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인터넷 중독 청소년의 자존감, 우울, 충동성과 사회관계
윤혜미(Hye Mee Yoon),남영옥(Young Ok Nam) 충북대학교 생활과학연구소 2009 생활과학연구논총 Vol.13 No.1
Over the last decade, there has been increased interest in the addictive potential of the Internet, and past studies have indicated that the addictive pattern of Internet use are associated with some psycho-social traits of the users and adolescents and young adults are especially vulnerable population. This study investigated the extent to which psycho-social factors were related to the extent of Internet usage among adolescents and to examine the potential influences of self-esteem, depression and impulsiveness on social relations of the adolescents with Internet addiction. A total of 2,495 adolescents ages between 15-17 responded to the questionnaire, which included Young's IAT, Rosenberg's Self-esteem instrument, Beck's BDI, BISII, Hudson's IFR and IPR. Results showed that 61.0% of the sample were considered Internet addicted(4.0% seriously pathological, 57.0% moderate), who suffer from higher level of depression, impulsiveness, and problems of social relations and low self-esteem than their peers. Regression analysis indicated that problems in social relations among adolescents with Internet addiction were predicted by low self-esteem and depression. No link was found between impulsiveness and social relations. Results suggest that preventive efforts for Internet addiction of adolescents are in imminent needs. Implications to help professionals are addressed.
Enhanced exchange bias and thermal stability of magnetic tunnel junctions with Ta blocking layer
Young Deung Kim,Jin Pyo Hong,Chae Ok Kim,Ja Hyun Koo,Kap Soo Yoon,Ki Woong Kim 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.3
An antiferromagnetic/ferromagnetic (AFM/FM) structure with an ultra-thin Ta blocking layer was investigated in order to improve thermal stability after an annealing process. Measurements by X-ray photoelectron spectroscopy directly conrm the interdiusion mechanism of Mn atoms of IrMn in exchange-biased structure with increasing annealing temperature. Experimental results show that Mn atoms in NiFe/IrMn structure lead to faster thermal diusion than those in CoFe/IrMn structure. The diusion of Mn atoms induces anomalous reduction of exchange bias strength. Finally, the insertion of an ultra-thin Ta layer between FM and AFM structure as antidi usion barrier eectively protects the expected Mn diusion for annealing temperatures up to 800 C, resulting in enhancement of thermal stability.
Antiobesity Effect of Baek-Kimchi (Whitish Baechu Kimchl) in Rats Fed High Fat Diet
Yoon, Ji-Young,Jung, Keun-Ok,Kim, So-Hee,Park, Kun-Young The Korean Society of Food Science and Nutrition 2004 Preventive Nutrition and Food Science Vol.9 No.3
Baek-kimchi (whitish baechu kimchi) was evaluated for anti-obesity properties and effects on triglyceride (TG) and cholesterol in blood and adipose tissues in rats fed a high fat (20 %) diet, and compared to the similar effects of baechu kimchi. Baek-kimchi does not use red pepper powder but contains higher levels of sliced radish and pear than baechu kimchi. SD rats were raised for four weeks on either a normal diet (ND, based on the AIN-93M diet), high fat diet (HFD, supplemented with 16% lard oil in the ND), or HFD containing 5 % baek-kimchi or 5 % baechu kimchi. Feed consumption was not different among the groups, but weight gains were significantly lower in the groups fed either the normal diet or HFD with baek-kimchi or baechu kimchi diets than the group fed HFD alone. The weights of liver and epididymal and perirenal fat pads in baek-kimchi and baechu kimchi diet groups were lower than those of the HFD groups, but the baek-kimchi diet group had lower epididymal and perirenal fat pad weights than the baechu kimchi diet group (p<0.05). The baechu kimchi dietary group also had significantly lower triglyceride and cholesterol contents in liver and epididymal and perirenal fat, reversing the higher levels seen in HFD. Baek-kimchi and baechu kimchi diets were also effective in lowering serum triglyceride and cholesterol levels (p<0.05). These results suggest that baek-kimchi and baechu kimchi consumption can reverse the effects of HFD on weight gain and blood and tissue lipids, and that baek-kimchi is more effective than baechu kimchi. The greater effect is probably due to the higher content of radish and pear used in baek-kimchi.
