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정태기,김현대,류재춘,최석구,유원상 인제대학교 1993 仁濟醫學 Vol.14 No.4
Prostaglandin 합성을 촉진하는 새로운 강압약인 cicletanine의 강압효과를 진료실 혈압과 24시간 활동혈압으로 평가했을 때 상당한 차이를 보여 그 이유를 검토해 보았다. To evaluate antihypertensive effect of cicletanine with both clinic and ambulatory blood pressure monitoring, 10 male hypertensive patients were administered cicletanine, a new antihypertensive stimulating prostaglandin synthesis, in 100∼200 mg daily for 12 weeks. The following were the results. 1.Mean of clinic BP decreased from 161/98 mmHg to 153/98 mmHg. 2.Mean of ambulatory BP changed from 140/91 mmHg to 153/99 mmHg. 3.Side reactions were mild, namely indigestion and constipation. 4.Discrepancy between clinic and ambulatory BP were discussed. In conclusion cicletanine revealed slight antihypertensive effect with clinic blood pressure, but failed to confirm it with ambulatory blood pressure.
許麟洙,金容煥,柳泰錫 慶尙大學校 1976 論文集 Vol.15 No.-
In order to elucidate the influence of various factors on the insecticidal activity of the chloroform extract of Polygonum species, a brief experiment was carred out. The results obtained were as follows. 1. Physicochemical nature of the extreact: a) Stable to temperature (heat) and sunlight. b) Stable to pH (1.5-11.0) c) Soluble in organic solvents, insoluble in other solvents. d) Stable to KIO, TCA, HCI, NaCl, NaOH and KOH. 2. Potency: a) Most effective in trituration b) Increased by higher purity c) Augmented when suspended or emulsified the extract with kerasin and soap solution d) Augmented when the extract was chlorinated.
실험동물에 대한 Ranuculus Sp. 와 Polygonum Sp. 의 치사량측정에 관한 연구
유태석 경상대학교 축산진흥연구소 1978 畜産振興硏究所報 Vol.6 No.1
Lethality of Ranunculus sp. (R. S.) and Polygonum sp. (P. S.) on mouse, frog, guinea pig and rabbit was determined. Intraperitoneal administration in graded does of Ranunculus sp. and Polygonum sp. showed MLD, LD 50 or LD 100 on animals. Throughout the experiment, the following results were obtained and summarized here. 1. The MLD of Ranunculus sp. and Polygonum sp. in experimental animals (mouse, frog, guinea pig and rabbit) was 1.4ml/kg of body weight. 2. The LD 100 of R. S. and P. S. in experimental animals was 2.0 ml/kg of body weight. 3. The LD 50 of R. S. in mouse, guinea pig and rabbit was 1.5 ml/kg of body weight. 4. In frog LD 50 of R. S. was 1.7 ml/kg of body weight 5. The LD 50 of P. S. in experimental animals was about 1.6-1.7 ml/kg of body weight.
