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Xie, Shaozhen,Lee, Yi-Fen,Kim, Eungseok,Chen, Lu-Min,Ni, Jing,Fang, Lei-Ya,Liu, Su,Lin, Shin-Jen,Abe, Jun-Ichi,Berk, Bradford,Ho, Feng-Ming,Chang, Chawnshang National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.32
<P>Testicular orphan nuclear receptor 4 (TR4) is an orphan member of the nuclear receptor superfamily with diverse physiological functions. Using TR4 knockout (TR4(-/-)) mice to study its function in cardiovascular diseases, we found reduced cluster of differentiation (CD)36 expression with reduced foam cell formation in TR4(-/-) mice. Mechanistic dissection suggests that TR4 induces CD36 protein and mRNA expression via a transcriptional regulation. Interestingly, we found this TR4-mediated CD36 transactivation can be further enhanced by polyunsaturated fatty acids (PUFAs), such as omega-3 and -6 fatty acids, and their metabolites such as 15-hydroxyeico-satetraonic acid (15-HETE) and 13-hydroxy octa-deca dieonic acid (13-HODE) and thiazolidinedione (TZD)-rosiglitazone. Both electrophoretic mobility shift assays (EMSA) and chromatin immunoprecipitation (ChIP) assays demonstrate that TR4 binds to the TR4 response element located on the CD36 5'-promoter region for the induction of CD36 expression. Stably transfected TR4-siRNA or functional TR4 cDNA in the RAW264.7 macrophage cells resulted in either decreased or increased CD36 expression with decreased or increased foam cell formation. Restoring functional CD36 cDNA in the TR4 knockdown macrophage cells reversed the decreased foam cell formation. Together, these results reveal an important signaling pathway controlling CD36-mediated foam cell formation/cardiovascular diseases, and findings that TR4 transactivation can be activated via its ligands/activators, such as PUFA metabolites and TZD, may provide a platform to screen new drug(s) to battle the metabolism syndrome, diabetes, and cardiovascular diseases.</P>
Yi-Xin Pan,Hong-Bing Zhang,Rong-Hua Xie,Xing-Bin Liu,Min Wang 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.10
To characterize the effect of pipe inclination, low viscosity, flow rate and inlet water cut on annular flow pattern, a low viscosity oil-water two-phase annular flow in horizontal and slightly inclined (+1o, +3o and +5o) pipes with diameter of 20 mm has been experimentally investigated. A modified VOF model based on the CFD software package FLUENT was used to predict the in-situ oil fraction and pressure drop. The experimental data indicate that annular flow appears at a medium-high water cut. The slip ratio increases with flow rate increase but decreases with increasing water cut. The changes are more significant as the degree of inclination increases. Pressure drop is strongly dependent on flow rate, as it increases rapidly as inlet flow rate increase. Good agreement between the experimental data and calculated results of slip ratio and pressure drop was obtained.
( Ming Yi Zhao ),( Ming Hua Yang ),( Liang Chun Yang ),( Yan Yu ),( Min Xie ),( Shan Zhu ),( Rui Kang ),( Dao Lin Tang ),( Zhi Gang Jiang ),( Wu Zhou Yuan ),( Xiu Shan Wu ),( Li Zhi Cao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.9
HMGB1 is associated with human cancers and is an activator of autophagy which mediates chemotherapy resistance. We here show that the mRNA levels of HMGB1 are high in leukemia cells and it is involved in the progression of childhood chronic myeloid leukemia (CML). HMGB1 decreases the sensitivity of human myeloid leukemia cells K562 to anti-cancer drug induced death through up-regulating the autophagy pathway, which is confirmed by the observation with an increase in fusion of autophagosomes and autophagolysosomes. When overexpressing HMGB1, both mRNA levels of Beclin-1, VSP34 and UVRAG which are key genes involved in mammalian autophagy and protein levels of p-Bcl-2 and LC3-II are increased. Luciferase assays document that over-expression of HMGB1 increases the transcriptional activity of JNK and ERK, which may be silenced by siRNA. The results suggest that HMGB1 regulates JNK and ERK required for autophagy, which provides a potential drug target for therapeutic interventions in childhood CML. [BMB reports 2011; 44(9): 601-606]
Formula for the Total Stopping Power from 2 keV to 10 keV for a Metal
Ai-Gen Xie,Min Lai,Chen-Yi Zhang 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.1
On the basis of the range-energy relationship, the relationships (L<sub>2−10</sub>) among the total stopping power from 2 keV to 10 keV for a metal (S<sub>2−10</sub>), the energy exponent (n<sub>2−10</sub>), the primary energy at the surface (W<sub>p0</sub>), and the parameter (A<sub>2−10</sub>) were deduced. In addition, the relationships (L<sub>10−30</sub>) among the total stopping power from 10 keV to 30 keV for a metal (S<sub>10−30</sub>), the energy exponent (n<sub>10−30</sub>), Wp0 and the parameter (A<sub>10−30</sub>) were obtained. According to some relationships between the parameters of the secondary electron yield from 2 keV to 10 keV for a metal (δ<sub>2−10</sub>), the composition of the secondary electron yield from 10 keV to 30 keV for a metal (δ<sub>10−30</sub>), L<sub>2−10</sub>, and L<sub>10−30</sub>, the universal formula for expressing S<sub>2−10</sub> as a function of S<sub>10−30</sub>, δ<sub>2−10</sub>, δ<sub>10−30</sub>, the backscattered coefficient (η) from 2 keV to 10 keV, η from 10 keV to 30 keV and Wp<sub>0</sub> was deduced. The S<sub>2−10</sub> calculated from this universal formula and the S<sub>2−10</sub> measured experimentally were compared, and we conclude that the formula presented in this paper is universal for S<sub>2−10</sub>.
