No Association Between Tea Consumption and Risk of Renal Cell Carcinoma: A Meta-analysis of Epidemiological Studies

Hu, Zheng-Hui,Lin, Yi-Wei,Xu, Xin,Chen, Hong,Mao, Ye-Qing,Wu, Jian,Xu, Xiang-Lai,Zhu, Yi,Li, Shi-Qi,Zheng, Xiang-Yi,Xie, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Objective: To evaluate the association between tea consumption and the risk of renal cell carcinoma. Methods: We searched PubMed, Web of Science and Scopus between 1970 and November 2012. Two evaluators independently reviewed and selected articles based on predetermined selection criteria. Results: Twelve epidemiological studies (ten case-control studies and two cohort studies) were included in the final analysis. In a meta-analysis of all included studies, when compared with the lowest level of tea consumption, the overall relative risk (RR) of renal cell carcinoma for the highest level of tea consumption was 1.03 (95% confidence interval [CI] 0.89-1.21). In subgroup meta-analyses by study design, there was no significant association between tea consumption and renal cell carcinoma risk in ten case-control studies using adjusted data (RR=1.08, 95% CI 0.84-1.40). Furthermore, there was no significant association in two cohort studies using adjusted data (RR=0.95, 95% CI 0.81-1.12). Conclusion: Our findings do not support the conclusion that tea consumption is related to decreased risk of renal cell carcinoma. Further prospective cohort studies are required.

Enhancement of Immunotherapeutic Effects of HPV16E7 on Cervical Cancer by Fusion with CTLA4 Extracellular Region

Yi Zheng,Yijuan Zhang,Yuandong Ma,Jun Wan,Chaofan Shi,Laiqiang Huang 한국미생물학회 2008 The journal of microbiology Vol.46 No.6

Cervical cancer is caused by infection by high-risk human papillomavirus (HPV), especially HPV16. Limitations in current treatments of cervical cancers call for the development of new and improved immunotherapies. This study aims at investigating the efficacy of a novel vaccine consisting of modified HPV 16E7 fused with human cytotoxic T-lymphocyte antigen 4 (CTLA4). The regions in HPV16 E7 gene associated with its transformation and CTL-enhanced response were modified; the resultant HPV16mE7 was fused with extracellular region of CTLA4 to generate HPVm16E7-eCTLA4 fusion protein. Binding of this fusion protein to B7 molecules expressed on antigen presenting-cells (APCs) was demonstrated. C57BL/6 (H-2b) mice immunized with low dose of the fusion protein (10 μg) produced higher titer antibody and stronger specific CTL response, and expressed higher levels of IFN-γ and IL-12, compared with those immunized with HPVm16E7 only or admixture of HPVm16E7 and CTLA4, or PBS; and were protected from lethal dose tumor challenge. Tumor growth was retarded and survival prolonged in mouse models with the fusion protein treatment. Our results demonstrate that fusion of HPV16 E7 with eCTLA4 targeting APCs resulted in enhanced immunity, and that this fusion protein may be useful for improving the efficacy of immunotherapeutic treatments of cervical cancer and other HPV16 infection-associated tumors.

Hepatitis C Virus Non-structural Protein NS4B Can Modulate an Unfolded Protein Response

Yi Zheng,Bo Gao,Li Ye,Lingbao Kong,Wei Jing,Xiaojun Yang,Zhenghui Wu,Linbai Ye 한국미생물학회 2005 The journal of microbiology Vol.43 No.6

Viral infection causes stress to the endoplasmic reticulum (ER). The response to endoplasmic reticulum stress, known as the unfolded protein response (UPR), is designed to eliminate misfolded proteins and allow the cell to recover. The role of hepatitis C virus (HCV) non-structural protein NS4B, a component of the HCV replicons that induce UPR, is incompletely understood. We demonstrate that HCV NS4B could induce activating transcription factor (ATF6) and inositol-requiring enzyme 1 (IRE1), to favor the HCV subreplicon and HCV viral replication. HCV NS4B activated the IRE1 pathway, as indicated by splicing of X box-binding protein (Xbp-1) mRNA. However, transcriptional activation of the XBP-1 target gene, EDEM (ER degradation-enhancing α-mannosidase-like protein, a protein degradation factor), was inhibited. These results imply that NS4B might induce UPR through ATF6 and IRE1- XBP1 pathways, but might also modify the outcome to benefit HCV or HCV subreplicon replication.

