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Hee Mang Yang(양희망),Yong Hoon Won(원용훈),Ho Yub Yoon(윤호엽),Chang Hyun Kim(김창현),Yoon Tae Goo(구윤태),In Ho Chang(장인호),Young Wook Choi(최영욱) 한국고분자학회 2020 폴리머 Vol.44 No.6
폴록사머 407(PLX) 하이드로젤은 방광 내 주입을 위한 전달 시스템으로 사용되고 있지만, 젤의 강도가 충분하지 않다는 한계가 있다. 하이드로젤의 점도 및 강도를 조절하기 위해, 다양한 고분자 첨가제를 선별하였다. 점도의 변화는 고분자량 히알루론산(HHA; 33.524 Pa·s) > 히드록시프로필메틸셀룰로스 > 키토산 > 저분자량 HA > 알긴산 > 카보폴(24.332 Pa·s) 순서로 관찰되었다. 고분자 첨가는 PLX 하이드로젤의 열 가역적 특성을 변화시키지 않았으며, 젤화 온도(21.0-25.3 °C) 및 젤화 시간(17.28-28.32초)을 나타내었다. 수용성인 젬시타빈을 탑재한 채로 방광 시뮬레이션 모델을 통해 젤 침식 및 약물 방출을 조사하였다. 4회 반복시험 후 남아있는 양을 관찰하였을 때 HHA 첨가 하이드로젤 및 PLX 하이드로젤이 각각 74.6% 및 57.8%로 나타났으며, 약물 방출은 확산 및 침식으로 제어되었다. 따라서 HHA 첨가 하이드로젤은 방광 내 주입을 위한 유망한 시스템으로 판단된다. Poloxamer 407 (PLX) hydrogel has been used as a drug delivery system for intravesical instillation, but it has a limitation of insufficient gel strength. Here, to modulate the viscosity and strength of hydrogel, various polymers were screened. Their effect on viscosity decreased in the following order: high molecular-weight hyaluronic acid (HHA; 33.524 Pa·s) > hydroxypropyl methylcellulose > chitosan > low-molecular weight HA > sodium alginate > carbopol (24.332 Pa·s). Polymer addition hardly altered the thermo-reversible property of hydrogels; the gelation temperature was 21.0–25.3 ℃ and gelation time was 17.28–28.32 s. With gemcitabine as a water-soluble ingredient, gel erosion and drug release were examined using an in vitro bladder simulation model. After four repeated cycles of filling and emptying, the remaining fraction of HHA-added hydrogel and PLX hydrogel was 74.6% and 57.8%, respectively. Furthermore, drug release was diffusion- and erosion-controlled. Thus, HHA-added hydrogel is a promising system for intravesical instillation.
Neurofibromatosis type I: points to be considered by general pediatricians
Kang, Eungu,Yoon, Hee Mang,Lee, Beom Hee The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.4
Neurofibromatosis type 1 (NF1), a prevalent genetic disease that is transmitted in an autosomal dominant manner, is characterized by multiple cutaneous cafe-au-lait spots and neurofibromas as well as various degrees of neurological, skeletal, and neoplastic manifestations. The clinical features of NF1 increase in frequency with age, while the clinical diagnosis can remain undetermined in some pediatric patients. Importantly, affected patients are at risk for developing tumors of the central and peripheral nervous system. Therefore, adequate counseling for genetic testing, age-appropriate surveillance, and management are important. This review suggests several issues that should be considered to help general pediatricians provide adequate clinical care and genetic counseling to patients with NF1 and their families.
Current diagnosis and image-guided reduction for intussusception in children
Hwang Jisun,Yoon Hee Mang,Kim Pyeong Hwa,Jung Ah Young,Lee Jin Seong,Cho Young Ah 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.1
Intussusception involves an invagination of the proximal bowel into the distal bowel, with ileocolic intussusception being the most common type. However, a diagnostic delay can lead to intestinal ischemia, bowel infarction, or even death; therefore, its early diagnosis and management are important. The primary role of abdominal radiography is to detect pneumoperitoneum or high-grade bowel obstruction in cases of suspected intussusception, and ultrasonography is the modality of choice for its diagnosis. Nonoperative enema reduction, the treatment of choice for childhood intussusception in cases without signs of perforation or peritonitis, can be safely performed with a success rate of 82%. Enema reduction can be performed in various ways according to image guidance method (fluoroscopy or ultrasonography) and reduction medium (liquid or air). Successful enema reduction is less likely to be achieved in children with a longer symptom duration, younger age, lethargy, fever, bloody diarrhea, unfavorable radiologic findings (small bowel obstruction, trapped fluid, ascites, absence of flow in the intussusception, intussusception in the left-sided colon), and pathological lead points. This review highlights the current concepts of intussusception diagnosis, nonsurgical enema reduction, success rates, predictors of failed enema reduction, complications, and recurrence to guide general pediatricians in the management of childhood intussusception.