Yoon, Jung-Hoon,Lee, Jung-Kee,Kim, Young-Ok,Oh, Tae-Kwang Microbiology Society 2005 International journal of systematic and evolutiona Vol.55 No.1
<P>A Gram-negative, motile, non-spore-forming, pleomorphic and lipolytic bacterial strain, M37<SUP>T</SUP>, was isolated from an intertidal sediment of the Yellow Sea in Korea. This organism grew optimally at 25-28 °C and in the presence of 1-2 % NaCl. It did not grow without NaCl or in the presence of more than 6 % NaCl. Strain M37<SUP>T</SUP> was characterized chemotaxonomically by having Q-8 as the predominant respiratory lipoquinone and C16 : 1<I>ω</I>7<I>c</I> and/or iso-C15 : 0 2-OH and C16 : 0 as the major fatty acids. The DNA G+C content was 47 mol%. Phylogenetic analyses based on 16S rRNA gene sequences placed strain M37<SUP>T</SUP> within the clade comprising <I>Photobacterium</I> species, forming a coherent cluster with the type strains of <I>Photobacterium profundum</I> and <I>Photobacterium indicum</I> (16S rRNA gene similarity levels of 97·5-98·0 %). The mean DNA-DNA relatedness levels between strain M37<SUP>T</SUP> and <I>P. profundum</I> JCM 10084<SUP>T</SUP> and <I>P. indicum</I> DSM 5151<SUP>T</SUP> were in the range 12-15 %. Similarities between 16S rRNA gene sequences of strain M37<SUP>T</SUP> and those of the type strains of the other <I>Photobacterium</I> species ranged from 93·9 % (with <I>Photobacterium fischeri</I>) to 96·2 % (with <I>Photobacterium phosphoreum</I>). On the basis of phenotypic properties and phylogenetic and genomic distinctiveness, strain M37<SUP>T</SUP> (=KCTC 10562BP<SUP>T</SUP>=DSM 16190<SUP>T</SUP>) should be placed in the genus <I>Photobacterium</I> as a novel species, for which the name <I>Photobacterium lipolyticum</I> sp. nov. is proposed.</P>
Yoon, Il,Seo, Joobeom,Lee, Ji-Eun,Song, Mi Ryoung,Lee, So Young,Choi, Kyu Seong,Jung, Ok-Sang,Park, Ki-Min,Lee, Shim Sung Royal Society of Chemistry 2005 Dalton Transactions Vol.2005 No.14
<P>By virtue of simple one donor variations of O<SUB>2</SUB>S<SUB>2</SUB>X-donor macrocycles (L<SUP>1</SUP>: X&z.dbd;S, L<SUP>2</SUP>: X&z.dbd;O and L<SUP>3</SUP>: X&z.dbd;NH) towards silver(<SMALL>I</SMALL>) perchlorates, four supramolecular complexes (1–3) with different topologies have been isolated; L<SUP>1</SUP> afforded solvent- and anion-free sandwich complex (1), otherwise L<SUP>2</SUP> and L<SUP>3</SUP> gave the dimeric (2a), 1-D polymeric (2b), and tetrameric bowl-type (3) complexes with solvent or anion coordination.</P> <P>Graphic Abstract</P><P>By virtue of simple one donor variations of O<SUB>2</SUB>S<SUB>2</SUB>X-donor macrocycles (L<SUP>1</SUP>: X&z.dbd;S, L<SUP>2</SUP>: X&z.dbd;O and L<SUP>3</SUP>: X&z.dbd;NH) towards silver(<SMALL>I</SMALL>) perchlorates, four supramolecular complexes (1–3) with different topologies have been isolated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b506438d'> </P>
Purification and Characterization of Aspartase from Hafnia alvei
Yoon,Moon-Young,Choi,Kyong-Jae,Kim,Joung-Mok,Park,Jae-Ho,Park,Jun-Bum,Kim,Yeon-Ok,Kyung,Jin-Burm The Korea Science and Technology Center 1998 BMB Reports Vol.31 No.4
Aspartase (EC 4.3.1.1.) from Hafnia alvei was purified to homogeneity by a combination of DEAE-cellulose, Red A-agarose, and Sepharose 6B chromatography. The purified enzyme appeared homogeneous on denatured SDS-polyacrylamide gel electrophoresis. The purified enzyme was a tetrameric protein composed of identical subunits with a molecular weight of 55,000 daltons. The optimum pH for the enzymatic reaction was 8.5 and the optimum temperature for maximum activity was 45℃. The enzyme has an absolute requirement of divalent metal ions (Mg²+, Mn²+) at the alkaline pH. The enzyme, however, was inactivated in the presence of other divalent cations such as Zn²+, Ca²+. The helical content of the purified enzyme was estimated by CD spectropolarimetry to be 61%.
