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Zheng Qing-Xiang,Jiang Xiu-Min,Wang Hai-Wei,Ge Li,Lai Yu-Ting,Jiang Xin-Yong,Chen Fan,Huang Ping-Ping 한국미생물학회 2021 The journal of microbiology Vol.59 No.9
Probiotics effectively prevent and improve metabolic diseases such as diabetes by regulating the intestinal microenvironment and gut microbiota. However, the effects of probiotics in gestational diabetes mellitus are not clear. Here, we showed that probiotic supplements significantly improved fasting blood glucose in a gestational diabetes mellitus rat model. To further understand the mechanisms of probiotics in gestational diabetes mellitus, the gut microbiota were analyzed via 16S rRNA sequencing. We found that compared with the normal pregnant group, the gestational diabetes mellitus rats had decreased diversity of gut microbiota. Moreover, probiotic supplementation restored the diversity of the gut microbiota in gestational diabetes mellitus rats, and the gut microbiota structure tended to be similar to that of normal pregnant rats. In particular, compared with gestational diabetes mellitus rats, the abundance of Firmicutes and Actinobacteria was higher after probiotic supplementation. Furthermore, activating carbohydrate metabolism and membrane transport pathways may be involved in the potential mechanisms by which probiotic supplements alleviate gestational diabetes mellitus. Overall, our results suggested that probiotic supplementation might be a novel approach to restore the gut microbiota of gestational diabetes mellitus rats and provided an experimental evidence for the use of probiotic supplements to treat gestational diabetes melitus.
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Gustav Wik,Yong Huang,Tongjun Zeng,Shanshan Qu,Yu Zheng,Jiping Zhang,Xinsheng Lai,Chunzhi Tang,Baoci Shan 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.1
Subtraction of functional magnetic resonance imaging activity data results in a loss of information regarding possible general patterns of brain activation under experimental conditions. We, hence, reanalyzed previous Waiguan acupuncture data to qualitatively elucidate patterns of cerebral correlations to acupuncture and placebo conditions. Healthy individuals (n=24) were randomly allocated to true and sham Waiguan acupuncture and to true and sham needling of a nonacupuncture point (nonacupoint), and functional magnetic resonance imaging scans were performed during stimulation. Statistical parametric mapping group comparisons revealed clearly different patterns of activation between Waiguan stimulation and the corresponding stimulation of a nonacupoint. The former condition produced less neocortical activation than the nonacupoint stimulation. Cerebellar activation was typically seen only during true Waiguan acupuncture. The reduced neocortical activity during both true and sham Waiguan acupuncture may indicate that this point activates anticorrelated networks, with possible intrinsic healing properties. Cerebellar activation during true Waiguan acupuncture implies the region's influence on healing networks.
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Peng-yu Zhu,Yong-lai Zheng,Wen-bin Luo,Jia Kou,Ru-xue Zhang,Shu-xin Deng 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.1
An experimental investigation on chloride diffusion in structural concrete under the cyclic impact loading is conducted. Effects of magnitudes and loading times are studied. Relationship between damage coefficients and chloride diffusion coefficients is obtained. The cyclic impact loading causes the initiation of new cracks and the propagation of existing cracks, which brings an obvious promotion for chloride diffusion. There should be a damage threshold. If the magnitude of the external loading is large enough to make the damage exceed the threshold, initiation and propagation of cracks become quite significant and chloride diffusion can be greatly promoted. With the increase of the damage coefficient, the chloride diffusion coefficient increases. The increasing rates decrease with long immersion times. Relationship curves of damage coefficients and chloride diffusion coefficients show a good correlation and can be well described with power functions.
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