정신분열장애 환자에서의 뇌간청각유발반응

정염성 최신의학사 1987 最新醫學 Vol.30 No.1

전기충격요법에 대한 임상적 고찰

정염성,방승규 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.2

저자들은 1977년 1월 1일부터 1980년 12월 31일까지 카톨릭의과대학 부속 여의도 성모병원 신경정신과 입원환자중 전기충격요법을 받은 272명을 대상으로 임상적 고찰을 하여 다음과 같은 결과를 얻었다. 1. 총 입원환자 1,709명중 272명(15.9%)이 전기충격요법을 받았으며 정신분열증이 75.7%, 주요정동장애가 15.5%, 기타질환이 8.8%이었다. 2. 진단별로 보면 정신분열증의 30.4%, 주요정동장애의 22.5%, 기타질환의 2.8%가 전기충격요법을 받았다. 3. 전기충격요법의 시행횟수는 1인당 평균 8.3회(정신분열증, 8.9회;주요정동장애, 6.3회;기타질환, 7회)이었다. 4. 치료의 대상이 되었던 증상은 정신분열증의 경우 피해망상(20.3%)이 가장 많았으며 주요정동장애의 경우 정신운동성지체 혹은 초조(23.0%)가 가장 많았다. The authors performed this preliminary study to investigate the effect of ECT. The 272 psychiatric inpatients who received ECT atthe Department of Neuropsychiatry of Catholic Medical College from 1977 to 1980 were evaluated for clinical features. The results were as follows; 1. ECT was performed in 15.9% of a total of 1,709 inpatients who were admitted during the study period. Of them, 75.7% were diagnosed as schizophrenia, 15.5% as major affective disorder and 8.8% as others. 2. ECT was performed in 30.4% of the schizophrenics, 22.5% of those with major affective disorder and 2.8% of others. 3. Mean number of ECT was 8.3 times a patient. 4. The most common target symptom was persecutory delusion in schizophrenia and psychomotor retardation or agitation in major affective disorder.

초등 실과 바느질 단원의 모듈 수업이 학업 성취도에 미치는 영향

최염숙 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.2

For this study to determine the effect of modules instruction of sewing in elementary schools, two fifth-grade classes were selected: one as the experimental group receiving modular sewing lessons, and the other as the control group receiving conventional sewing lessons, for a period of four weeks. The cognitive, functional, and definitive aptitudes of each student from both groups wee assessed right before and after the experiment. The result showed that functional and definitive achievements were higher in the experimental group while cognitive achievement did not indicate any significant difference. In conclusion, a modular sewing lesson, coping with difference in individual learning abilities, was found to be a better educational method in functional and definitive areas, but not in cognitive area.

韓國輸出産業高度化에 따른 輸出 增大 方案

崔念淳 건국대학교 1979 樂圓誌 Vol.14 No.1

고 아밀라아제 혈증을 보인 급성 Lithium Carbonate 중독증 1례

홍현상,박흥수,정염성,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2

Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depressive illness. However, lithium cardonate may induce multisystemic adverse effects and toxic effects that, when not recognized, may lead to severe, life-threatening complications. The authors experienced a manic patient who showed severe lithium toxic reactions with hyperamylasemia. The patient was 41-year-old woman who had received lithium carbonate treatment for 3 months. The patient's symptoms and signs of toxic reaction had disappeared after hydration, insulin therapy, and hemodialysis.

Ectopic pregnancy rates in natural versus hormone replacement endometrial preparation in frozen embryo transfer: A meta-analysis

( Hyun Sik Youm ),( Hyun Sik Youm ),( Jong-ryeol Choi ),( Daesik Oh ),( Young Ho Rho ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: To evaluate whether ectopic pregnancy rates differ between natural and hormone replacement endometrial preparation in frozen embryo transfer. 방법: Meta-analysis was performed on the 3 selected studies in the statistical framework R using ‘meta’ package (random effects model: DerSimonian-Laird estimator). The outcome considered in this study was the ectopic pregnancy rates. 결과: The ectopic pregnancy rates were not different between natural and hormone replacement endometrial preparation in frozen embryo transfer (odds ratio [OR] 0.91, 95% confidence interval [CI] 0.40-2.06). 결론: The data presented in this meta-analysis do not support a different risk in ectopic pregnancy between natural and hormone replacement endometrial preparation in frozen embryo transfer.

Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes

Youm, Jae-Boum,Leem, Chae-Hun,Zhang, Yin Hua,Kim, Na-Ri,Han, Jin,Earm, Yung-E. The Korean Society of Pharmacology 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.5

Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied in both the single-channel and the whole-cell level. There is growing evidence to indicate that major stretch-induced changes in electrical activity are mediated by activation of these channels. We aimed to investigate the mechanism of stretch-induced automaticity by exploiting a recent mathematical model of rat atrial myocytes which had been established to reproduce cellular activities such as the action potential, $Ca^{2+}$ transients, and contractile force. The incorporation of SACs into the mathematical model, based on experimental results, successfully reproduced the repetitive firing of spontaneous action potentials by stretch. The induced automaticity was composed of two phases. The early phase was driven by increased background conductance of voltage-gated $Na^+$ channel, whereas the later phase was driven by the reverse-mode operation of $Na^+/Ca^{2+}$ exchange current secondary to the accumulation of $Na^+$ and $Ca^{2+}$ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.

The Effect of Various Factors on Variability of Retinal Nerve Fiber Layer Thickness Measurements Using Optical Coherence Tomography

Youm, Dong Ju,Kim, Hyunjoong,Shim, Seong Hee,Jang, Hyo Ju,Kim, Joon Mo,Park, Ki Ho,Choi, Chul Young,Cho, Jung Gon The Korean Ophthalmological Society 2012 Korean Journal of Ophthalmology Vol.26 No.2

<P><B>Purpose</B></P><P>To evaluate the effects of various factors on the variability of retinal nerve fiber layer (RNFL) thickness measurements using the Stratus optical coherence tomography (OCT) in normal and glaucomatous eyes.</P><P><B>Methods</B></P><P>Four hundred seventy-four subjects (103 normal eyes and 371 glaucomatous eyes) were scanned to determine the RNFL thickness measurements using the Stratus OCT. Measurements were obtained twice during the same day. The standard deviation (SD) was used to compare the variability in RNFL thickness measurements of the normal subjects to that of the glaucomatous patients. Multivariate regression analysis was used to evaluate which covariates were independent predictors of SD in overall mean RNFL thickness.</P><P><B>Results</B></P><P>The mean SD of all RNFL thickness measurements was larger in the glaucoma group except in one sector. In the multivariate regression analysis, the average signal strength (SS) and the relative SS change (difference in SS between initial and repeat scans, divided by initial SS) were independent predictors of the SD in the RNFL thickness measurements (partial R<SUP>2</SUP> = 0.018, 0.013; <I>p</I> = 0.016, 0.040, respectively).</P><P><B>Conclusions</B></P><P>Glaucomatous eyes tend to be more variable than normal eyes in RNFL thickness measurement using the Straus OCT. The average SS and the relative SS changes appear to correlate with the variability in RNFL thickness measurement. Therefore, the results of the RNFL analysis should not be interpreted independently of these factors.</P>

Stretch-activated K^(+) Channels in Rat Atrial Myocytes

Youm, Jae Boum The Korean Physiological Society and The Korean So 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.6

A Computational Model of Cytosolic and Mitochondrial [$Ca^{2+}$] in Paced Rat Ventricular Myocytes

Youm, Jae-Boum,Choi, Seong-Woo,Jang, Chang-Han,Kim, Hyoung-Kyu,Leem, Chae-Hun,Kim, Na-Ri,Han, Jin The Korean Society of Pharmacology 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.4

We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial $Ca^{2+}$ transients and compared the results with those from computer simulation. In rat ventricular myocytes, increasing the rate of stimulation (1~3 Hz) made both the diastolic and systolic [$Ca^{2+}]$ bigger in mitochondria as well as in cytosol. As L-type $Ca^{2+}$ channel has key influence on the amplitude of $Ca^{2+}$ -induced $Ca^{2+}$ release, the relation between stimulus frequency and the amplitude of $Ca^{2+}$ transients was examined under the low density (1/10 of control) of L-type $Ca^{2+}$ channel in model simulation, where the relation was reversed. In experiment, block of $Ca^{2+}$ uniporter on mitochondrial inner membrane significantly reduced the amplitude of mitochondrial $Ca^{2+}$ transients, while it failed to affect the cytosolic $Ca^{2+}$ transients. In computer simulation, the amplitude of cytosolic $Ca^{2+}$ transients was not affected by removal of $Ca^{2+}$ uniporter. The application of carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP) known as a protonophore on mitochondrial membrane to rat ventricular myocytes gradually increased the diastolic [$Ca^{2+}$] in cytosol and eventually abolished the $Ca^{2+}$ transients, which was similarly reproduced in computer simulation. The model study suggests that the relative contribution of L-type $Ca^{2+}$ channel to total transsarcolemmal $Ca^{2+}$ flux could determine whether the cytosolic $Ca^{2+}$ transients become bigger or smaller with higher stimulus frequency. The present study also suggests that cytosolic $Ca^{2+}$ affects mitochondrial $Ca^{2+}$ in a beat-to-beat manner, however, removal of $Ca^{2+}$ influx mechanism into mitochondria does not affect the amplitude of cytosolic $Ca^{2+}$ transients.