Conceptual design of buildings subjected to wind load by using topology optimization
Tang, Jiwu,Xie, Yi Min,Felicetti, Peter Techno-Press 2014 Wind and Structures, An International Journal (WAS Vol.18 No.1
The latest developments in topology optimization are integrated with Computational Fluid Dynamics (CFD) for the conceptual design of building structures. The wind load on a building is simulated using CFD, and the structural response of the building is obtained from finite element analysis under the wind load obtained. Multiple wind directions are simulated within a single fluid domain by simply expanding the simulation domain. The bi-directional evolutionary structural optimization (BESO) algorithm with a scheme of material interpolation is extended for an automatic building topology optimization considering multiple wind loading cases. The proposed approach is demonstrated by a series of examples of optimum topology design of perimeter bracing systems of high-rise building structures.
Conceptual design of buildings subjected to wind load by using topology optimization
Jiwu Tang,Yi Min Xie,Peter Felicetti 한국풍공학회 2014 한국풍공학회지 Vol.18 No.1
The latest developments in topology optimization are integrated with Computational Fluid Dynamics (CFD) for the conceptual design of building structures. The wind load on a building is simulated using CFD, and the structural response of the building is obtained from finite element analysis under the wind load obtained. Multiple wind directions are simulated within a single fluid domain by simply expanding the simulation domain. The bi-directional evolutionary structural optimization (BESO) algorithm with a scheme of material interpolation is extended for an automatic building topology optimization considering multiple wind loading cases. The proposed approach is demonstrated by a series of examples of optimum topology design of perimeter bracing systems of high-rise building structures.
Zhou, De,Xie, Wan-Zhuo,Hu, Ke-Yue,Huang, Wei-Jia,Wei, Guo-Qing,He, Jing-Song,Shi, Ji-Min,Luo, Yi,Li, Li,Zhu, Jing-Jing,Zhang, Jie,Lin, Mao-Fang,Ye, Xiu-Jin,Cai, Zhen,Huang, He Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Aim: To analyze the significance of different clinical factors for prognostic prediction in diffuse large B-cell lymphoma (DLBCL) patients. Methods: Two hundred and twenty-seven DLBCL patients were retrospectively reviewed. Patients were managed with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen or rituximab plus the CHOP (RCHOP) regimen. Results: Lactate dehydrogenase (LDH), ${\beta}2$-microglobulin (${\beta}2$-M), B symptoms, Ann Arbor stage and genetic subtypes were statistically relevant in predicting the prognosis of the overall survival (OS). In the CHOP group, the OS in patients with germinal center B-cell-like (GCB)(76.2%) was significantly higher than that of the non-GCB group (51.9%, P=0.032). With RCHOP management, there was no statistical difference in OS between the GCB (88.4%) and non-GCB groups (81.9%, P=0.288). Conclusion: Elevated LDH and ${\beta}2$-M levels, positive B symptoms, Ann Arbor stage III/IV, and primary nodal lymphoma indicate an unfavorable prognosis of DLBCL patients. Patients with GCB-like DLBCL have a better prognosis than those with non-GCB when treated with the CHOP regimen. The RCHOP treatment with the addition of rituximab can improve the prognosis of patients with DLBCL.
Effects of longitudinal and transverse curvatures on optimal design of shell footbridge
Shiming Liu,Bin Huang,Yi Min Xie 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.80 No.1
Shell bridges have attracted extensive interest in engineering research and practice. This paper aims to evaluate the effects of longitudinal and transverse curvatures on the optimal design of the shell bridge. For this purpose, a slant-legged steel shell footbridge with the same initial and target volumes of steel was chosen to build parametric geometric models with different curvature radii, and then topology optimization was carried out using the bi-directional evolutionary structural optimization (BESO) technique to obtain optimized designs with high structural stiffness. Furthermore, linear static analysis and eigenvalue analysis demonstrate that the displacement, von Mises effective stress, and the first-order vertical vibration frequency satisfied all the requirements of design regulations. Numerical results indicate that not only the longitudinal curvature but also the transverse curvature have a significant effect on the optimized designs of steel shell footbridge. While the mean compliance increased with the transverse curvature radius, it first decreased and then increased with the longitudinal curvature radius.