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Liujun Shi,Wei Hu,Yongjin He,Yu Ke,Gang Wu,Meng Xiao,Langhuan Huang,Shaozao Tan 한국고분자학회 2020 Macromolecular Research Vol.28 No.4
Amphiphilic triblock copolymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) as a hydrophobic block and poly(ethylene glycol) (PEG) as a hydrophilic block, were successfully synthesized, with an aim to broaden the potential application of PHBV in biomedical areas. Isophorone diisocyanate having two different reactive isocyanate groups was used as the coupling agent. Telechelic hydroxylated PHBV was prepared by alcoholysis reaction, isocyanate modified and finally reacted with PEG. Molecular weight of triblock copolymer increased with the increasing molecular weight of PHBV-diol and PEG. The length of the PHBV block and PEG block had a great influence on the crystallization behavior of the triblock copolymers. Thermal degradation temperature of PHBV segment enhanced greatly. The triblock copolymer showed a tendency toward formation of aggregation in aqueous solution with a critical aggregation concentration of 5.01×10-4 g·L−1, and the rod-shape assembly with a uniform hydrophilic shell might be employed as hydrophobic drug delivery systems.
E-quality control: A support vector machines approach
Tseng, Tzu-Liang (Bill),Aleti, Kalyan Reddy,Hu, Zhonghua,Kwon, Yongjin (James) Society for Computational Design and Engineering 2016 Journal of computational design and engineering Vol.3 No.2
The automated part quality inspection poses many challenges to the engineers, especially when the part features to be inspected become complicated. A large quantity of part inspection at a faster rate should be relied upon computerized, automated inspection methods, which requires advanced quality control approaches. In this context, this work uses innovative methods in remote part tracking and quality control with the aid of the modern equipment and application of support vector machine (SVM) learning approach to predict the outcome of the quality control process. The classifier equations are built on the data obtained from the experiments and analyzed with different kernel functions. From the analysis, detailed outcome is presented for six different cases. The results indicate the robustness of support vector classification for the experimental data with two output classes.
Friedline, Randall H.,Ko, Hwi Jin,Jung, Dae Young,Lee, Yongjin,Bortell, Rita,Dagdeviren, Sezin,Patel, Payal R.,Hu, Xiaodi,Inashima, Kunikazu,Kearns, Caitlyn,Tsitsilianos, Nicholas,Shafiq, Umber,Shultz The Federation of American Societies for Experimen 2016 The FASEB Journal Vol.30 No.3
<P>Obesity is characterized by a dysregulated immune system, which may causally associate with insulin resistance and type 2 diabetes. Despite widespread use of nonobese diabetic (NOD) mice, NOD with severe combined immunodeficiency (scid) mutation (SCID) mice, and SCID bearing a null mutation in the IL-2 common chain receptor (NSG) mice as animal models of human diseases including type 1 diabetes, the underlying metabolic effects of a genetically altered immune system are poorly understood. For this, we performed a comprehensive metabolic characterization of these mice fed chow or after 6 wk of a high-fat diet. We found that NOD mice had similar to 50% less fat mass and were 2-fold more insulin sensitive, as measured by hyperinsulinemic-euglycemic clamp, than C57BL/6 wild-type mice. SCID mice were also more insulin sensitive with increased muscle glucose metabolism and resistant to diet-induced obesity due to increased energy expenditure (similar to 10%) and physical activity (similar to 40%) as measured by metabolic cages. NSG mice were completely protected from diet-induced obesity and insulin resistance with significant increases in glucose metabolism in peripheral organs. Our findings demonstrate an important role of genetic background, lymphocytes, and cytokine signaling in diet-induced obesity and insulin resistance.</P>
Lee, Eunjung,Jung, Dae Young,Kim, Jong Hun,Patel, Payal R.,Hu, Xiaodi,Lee, Yongjin,Azuma, Yoshihiro,Wang, Hsun-Fan,Tsitsilianos, Nicholas,Shafiq, Umber,Kwon, Jung Yeon,Lee, Hyong Joo,Lee, Ki Won,Kim, The Federation of American Societies for Experimen 2015 The FASEB Journal Vol.29 No.8
<P>Insulin resistance is a major characteristic of obesity and type 2 diabetes, but the underlying mechanism is unclear. Recent studies have shown a metabolic role of capsaicin that may be mediated <I>via</I> the transient receptor potential vanilloid type-1 (TRPV1) channel. In this study, TRPV1 knockout (KO) and wild-type (WT) mice (as controls) were fed a high-fat diet (HFD), and metabolic studies were performed to measure insulin and leptin action. The TRPV1 KO mice became more obese than the WT mice after HFD, partly attributed to altered energy balance and leptin resistance in the KO mice. The hyperinsulinemic-euglycemic clamp experiment showed that the TRPV1 KO mice were more insulin resistant after HFD because of the ∼40% reduction in glucose metabolism in the white and brown adipose tissue, compared with that in the WT mice. Leptin treatment failed to suppress food intake, and leptin-mediated hypothalamic signal transducer and activator of transcription (STAT)-3 activity was blunted in the TRPV1 KO mice. We also found that the TRPV1 KO mice were more obese and insulin resistant than the WT mice at 9 mo of age. Taken together, these results indicate that lacking TRPV1 exacerbates the obesity and insulin resistance associated with an HFD and aging, and our findings further suggest that TRPV1 has a major role in regulating glucose metabolism and hypothalamic leptin’s effects in obesity.—Lee, E., Jung, D. Y., Kim, J. H., Patel, P. R., Hu, X., Lee, Y., Azuma, Y., Wang, H.-F., Tsitsilianos, N., Shafiq, U., Kwon, J. Y., Lee, H. J., Lee, K. W., Kim, J. K. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance.</P>
Rapid fabrication of NiFe(OH)x/Fe0.2Co-Se complexes for oxygen evolution reaction electrocatalysis
Kang Gao,Miao Xu,Chuankun Zhang,Haiming Huang,Dongming Cai,Minglei Cao,Jun Wu,Chengrui Wu,Yongjin Hu,Rui Tong 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-
Exploiting the inexpensive and efficient oxygen evolution reaction (OER) electrocatalysts is crucial forimproving the efficiency of electrocatalytic water splitting (EWS), since the slow 4-electron OER processis a rate-limiting step in EWS. Herein, we prepared the NiFe(OH)x/Fe0.2Co-Se complexes on carbon paper(CP) via an easy two-step electrochemical deposition strategy. By varying the doping amount of Fe andthe deposition time of Fe0.2Co-Se, the OER property of NiFe(OH)x/Fe0.2Co-Se/CP was optimized to the best:only requiring low overpotentials of 243 and 277 mV at the current density of 20 and 100 mA/cm2 (j20and j100) and a small Tafel slope of 36.8 mV/dec, along with a terrific long-term durability in 1 M KOH. According to the experimental results, the rich exposed active sites, improved intrinsic site activityand enhanced electrical conductivity lead to the superior OER performance. Our work will provide someinspiration for designing other metal selenide/hydroxide heterostructures for other energy conversion orstorage applications.