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Quanjun Yang,Jingjing Li,Yili Hu,Xiaofei Tang,Lili Yu,Lihua Dong,Diandian Chen 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.6
Purpose: Lung adenocarcinoma (LA) is one of the major types of lung cancer. MicroRNAs (miRNAs) play an essential role in regulatingresponses of natural killer (NK) cells to cancer malignancy. However, the mechanism of miR-218-5p involved in the killingeffect of NK cells to LA cells remains poorly understood. Materials and Methods: The expression of miR-218-5p was examined by quantitative real-time polymerase chain reaction (qRTPCR). Serine hydroxymethyl transferase 1 (SHMT1) level was detected by qRT-PCR or western blots. Cytokines production ofinterferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) were detected by ELISA. The killing effect of NK cells to LA cells was investigatedusing lactate dehydrogenase cytotoxicity assay kit. The interaction of miR-218-5p and SHMT1 was probed by luciferaseactivity assay. Xenograft model was established to investigate the killing effect of NK cells in vivo. Results: miR-218-5p was enhanced and SHMT1 was inhibited in NK cells of LA patients, whereas stimulation of interleukin-2(IL-2) reversed their abundances. Addition of miR-218-5p reduced IL-2-induced cytokines expression and cytotoxicity in NK-92against LA cells. Moreover, SHMT1 was negatively regulated by miR-218-5p and attenuated miR-218-5p-mediated effect on cytotoxicity,IFN-γ and TNF-α secretion in IL-2-activated NK cells. In addition, miR-218-5p exhaustion inhibited tumor growth bypromoting killing effect of NK cells. Conclusion: miR-218-5p suppresses the killing effect of NK cells to LA cells by targeting SHMT1, providing a potential target forLA treatment by ameliorating NK cells function.
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Mao Minghuan,Yang Liang,Hu Jingyao,Liu Bing,Zhang Xiling,Liu Yili,Wang Ping,Li Hangyu 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
The neuronally expressed developmentally downregulated 4 (NEDD4) gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation and has been implicated in tumor growth in various cancers. Hence, in this study, we intended to characterize the functional relevance of the NEDD4-mediated Kruppel-like factor 8/microRNA-132/nuclear factor E2-related factor 2 (KLF8/miR-132/NRF2) axis in the development of bladder cancer. NEDD4 and KLF8 were overexpressed in bladder cancer tissues and were associated with poorer patient survival rates. In bladder cancer cells, NEDD4 intensified the stability and transcriptional activity of KLF8 through ubiquitination to augment cell viability and migratory ability. Our investigations revealed that NEDD4 promotes the binding of KLF8 to the miR-132 promoter region and inhibits the expression of miR-132. KLF8 inhibited the expression of miR-132 to augment the viability and migratory ability of bladder cancer cells. Furthermore, miR-132 downregulated the expression of NRF2 to restrict the viability and migratory ability of bladder cancer cells. In addition, in vivo findings verified that NEDD4 regulates the KLF8/miR-132/NRF2 axis by accelerating tumor growth and lung metastasis. In conclusion, this study highlights NEDD4 as a potential therapeutic target against tumor recurrence and metastasis in bladder cancer.
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Bimodal Phenomenon of the Stress–Strain Curve During Hot Compression of LA43M Mg–Li Alloy
Yi Li,Yanjin Guan,Hu Chen,Jiqiang Zhai,Jun Lin,Liang Chen 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.10
In this study, the samples of LA43M Mg–Li alloy were compressed to the true strains of 0.12, 0.16, 0.36 and 0.60 under300 °C and the strain rate of 0.1 s−1. Under this condition, the stress–strain curves present a special bimodal phenomenon atthe early deformation stage, which is caused by twinning and dynamic recrystallization. In the process of hot compression,extension twins generated first. Twinning accommodated strain and the glide of twinning dislocations dissipated local strainenergy, resulting in the first local stress drop. Then extension twins coarsened and devoured all the matrix, leading to thechange of grain orientation. Subsequently, dislocations accumulated at the grain boundaries and resulted in the increase instress. With further strain, dynamic recrystallization occurred, discontinuous dynamic recrystallization is the main dynamicrecrystallization mechanism. The generation of dynamic recrystallization resulted in the strain softening and leaded tothe second local stress drop. Twinning retards the occurrence dynamic recrystallization and has a crucial influence on themicrostructure development during the hot compression of LA43M.
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Weight Gain in Pregnancy, Maternal Age and Gestational Age in Relation to Fetal Macrosomia
( Yi Li ),( Qi-fei Liu ),( Dan Zhang ),( Ying Shen ),( Kui Ye ),( Han-lin Lai ),( Hai-qing Wang ),( Chuan-lai Hu ),( Qi-hong Zhao ),( Li Li ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.2
To investigate the possible risk factors related to macrosomia. Pregnant women and their newborns (n = 1041) were recruited from a cohort study in Maternal and Child Care Center of Hefei from January 2011 to July 2012. Questionnaires were applied to collect the demographic data besides the medical records. Detailed health records of the entire pregnancy were obtained using retrospective study. Meanwhile the data of neonatal outcomes was prospectively tracked. Associations between exposure risk factors and macrosomia were analyzed using Pearson’s chi squared test. Logistic regression models were used to assess the independent association between these potential predictors and macrosomia. The incidence of macrosomia of this cohort was 11.24% of which male: female = 2.55:1. Male incidence (8.07%) of macrosomia was higher than female (3.17%), p < 0.001. Body mass index (BMI) before pregnancy (pre-BMI), maternal height, parity were not independently associated with macrosomia; multiple logistic regression analysis indicated that macrosomia was mainly independently associated with weight gain in pregnancy (OR=1.14,95% CI [1.10-1.19]), maternal age (OR = 1.09,95% CI [1.03-1.15]) and gestational age (OR = 1.62,95% CI [1.31-1.99]), respectively. Our findings indicate that weight gain in pregnancy, maternal age and gestational age should be considered as independent risk factors for macrosomia.
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