Ginseng-derived type I rhamnogalacturonan polysaccharide binds to galectin-8 and antagonizes its function

Yi Zheng,Yunlong Si,Xuejiao Xu,Hongming Gu,Zhen He,Zihan Zhao,Zhangkai Feng,Jiyong Su,Kevin H. Mayo,Yifa Zhou,Guihua Tai The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2

Background: Panax ginseng Meyer polysaccharides exhibit various biological functions, like antagonizing galectin-3-mediated cell adhesion and migration. Galectin-8 (Gal-8), with its linker-joined N- and C-terminal carbohydrate recognition domains (CRDs), is also crucial to these biological processes, and thus plays a role in various pathological disorders. Yet the effect of ginseng-derived polysaccharides in modulating Gal-8 function has remained unclear. Methods: P. ginseng-derived pectin was chromatographically isolated and enzymatically digested to obtain a series of polysaccharides. Biolayer Interferometry (BLI) quantified their binding affinity to Gal-8, and their inhibitory effects on Gal-8 was assessed by hemagglutination, cell migration and T-cell apoptosis. Results: Our ginseng-derived pectin polysaccharides consist mostly of rhamnogalacturonan-I (RG-I) and homogalacturonan (HG). BLI shows that Gal-8 binding rests primarily in RG-I and its β-1,4-galactan side chains, with sub-micromolar K_D values. Both N- and C-terminal Gal-8 CRDs bind RG-I, with binding correlated with Gal-8-mediated function. Conclusion: P. ginseng RG-I pectin β-1,4-galactan side chains are crucial to binding Gal-8 and antagonizing its function. This study enhances our understanding of galectin-sugar interactions, information that may be used in the development of pharmaceutical agents targeting Gal-8.

Sampling artifact in volume weighted velocity measurement. II. Detection in simulations and comparison with theoretical modeling

Zheng, Yi,Zhang, Pengjie,Jing, Yipeng American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.4

Determination of the large scale volume weighted halo velocity bias in simulations

Zheng, Yi,Zhang, Pengjie,Jing, Yipeng American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.12

3D Model Retrieval Based on A Colour+Geometry Signature

Yi-Fu Zheng,Lu Lv,Yong-Jin Liu (사)한국CDE학회 2010 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8

일본유교와 "황국(皇國) 국체" 이데올로기

( Zheng Yi ),전성곤 ( Sung Kon Jun ) 한국세계지역학회 2015 世界地域硏究論叢 Vol.33 No.2

서구와 동양을 접목시켜 새롭게 이론을 창출하는 ‘탈구축’ 이론 속에는 ‘서구와 동양의 내용 양자’를 통합하여 외부 위치로 새롭게 재구성해 내는 것이라고 보는 시각이 존재한다. 그렇지만 이 탈구축 이론은 실은 오카와 슈메이(大川周明)의 논리에서 보면 ‘반쪽 탈구축’이었다. 오카와 슈메이의 탈구축 이론 속에는 ‘제3의 입장에서’ 심급을 통해 양쪽을 무효화 시키면서 그 구조 자체를 논하기 보다는 전혀 다른 구조를 찾아내는 것으로서 나머지 반쪽 탈구축을 통해 ‘완전한 내적 공동체 논리로서 천황제’를 탈구축해 냈다. 그것은 일본의 ‘우익적사고’가 전통적 탈구축 이론과 다른 구조를 찾아내는 의미에서의 탈구축이 접목되는 특성을 가졌다는 것을 설명해 주는 것이다. 이에 대표적인 사상가가 바로 오카와 슈메이였다. 오카와 슈메이는 『대학』과 『중용』을 ‘유교사상’적 측면에서 관심을 가지면서도 종교철학적 시대적 흐름 속에서 이를 재해석해 냈다. 물론 오카와 슈메이가 사상가인가 철학자인가라는 문제라기보다는, 대학과 중용을 해독하는 방법론에서, 유교가 ‘종교, 도덕, 정치’가 공통적으로 갖고 있는 것을 ‘도(道)’라고 규정하면서 출발하는데, 그것은 종교학이나 종교사 연구에서 ‘모든 종교의 공통적 특성’을 극대화시킨 작업과 연결된다는 점이었다. 이를 통해 새롭게 학문의 지평을 여는 방식을 ‘원리’를 체현해 냈다. 오카와 슈메이는 대학에서는 ‘친민(親民)’을 ‘신민(新民)’이라고 해석하면서 수도(修道)의 ‘수(修)’를 ‘수양한다’가 아니라 ‘수양해야 하는것’으로 다르게 해석한다. 그런데 중요한 것은 개인 개인에게 모두 선험적으로 주어진 도는 수양이 중요하기 때문이었다. 그것은 바로 개인의 수양과 신민을 통한 새로운 사회 구현이 필요했기 때문이다. 이것에는 도의 수양과 성이 핵심으로 작용한다고 보았다. 이를 통해 오카와 슈메이는 유교가 서구 학자들이 주장하는 개인과 사회의 관계를 통합해주고, 유교 내부에서의 논쟁을 극복해 냈다. 그 과정에서 중(中)은, 시대적 흐름에 변화하지 않는 보편성을 가진 것으로 동시에 자아와 타자를 초월하여 존재 것을 자각하는 ‘경지’로 설명된다. 그것은 중국에서는 없어진 ‘전통과 황통이 일본의 ‘신도’ 속에 그것이 모두 포함된다고 주장했다. 그것은 바로 ‘자연적인 것=천사상과 도덕적인 것=성과 덕 그리고 평등한 것=천지인’을 통해, 황국 국체가 『대학』과 『중용』에서 찾을 수 있다는 ‘중용이데올로기’를 창출해 낸 것이었다. In the theory of “deconstruction” that creates a new theory by grafting the west and the orient, there is the point of view that ‘both sides of the west and the orient’is combined and newly restructured to “outer” location. However, this deconstruction theory was ‘half deconstruction’ in the logic of Okawa Shumei. The theory of deconstruction of Okawa Shumei did not discuss the structure itself by nullifying both sides through the instance ‘from the stance of the third party’, but found a whole new structure, deconstructing ‘the Emperor system as a ‘logic of complete internal community’ through the half deconstruction. One of the representative theorists was Okawa Shumei. He not only took an interest into “Daehak” and “Jungyong” from the aspect of ‘Confucian ideas’ but also reinterpreted the theories in a philosophy of religion and stream of times. Of course, rather than the issue that Shumei is a theorist or philosopher, the issue starts from describing the common values of ‘religion, ethics and politics’ of Confucianism as ‘morality’. This is linked to the works maximized the ‘common characteristics of all religions’ in researches on science of religion or religious history. By doing so, he materialized the ‘principle’ of how to open a new prospect in the field of the study. Okawa Shumei interpreted ‘citizens(親民)’ as ‘subjects(新民)’in Daehak and ‘ascetic(修)’ of ascetic practice(修道) as ‘have to cultivate’ rather than ‘cultivate’. Because what’s important was self-discipline of morality intuitively given to individuals. This indicated that self-discipline of morality and sincerity played a key role. By doing so, Okawa Shumei showed that Confucianism integrated the relationship between individuals and nation argued by the western scholars and overcome the disputes within Confucianism. Middle during the process has universality that does not change by the stream of times and at the same time is explained as a ‘level’ to recognize presence by transcending ego and others. It was argued that the lost ‘tradition and imperial line’ in China were all included in Japanese Shinto. In other words, based on the idea of ‘something natural = heavens thought and something moral = sincerity and virtue and something equal = heaven, land, benevolence(仁)’, the forms of the empire created ‘Jungyong ideology’ that can be found in “Daehak” and “Jungyong”.

