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박용민 ( Yong Mean Park ) 대한소아알레르기호흡기학회 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4
Eosinophilia is common feature in many diseases, including allergic diseases. There are many factors involved in the survival and the death of eosinophil. Apoptosis is the most common form of physiological cell death and a necessary process to maintain cell numbers in multicellular organisms. It has been directly demonstrated that eosinophil apoptosis is delayed in allergic inflammatory sites, and that this mechanism contributes to the expansion of eosinophils in tissue. Overexpression of interleukin-5 appears to be crucial for delaying eosinophil apoptosis. Besides survival cytokines, eosinophil apoptosis is also regulated by death factor. Recent observations suggest a role for mitochondria in conducting eosinophil apoptosis, although the mechanisms that trigger mitochondria to release proapoptotic factors remain less clear. Acceleration of eosinophil apoptosis can be achieved by decreased expression of eosinophil survival factors, and promotion of death signals. However, many previous studies on the regulation of apoptosis have utilized cell lines which may not directly represent cells within the in vivo environment. Therefore, the control of eosinophil apoptosis can be another therapeutic strategy in allergic diseases. [Pediatr Allergy Respir Dis(Korea) 2010;20:219-225]
박용민 ( Yong Mean Park ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.2
Atopic dermatitis (AD) is one of the most common chronic childhood skin diseases affecting up to 30% of children in the Korea. The point prevalence of AD has increased based on validated questionnaires in the most recent update of the International Study of Asthma and Allergies in Childhood. The evaluation of risk factors of AD is very important to develop the therapeutic strategies of AD. Many risk factors were studied to evaluate the relationship with the prevalence of AD. However, the results were quite different depending on methods of study, study population, and country. The further objective and well designed prospective epidemiologic studies are required to confirm these outcomes because the environmental and risk factors may be different among the countries according to their living cultures. [Pediatr Allergy Respir Dis(Korea) 2011;21:74-77]
박용민 ( Yong Mean Park ) 대한소아알레르기호흡기학회 2006 소아알레르기 및 호흡기학회지 Vol.16 No.3
Atopic dermatitis is a common chronic inflammatory skin disease often preceding the development of asthma and allergic disorders, such as food allergy or allergic rhinoconjunctivitis. The incidence of atopic dermatitis is increasing, and this poses a major burden on health care costs. The pathophysiology of atopic dermatitis has long remained enigmatic, but much scientific effort has been invested in elucidating the genetic background and the immunological mechanisms underlying atopic dermatitis. Pathophysiology involves a complex series of interactions between resident and infiltrating cells orchestrated by proinflammatory cytokines and chemokines. A deficiency of antimicrobial peptides might contribute to the propensity for colonization or infection by microbial organisms seen in atopic dermatitis. New management approaches have evolved form advances in our understanding of the pathophysiology of this common skin disorder. [Pediatr Allergy Respir Dis(Korea) 2006;16:189-196]
박용민 ( Yong Mean Park ),정소정 ( So Chung Chung ),유광하 ( Kwang Ha Yoo ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.2
Background: Bacterial and viral infections are closely related to development and exacerbation of asthma in children. The incidences of both asthma and the latent infection of tuberculosis are increasing in Korea. This study aimed to determine whether the prevalence of the latent infection of tuberculosis could be higher in asthmatic children compared to non-allergic children. Methods: We enrolled 30 asthmatic patients and 26 nonallergic patients who visited our hospital between 2008 and 2010. Total immunoglobulin E (IgE) levels, specific IgE levels and total eosinophil counts were measured. QuantiFERON-TB Gold (Cellestis Ltd., Carnegie, Victoria, Australia) was used to check for the status of the latent tuberculosis infection in both groups. Results: The positive response rate to QuantiFERON-TB Gold was significantly higher in the asthmatic patients than in the nonallergic children (67% vs. 38%, odds ratio=3.2; 95% confidence interval, 1.07∼9.57). Conclusion: The results of this study indicate the higher incidence of the latent infection of tuberculosis in pediatric asthmatic patients. (Korean J Asthma Allergy Clin Immunol 2012;32:101-106)