Jisun Hwang,Hee Mang Yoon,Pyeong Hwa Kim,Jung-Man Namgoong,Seak Hee Oh,Ah Young Jung,Jin Seong Lee,Young Ah Cho 대한영상의학회 2022 대한영상의학회지 Vol.83 No.5
The Kasai portoenterostomy is the first-line treatment for the restoration of the flow of bile to the small intestine in patients with biliary atresia. Various complications can occur after Kasai portoenterostomy, including ascending cholangitis, biliary cirrhosis, and portal hypertension. Of these potential complications, ascending cholangitis in the most common. In cases of patients having uncontrolled complications due to progressive liver cirrhosis, portal hypertension, or progressive hyperbilirubinemia, liver transplantation is the indicated as treatment plan. Lifelong follow-up, particularly involving imaging studies, is important for the identification of various complications arising from biliary atresia after Kasai portoenterostomy. Additionally, imaging studies play a crucial role in the evaluation of potential liver donors and recipients. US is a key imaging modality utilized in the management of patients who undergo Kasai portoenterostomy, while CT and MRI are imperative to obtaining an accurate diagnosis.
Kim Pyeong Hwa,Yoon Hee Mang,Kim Jeong Rye,Hwang Jae-Yeon,Choi Jin-Ho,Hwang Jisun,Lee Jaewon,Sung Jinkyeong,Jung Kyu-Hwan,Bae Byeonguk,Jung Ah Young,Cho Young Ah,Shim Woo Hyun,Bak Boram,Lee Jin Seong 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.11
Objective: To develop a deep-learning-based bone age prediction model optimized for Korean children and adolescents and evaluate its feasibility by comparing it with a Greulich-Pyle-based deep-learning model. Materials and Methods: A convolutional neural network was trained to predict age according to the bone development shown on a hand radiograph (bone age) using 21036 hand radiographs of Korean children and adolescents without known bone development-affecting diseases/conditions obtained between 1998 and 2019 (median age [interquartile range {IQR}], 9 [7–12] years; male:female, 11794:9242) and their chronological ages as labels (Korean model). We constructed 2 separate external datasets consisting of Korean children and adolescents with healthy bone development (Institution 1: n = 343; median age [IQR], 10 [4–15] years; male: female, 183:160; Institution 2: n = 321; median age [IQR], 9 [5–14] years; male: female, 164:157) to test the model performance. The mean absolute error (MAE), root mean square error (RMSE), and proportions of bone age predictions within 6, 12, 18, and 24 months of the reference age (chronological age) were compared between the Korean model and a commercial model (VUNO Med-BoneAge version 1.1; VUNO) trained with Greulich-Pyle-based age as the label (GP-based model). Results: Compared with the GP-based model, the Korean model showed a lower RMSE (11.2 vs. 13.8 months; P = 0.004) and MAE (8.2 vs. 10.5 months; P = 0.002), a higher proportion of bone age predictions within 18 months of chronological age (88.3% vs. 82.2%; P = 0.031) for Institution 1, and a lower MAE (9.5 vs. 11.0 months; P = 0.022) and higher proportion of bone age predictions within 6 months (44.5% vs. 36.4%; P = 0.044) for Institution 2. Conclusion: The Korean model trained using the chronological ages of Korean children and adolescents without known bone development-affecting diseases/conditions as labels performed better in bone age assessment than the GP-based model in the Korean pediatric population. Further validation is required to confirm its accuracy.
박정규 ( Jeong Kyu Park ),윤석근 ( Seok Geun Yoon ),김성욱 ( Sung Ug Kim ),이정헌 ( Jeong Heon Lee ),김종현 ( Jong Hyeon Kim ),이승연 ( Seung Yeun Yi ),정소망 ( So Mang Jeong ),류철희 ( Chul Hee Rheu ),김종덕 ( Jong Duk Kim ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
From January 1998 to December 2002, 3,259 cases of uterine myoma were treated at the department of Obstetrics and Gynecology, Chunbuk National University Hospital. A clinico-stastical study of uterine myoma was perfomed to analyse the clinical characteris
Hwang Jae-Yeon,Choi Young Hun,Yoon Hee Mang,Ryu Young Jin,Shin Hyun Joo,Kim Hyun Gi,Lee So Mi,You Sun Kyung,Park Ji Eun 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.7
Objective: The purposes of this study were to analyze the radiation doses for pediatric abdominopelvic and chest CT examinations from university hospitals in Korea and to establish the local diagnostic reference levels (DRLs) based on the body weight and size. Materials and Methods: At seven university hospitals in Korea, 2494 CT examinations of patients aged 15 years or younger (1625 abdominopelvic and 869 chest CT examinations) between January and December 2017 were analyzed in this study. CT scans were transferred to commercial automated dose management software for the analysis after being de-identified. DRLs were calculated after grouping the patients according to the body weight and effective diameter. DRLs were set at the 75th percentile of the distribution of each institution’s typical values. Results: For body weights of 5, 15, 30, 50, and 80 kg, DRLs (volume CT dose index [CTDIvol]) were 1.4, 2.2, 2.7, 4.0, and 4.7 mGy, respectively, for abdominopelvic CT and 1.2, 1.5, 2.3, 3.7, and 5.8 mGy, respectively, for chest CT. For effective diameters of < 13 cm, 14–16 cm, 17–20 cm, 21–24 cm, and > 24 cm, DRLs (size-specific dose estimates [SSDE]) were 4.1, 5.0, 5.7, 7.1, and 7.2 mGy, respectively, for abdominopelvic CT and 2.8, 4.6, 4.3, 5.3, and 7.5 mGy, respectively, for chest CT. SSDE was greater than CTDIvol in all age groups. Overall, the local DRL was lower than DRLs in previously conducted dose surveys and other countries. Conclusion: Our study set local DRLs in pediatric abdominopelvic and chest CT examinations for the body weight and size. Further research involving more facilities and CT examinations is required to develop national DRLs and update the current DRLs.