FA/Mel@ZnO nanoparticles as drug self-delivery systems for RPE protection against oxidative stress

Yi, Caixia,Yu, Zhihai,Sun, Xin,Zheng, Xi,Yang, Shuangya,Liu, Hengchuan,Song, Yi,Huang, Xiao Techno-Press 2022 Advances in nano research Vol.13 No.1

Drug self-delivery systems can easily realize combination drug therapy and avoid carrier-induced toxicity and immunogenicity because they do not need non-therapeutic carrier materials. So, designing appropriate drug self-delivery systems for specific diseases can settle most of the problems existing in traditional drug delivery systems. Retinal pigment epithelium is very important for the homeostasis of retina. However, it is vulnerable to oxidative damage and difficult to repair. Worse still, the antioxidants can hardly reach the retina by non-invasive administration routes due to the ocular barriers. Herein, the targeted group (folic acid) and antioxidant (melatonin) have been grafted on the surface of ZnO quantum dots to fabricate a new kind of drug self-delivery systems as a protectant via eyedrops. In this study, the negative nanoparticles with size ranging in 4~6 nm were successfully synthesized. They could easily and precisely deliver drugs to retinal pigment epithelium via eyedrops. And they realized acid degradation to controlled release of melatonin and zinc in retinal pigment epithelium cells. Consequently, the structure of retinal pigment epithelium cells were stabilized according to the expression of ZO-1 and β-catenin. Moreover, the antioxidant capacity of retinal pigment epithelium were enhanced both in health mice and photic injury mice. Therefore, such new drug self-delivery systems have great potential both in prevention and treatment of oxidative damage induced retinal diseases.

Enhanced Photocatalytic Performance of Heterojunction BiOI/BiOIO3 Nanocomposites Under Simulated Solar Light

Yi Ling Qi,Xu Chun Song,Yi Fan Zheng 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.3

Novel heterostructure BiOI/BiOIO3 nanocomposites were successfully prepared through a facile deposition method at room temperature. BiOIO3 is a noncentrosymmetric compound that has an internal self-built electric field. BiOI was applied as a visible light absorber to sensitize semiconductors owing to its smallest bandgap. The coupling between BiOIO3 and BiOI can combine their advantages and improve photocatalytic properties. Compared with the single BiOI and BiOIO3, the heterostructure BiOI/BiOIO3 nanocomposites displayed a significantly enhanced photocatalytic activity for the Rhodamine B (RhB) degradation. The enhanced photocatalytic performance is deduced closely related to the formation of BiOI/BiOIO3 heterojunction interface whose presence is regarded to be a favorable factor for the transfer and separation of the photogenerated electrons and holes.