Yoo, Yeon Hwa,Kim, Hak-Sun,Lee, Young Han,Yoon, Choon-Sik,Paek, Mun Young,Yoo, Hanna,Kannengiesser, Stephan,Chung, Tae-Sub,Song, Ho-Taek,Suh, Jin-Suck,Kim, Sungjun The Korean Society of Radiology 2015 KOREAN JOURNAL OF RADIOLOGY Vol.16 No.5
<P><B>Objective</B></P><P>To assess whether multi-echo Dixon magnetic resonance (MR) imaging with simultaneous T2* estimation and correction yields more accurate fat-signal fraction (FF) measurement of the lumbar paravertebral muscles, in comparison with non-T2*-corrected two-echo Dixon or T2*-corrected three-echo Dixon, using the FF measurements from single-voxel MR spectroscopy as the reference standard.</P><P><B>Materials and Methods</B></P><P>Sixty patients with low back pain underwent MR imaging with a 1.5T scanner. FF mapping images automatically obtained using T2*-corrected Dixon technique with two (non-T2*-corrected), three, and six echoes, were compared with images from single-voxel MR spectroscopy at the paravertebral muscles on levels L4 through L5. FFs were measured directly by two radiologists, who independently drew the region of interest on the mapping images from the three sequences.</P><P><B>Results</B></P><P>A total of 117 spectroscopic measurements were performed either bilaterally (57 of 60 subjects) or unilaterally (3 of 60 subjects). The mean spectroscopic FF was 14.3 ± 11.7% (range, 1.9-63.7%). Interobserver agreement was excellent between the two radiologists. Lin's concordance correlation between the spectroscopic findings and all the imaging-based FFs were statistically significant (<I>p</I> < 0.001). FFs obtained from the T2*-corrected six-echo Dixon sequences showed a significantly better concordance with the spectroscopic data, with its concordance correlation coefficient being 0.99 and 0.98 (<I>p</I> < 0.001), as compared with two- or three-echo methods.</P><P><B>Conclusion</B></P><P>T2*-corrected six-echo Dixon sequence would be a better option than two- or three-echo methods for noninvasive quantification of lumbar muscle fat quantification.</P>
Yoo, Chae-Kyoung,Cho, In-Cheol,Lee, Jae-Bong,Jung, Eun-Ji,Lim, Hyun-Tae,Han, Sang-Hyun,Lee, Sung-Soo,Ko, Moon-Suck,Kang, Taeyoung,Hwang, Joon-Ho,Park, Yong Sang,Park, Hee-Bok American Physiological Society 2012 PHYSIOLOGICAL GENOMICS Vol.44 No.13
<P>Clinical-chemical traits are essential when examining the health status of individuals. The aim of this study was to identify quantitative trait loci (QTL) and the associated positional candidate genes affecting clinical-chemical traits in a reciprocal F(2) intercross between Landrace and Korean native pigs. Following an overnight fast, 25 serum phenotypes related to clinical-chemical traits (e.g., hepatic function parameters, renal function parameters, electrolyte, lipids) were measured in >970 F(2) progeny. All experimental samples were subjected to genotyping analysis using 165 microsatellite markers located across the genome. We identified eleven genome-wide significant QTL in six chromosomal regions (SSC 2, 7, 8, 13, 14, and 15) and 59 suggestive QTL in 17 chromosomal regions (SSC 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, and 18). We also observed significant effects of reciprocal crosses on some of the traits, which would seem to result from maternal effect, QTL on sex chromosomes, imprinted genes, or genetic difference in mitochondrial DNA. The role of genomic imprinting in clinical-chemical traits also was investigated. Genome-wide analysis revealed a significant evidence for an imprinted QTL in SSC4 affecting serum amylase levels. Additionally, a series of bivariate linkage analysis provided strong evidence that QTL in SSC 2, 13, 15, and 18 have a pleiotropic effect on clinical-chemical traits. In conclusion, our study detected both novel and previously reported QTL influencing clinical-chemical traits in pigs. The identified QTL together with the positional candidate genes identified here could play an important role in elucidating the genetic structure of clinical-chemical phenotype variation in humans and swine.</P>
김태오 ( Tae Oh Kim ),정유석 ( Yoo Suck Jung ),김지영 ( Ji Young Kim ),배우형 ( Woo Hyung Bae ),김성일 ( Sung Il Kim ),이창훈 ( Chang Hun Lee ),곽임수 ( Ihm Soo Kwak ),나하연 ( Ha Yeon Rha ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.4
Polymyositis is non-hereditary, autoimmune rheumatic disease characterized by progressive symmetrical proximal muscle weakness due to chronic inflammation of skeletal muscles. Its definite causes are unknown, genetic and environmental factors including some viral infections such as hepatitis C virus were associated with development of autoimmunity. Clinical symptoms are symmetrical proximal muscle weakness, arthritis, interstitial lung disease, heart failure and gastrointestinal disturbance. We experienced a case of polymyositis which involved liver and developed chronic hepatitis confirmed by liver biopsy.