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Choi, Yi-Rac,Chae, Su Young,Ahn, Cheol-Hee,Lee, Minhyung,Oh, Seungjoon,Byun, Youngro,Rhee, Byoung Doo,Ko, Kyung Soo Informa Healthcare 2007 Journal of drug targeting Vol.15 No.6
<P> Block copolymers consisting of poly(ethylene glycol) (PEG) and poly(amino acid)-based random copolymers were successfully synthesized by the ring opening polymerization of the N-carboxy anhydrides (NCA) of l-lysine and l-phenylalanine. The synthesized copolymers had a molecular weight of around 30,000 and contained l-lysine and l-phenylalanine residues with molar ratios of 10/0, 9/1, 8/2, 7/3 and 6/4. The complex formation of the copolymer and pCMV-luc plasmid DNA was confirmed by the gel retardation assay and zeta potential measurement. Complete neutralization was achieved at an N/P ratio of more than 1.0 and the size of the complex was determined to be around 150 nm by dynamic light scattering. The cytotoxicity and transfection efficiency were tested on the HEK 293T cell line. The synthesized copolymers displayed negligible cytotoxicity, resulting in a cell viability of more than 95%, while those of the poly(l-lysine) (PLL) and poly(ethylenimine) (PEI) homopolymer were around 65 and 55%, respectively, under comparable conditions. The introduction of the hydrophilic PEG is believed to reduce the toxicity of the copolymer, due to its enhanced biocompatibility, and to impart improved stability to the complex under physiological conditions. The transfection efficiency at the optimized charge ratio of 7 was dramatically improved as the molar content of the l-phenylalanine residues in the copolymers increased and reached a maximum value at an l-phenylalanine content of 30 mol%. The transfection efficiency of the PEGK7/plasmid DNA complex was around 80 times higher than that of PLL, despite the presence of neutral PEG as a block segment.</P>
Relationship between intraocular pressure and systemic health parameters in the Korean population
Jong Soo Lee,Young Rac Choi,Ji Eun Lee,Hee Young Choi,Sang Hyup Lee,Boo Sup Oum 대한안과학회 2002 Korean Journal of Ophthalmology Vol.16 No.1
This study examined the influence of age, sex, blood pressure, and obesity index on intraocular pressure (IOP), in order to investigate the relationship between the upper limits of the following two conditions in the general Korean population: the “systolic or diastolic hypertensive and obese” group and the “systolic or diastolic hypotensive and lean” group. A total of 6828 healthy subjects (13,656 eyes) underwent automated multi-phasic tests, including tonometry, blood pressure, visual field, and body mass index. The 6,828 subjects were divided into five groups based on age; less than 40, 40 to 49, 50 to 59, 60 to 69, and over 70 years old. They were also divided into four categories on the basis of sex, age, blood pressure, and obesity index. The mean IOP in males (15.8±3.3 mmHg) was significantly higher than in females (14.8±3.1 mmHg) (P < 0.05), but this difference decreased proportionally with increasing age. IOP had a tendency to decrease with increasing age (P < 0.05). IOP increased significantly with increasing systolic blood pressure, diastolic blood pressure and obesity index (all, P < 0.05). The mean IOP of the “systolic or diastolic hypertensive and obese” group was higher than that of the “systolic or diastolic hypotensive and lean” group in the general Korean population (P < 0.05). These data could aid investigation into the epidemiological, etiologic and oriental influences related to the risk factors of glaucoma, especially in oriental populations.