Flavobacterium sasangense sp. nov., isolated from a wastewater stream polluted with heavy metals.
Yoon, Hwan Sik,Aslam, Zubair,Song, Geun Cheol,Won Kim, Seon,Jeon, Che Ok,Chon, Tae Soo,Chung, Young Ryun Society for General Microbiology 2010 International journal of systematic and evolutiona Vol.60 No.1
( Yoon Ok Jang ),( Soon Koo Baik ),( Mee-yon Cho ),( Kyu-sang Park ),( Seung-kuy Cha ),( Sung Hoon Kim ),( Moon Young Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: The beneficial effects of simvastatin on fibrosis in various organs have been reported. In addition, bone marrow-derived mesenchymal stem cells (MSCs) have been suggested as an effective therapy for hepatic fibrosis and cirrhosis. Recent evidence suggests that pharmacological treatment devoted to regulating stem cell function is a potential new therapeutic strategy, which is drawing nearer to clinical practice. The aim of this study was to determine whether the combination treatment of simvastatin plus MSCs (Sim-MSCs) could have a synergistic effect on hepatic fibrosis in a thioacetamide (TAA)-induced cirrhotic rat model. Methods: Hepatic fibrosis was induced in Sprague-Dawley rats by intraperitoneal injection of TAA (300 mg/kg body weight) twice a week for 12 weeks. Animals were randomly allocated into four groups (each group, n = 10) as follows: group I (G1, sham group); group II (G2, untreated cirrhotic group), which received the TAA injections; group III (G3, Simvastatin treated group), which received both the TAA injections and the simvastatin treatment; and group IV (G4, Simvastatin plus MSCs treated group), which received both the TAA injections and the Sim-MSCs treatment. G3 and G4 were given simvastatin at 10 mg·kg-1·day-1 via drinking water for 5 weeks. The BM-MSCs were injected directly into the right lobe of the liver at 6 and 8 weeks during the 12-week course of TAA administration. After 12 weeks, the effect of simvastatin and BM-MSCs on hepatic fibrosis was analyzed histomorphologically using the Laennec fibrosis scoring system, and the collagen proportionate area was quantified. Cirrhosis-related factors, such as transforming growth factor β1 (TGF-β 1), type 1 collagen (collagen-1), α-smooth muscle actin (α-SMA), and P-Smad3/Smad3 expression levels, were evaluated using real-time polymerase chain reaction and western blot assays. Results: Cirrhotic livers from rats treated with Sim-MSCs exhibited histological improvement compared to those treated with simvastatin alone. Sim-MSCs combination treatment reduced hepatic collagen distribution, lowered the hydroxyproline content, and rescued liver function impairment in rats with TAA-induced cirrhosis. These protective effects were more potent with Sim-MSCs than with simvastatin alone. The upregulation of collagen-1, α-SMA, TGF-β1, and Smad3 phosphorylation in cirrhotic livers was prevented by administration of Sim-MSCs. The Sim-MSCs combination treatment exerted strong protective effects against hepatic fibrosis by suppressing TGF-β/Smad signaling. Conclusions: Simvastatin could act synergistically with MSCs as an efficient therapeutic approach for intractable cirrhosis.