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A library of TAL effector nucleases spanning the human genome
Kim, Yongsub,Kweon, Jiyeon,Kim, Annie,Chon, Jae Kyung,Yoo, Ji Yeon,Kim, Hye Joo,Kim, Sojung,Lee, Choongil,Jeong, Euihwan,Chung, Eugene,Kim, Doyoung,Lee, Mi Seon,Go, Eun Mi,Song, Hye Jung,Kim, Hwangbeo Nature Publishing Group, a division of Macmillan P 2013 Nature biotechnology Vol.31 No.3
Transcription activator–like (TAL) effector nucleases (TALENs) can be readily engineered to bind specific genomic loci, enabling the introduction of precise genetic modifications such as gene knockouts and additions. Here we present a genome-scale collection of TALENs for efficient and scalable gene targeting in human cells. We chose target sites that did not have highly similar sequences elsewhere in the genome to avoid off-target mutations and assembled TALEN plasmids for 18,740 protein-coding genes using a high-throughput Golden-Gate cloning system. A pilot test involving 124 genes showed that all TALENs were active and disrupted their target genes at high frequencies, although two of these TALENs became active only after their target sites were partially demethylated using an inhibitor of DNA methyltransferase. We used our TALEN library to generate single- and double-gene-knockout cells in which NF-κB signaling pathways were disrupted. Compared with cells treated with short interfering RNAs, these cells showed unambiguous suppression of signal transduction.
철도전기실의 초박형 액체단열재 적용을 통한 에너지 절감효과
김형철(Hyungchul Kim),장정훈(Junghoon Jang),신승권(Sungkwon Shin),박용섭(Yongsub Park),김상암(Sangam Kim),김형래(Hyeong Rae kim),현병수(Byungsoo Hyun),김진호(Jinho Kim) 대한전기학회 2015 전기학회논문지 Vol.64 No.1
In this paper, because of global environmental problems such as energy shortage and abnormal climate, green energy development and energy saving technology development is being magnified. Heat insulation, the most basic and traditional energy saving method, is highly expected. Especially, simple and advanced heat insulation technique based on Nano material is promising future technology. The railway system also requires heat insulation. Especially, traditional heat insulator such as glass wool has been adopted frequently to rolling stock. The heat insulator is also adopted in general railway service buildings. Take account of cost-effective heat blocking performance, the heat insulator shall be adopted in diverse fields such as electric power, railroad, signal and communication. The only and direct solution for this problem is installing heat insulator with outstanding endurance, corrosion resistance and heat resistance to block outer heat Upgrading heat specification of equipment can be a solution, but since price and maintenance cost rise severely, this plan might be incongruous. In this research, energy saving effect of ultrathin heat insulator film was demonstrated by installing the film on roof of electrical room.
Biotransformation of Eugenol to Bis-eugenol by Kalopanax pictus Cell Culture
Kim, Bong-Gyu,Kim, Jae Young,Yi, Yongsub,Lim, Yoongho The Korean Society for Applied Biological Chemistr 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.5
So far, the production of bis-eugenol has been conducted by chemical synthesis. However, because chemical synthesis of bis-eugenol has disadvantages such as regioselectivity and low yield, an environmentally friendly production of bis-eugenol by biological synthesis has become attractive. In the present study, bis-eugenol was produced using Kalopanax pictus callus culture. High-performance liquid chromatography analysis of reaction product revealed a new peak, whose structure was determined to be bis-eugenol by nuclear magnetic resonance spectroscopy. After 18 h of biotransformation using K. pictus cell, 16.3 mg/L of biseugenol was produced without any byproducts. This is the first report on production of bis-eugenol by biotransformation using plant cell culture.
Kyoungmin Kim,Jung-Hoon Kim,Yongsub Yoon,신동욱 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.1
Li0.33La0.55TiO3 solid electrolytes with a pure phase were synthesized by the citric acid-supported sol-gelmethod and then sintered under controlled redox atmospheres of air, argon and hydrogen. Although ofsimilar morphology and relative density, Li0.33La0.55TiO3 samples sintered under reduction atmosphere suchas argon and hydrogen exhibited a tetragonal structure with lattice distortion. The distortion and volumeexpansion of the crystal lattice was identified as originating from the transformation of the Ti valence state,and this was more clearly observed under sintering of the hydrogen atmosphere. The qualitative analysisof the Ti valence state using an X-ray Photoelectron Spectroscopy experiment was performed and indi-cated that the largest amount of Ti3+(18.6%) was formed in the Li0.33La0.55TiO3 samples sintered underhydrogen atmosphere. The relationship between the lattice distortion and the lithium ion conductivity of theLi0.33La0.55TiO3 sintered under different atmospheres is also discussed on the basis of the lattice distortion.