Olink). Differentially expressed proteins (DEPs) were identified and Pearson correlation analysis was conducted to determine systemic proteomic biomarkers associated with severity of AD. Results: A total of 29 DEPs were significantly up-regulated and 2 DEPs were significantly down-regulated in AD compared with the HC. The MCP-4, IL-18, MCP-3, TNFRSF9, and IL17C were the top 5 highest DEPs associated with the severity of AD. Conclusion: Our study sheds light on the intricate network of inflammatory proteins in AD and their potential implications for disease severity. Our results indicate that these systemic inflammatory proteins could be valuable for assessing AD severity and enhancing our understanding of the disease's complexity and its potential management strategies.