http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Evaluation method based non-invasive imaging in Parkinson’s disease models
Yiseul Choi,Eun Sang Lee,Jang Woo Park,Youn Kyoung Jeong,Mijeong Park,Hye Kyung Chung 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons in the nigrostriatal system. To monitor the PD, PET with [18F]FP-CIT for the dopamine transporter (DAT) has become a widely used tool. For PD study, invaluable tools are neurotoxin-based animal models. To validate the usefulness of these animal models in DAT imaging, we discuss the evaluation of these models. To develop most classical neurotoxin PD animal models, we injected 6-hydroxydopamine (6-OHDA) into the substantia nigra of mouse or treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by oral routes. After that, [18F]FP-CIT PET imaging were acquired. The changes in [18F]FP-CIT uptake were also analyzed using PMOD software. For analysis of 6-OHDA induced PD model, we used [18F]FP-CIT binding ratio observed in the right/left striatum of the mice. Ratio average of 6-OHDA induced group was 0.477 as compare with control group ratio average 0.987. When MPTP-induced PD model were analyzed by [18F]FP-CIT binding ratio in the average of left and right striatum with the cerebellum as a reference, MPTP-treated group was 1.944 compared to average of the control group ratio 2.924. In conclusion, the evaluation of each PD model with non-invasive imaging has shown to be a valuable objective of PD research. In the future, these analyzes to preclinical drug evaluation may be suitable for development of new treatment.
The Infrared Medium-deep Survey. III. Survey of Luminous Quasars at 4.7 ≤ <i>z</i> ≤ 5.4
Jeon, Yiseul,Im, Myungshin,Kim, Dohyeong,Kim, Yongjung,Jun, Hyunsung David,Pak, Soojong,Taak, Yoon Chan,Baek, Giseon,Choi, Changsu,Choi, Nahyun,Hong, Jueun,Hyun, Minhee,Ji, Tae-Geun,Karouzos, Marios,K Published by the University of Chicago Press for t 2017 The Astrophysical journal Supplement series Vol.231 No.2
<P>We present the first results of our survey for high-redshift quasars at 5 less than or similar to z less than or similar to 5.7. The search for quasars in this redshift range has been known to be challenging due to the limitations of the filter sets used in previous studies. We conducted a quasar survey for two specific redshift ranges, 4.60 <= z <= 5.40 and 5.50 <= z <= 6.05, using multi-wavelength data that include observations made with custom-designed filters, is and iz. Using these filters and a new selection technique, we were able to reduce the fraction of interlopers. Through optical spectroscopy, we confirmed six quasars at 4.7 <= z <= 5.4 with -27.4 < M-1450 < -26.4 that recently were discovered independently by another group. We estimated black hole masses and Eddington ratios of four of these quasars from optical and near-infrared spectra, and found that these quasars are undergoing nearly Eddington-limited accretion that is consistent with the rapid growth of supermassive black holes in luminous quasars at z similar to 5.</P>
Park, Yiseul,Lee, Su-Hyun,Kang, Sang Ook,Choi, Wonyong Royal Society of Chemistry 2010 Chemical communications Vol.46 No.14
<P>Titania nanoparticles sensitized with metal-free organic dye exhibit high visible-light activities for the redox conversion of water pollutants in a wider pH range in comparison with TiO<SUB>2</SUB> sensitized with ruthenium bipyridyl complexes.</P> <P>Graphic Abstract</P><P>Titania nanoparticles sensitized with metal-free organic dye exhibit high visible-light activities for the redox conversion of water pollutants in a wider pH range in comparison with TiO<SUB>2</SUB> sensitized with ruthenium bipyridyl complexes. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b924829c'> </P>
Kim, Yiseul,Kim, Eun-Young,Son, Hee Jin,Lee, Jai-jung,Choi, Yong-ho,Rhyu, Mee-Ra Elsevier 2017 Food chemistry Vol.233 No.-
<P><B>Abstract</B></P> <P>Food protein hydrolysates created by natural fermentation have been used for centuries as food flavorings. The aim of this study was to define the key <I>umami</I>-active fraction of modernized Korean soy sauce (mJGN) and the impact thereof on bitter-masking of human sensory and bitter-taste receptor-expressing cells. We found strong correlations between taste profiles of mJGN and a contained fraction (F05). The latter contained compounds of less than 500Da, and elicits a distinct <I>umami</I> taste. Both free amino acids and Glu-enriched oligopeptides are suggested to be crucial in terms of the effects of F05 on taste. F05 not only reduced human-perceived bitterness, but also effectively suppressed the intracellular Ca<SUP>2+</SUP> response induced by caffeine in the hTAS2R43 and hTAS2R46 human bitter-taste receptor-expressing cells. This suggests that F05, a key <I>umami</I>-active fraction of mJGN, contains components that at least partially modulate human bitter-taste receptor action, improving food flavor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> F05, containing materials of molecular weight less than 500Da, plays a crucial role in imparting an <I>umami</I> taste to mJGN. </LI> <LI> Glu, Ala, Leu, Ser, and Val are the dominant free amino acids, and Glu the dominant bound amino acid, in F05. </LI> <LI> F05 bitter-masked the human responses to <SMALL>L</SMALL>-Ile, Gly-Leu, and caffeine. </LI> <LI> F05 suppressed caffeine-induced Ca<SUP>2+</SUP> responses in cells expressing the hTAS2R43 and hTAS2R46 bitter-taste receptors. </LI> </UL> </P>
Park, Yiseul,Kim, Chuhyung,Kim, Minsun,Kim, Soonhyun,Choi, Wonyong Elsevier BV 2019 Applied Catalysis B Vol.259 No.-
<P><B>Abstract</B></P> <P>Fe<SUB>2</SUB>O<SUB>3</SUB> nanorods loaded on carbon nanofiber sheet (Fe<SUB>2</SUB>O<SUB>3</SUB>/CNF) was found to be active in degrading aromatic pollutants spontaneously under the dark and ambient conditions without using any chemical reagent or external energy to assist the degradation reaction. The removal of aromatic pollutants was not caused by adsorption but by oxidative degradation since the generation of degradation intermediates and products was observed. The Fe<SUB>2</SUB>O<SUB>3</SUB>/CNF exhibited selective degradation activities for aromatic-compounds. Degradation was induced by Fe<SUB>2</SUB>O<SUB>3</SUB>/CNF only, whereas neither iron oxide nor bare CNF alone exhibited any degradation activity. The degradation on the Fe<SUB>2</SUB>O<SUB>3</SUB>/CNF was enabled only in the presence of dissolved O<SUB>2</SUB> of which reduction led to the generation of reactive oxygen species (ROS). It is proposed that electrons spontaneously transfer from aromatic-compound to O<SUB>2</SUB> viaFe<SUB>2</SUB>O<SUB>3</SUB>/CNF with initiating the oxidative degradation and the concurrent ROS generation. The direct electron transfer from organic compound to Fe<SUB>2</SUB>O<SUB>3</SUB>/CNF, which lead to oxidative degradation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Iron oxide/CNF spontaneously decomposes pollutants under dark and ambient conditions. </LI> <LI> Neither iron oxide nor CNF alone shows any degradation activity. </LI> <LI> Iron oxide/CNF exhibits selective degradation activities for aromatic compounds. </LI> <LI> Electron transfer from aromatic compounds to iron oxide/CNF causes ROS generation. </LI> <LI> Sheet form of catalyst is easily handled and recoverable. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>