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Choi, Yewon,Lee, Sang Won,Kim, Anhye,Jang, Kyungho,Nam, Heesook,Cho, Young Lag,Yu, Kyung-Sang,Jang, In-Jin,Chung, Jae-Yong Oxford University Press 2018 The Journal of antimicrobial chemotherapy Vol.73 No.1
<P>Conclusions: LCB01-0371 is well tolerated in healthy male subjects with comparable haematology profiles to placebo, after multiple doses of up to 1200 mg twice daily for 21 days.</P>
Yewon Park,WonTae Jung,양은솔,Kyu-Yeol Nam,Woo-Ri Bong,Jaehee Kim,Kyu Yeon Kim,SeungHwan Lee,Joo-Youn Cho,Jang-Hee Hong,JaeWoo Kim 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.1
UI026 is an expectorant and antitussive agent which is a new combination of Pelargonium sidoides extract and Coptis extract. The bioactive compounds of Pelargonium sidoides and Coptisextracts were identified as epicatechin and berberine, respectively. This study evaluated the effect of food on the pharmacokinetics (PKs) and safety of UI026. A randomized, openlabel, single-dose, 2-treatment, parallel study in 12 healthy male subjects was performed. Subjects received a single oral dose of UI026 (27 mL of syrup) under a fed or fasted condition according to their randomly assigned treatment. Blood samples for the PK analysis were obtained up to 24 hours post-dose for berberine and 12 hours post-dose for epicatechin. The PK parameters were calculated by non-compartmental analysis. In the fed condition, the mean maximum plasma concentration (C max ) and mean area under the plasma concentrationtime curve from time zero to the last observed time point (AUC last ) for berberine were approximately 33% and 67% lower, respectively, compared with the fasted condition, both showing statistically significant difference. For epicatechin, the mean C max and mean AUC lastwere about 29% and 45% lower, respectively, compared to the fasting condition, neither of which showed a statistically significant difference. There were no drug-related adverse events. This finding suggests that food affects the systemic exposure and bioavailability of berberine and epicatechin.
Yewon Cheong,Ji Seung Jung,Won Jae Lee,Jun Bong Lee,Jang Won Yoon 한국예방수의학회 2020 예방수의학회지 Vol.44 No.1
Salmonella is one of the most important bacterial pathogens responsible for many zoonotic food-related infectious diseases. Quantitative detection of the foodborne Salmonella contamination in various food sources is therefore critical for preventing the related disease outbreaks. In this study, we developed and evaluated a reliable real-time polymerase chain reaction (RT-PCR) assay to detect the Salmonella contamination quantitatively. The experimental results showed that our invA gene-specific quantitative RT-PCR (qRT-PCR) assay provides a strong correlation between the Cq values and the direct plate counts of Salmonella species in the artificially formulated samples. Further study may be necessary to identify more accurate correlation and equation that can apply to Salmonella spp.
Yewon Jeong,Ga-Eun Lee,Jeong-Yun Jang,Hee-Man Yang 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
Wide-area surface decontamination is essential during the sudden release of radioisotopes to the public, such as nuclear accidents or terrorist attacks. A spray coating composed of a reversible complex between poly (vinyl alcohol) (PVA) and phenylboronic acid-grafted poly (methyl vinyl ether-alt-mono-sodium maleate) (PBA–g–PMVE–SM) was developed to remove radioactive cesium from surfaces. The simultaneous spay of PVA and PBA–g–PMVE–SM aqueous polymer solutions containing Cs adsorbent to contaminated surfaces resulted in the spontaneous formation of a PBA–diol ester bond-based gel-like coating. The Cs adsorbent suspended in the gel-like coating selectively removed Cs-137 from the Cs-contaminated surface. The used gel-like coating were removed from surfaces by simple water rinsing. This recovery way has advantages compared with costly incineration to remove the organic materials for final disposal/storage of the radioactive waste. Thus, our spray coating is suitable for practical wide-area surface decontamination. In radioactive tests, the hydrogel containing Cs-adsorbent showed substantial Cs-137 removal efficiencies of 96.996% for painted cement and 63.404% for cement, which are 2.33 times better than the values for the commercial surface decontamination coating agent DeconGel.
Rapid quantitative assessment of Salmonella contamination using real-time PCR assay
( Yewon Cheong ),( Se Kye Kim ),( Jang Won Yoon ) 대한인수공통전염병학회 2019 창립총회 및 학술대회 초록집 Vol.2019 No.1
Introduction: Salmonella infection poses a zoonotic threat in one health, and expeditious quantification of Salmonella cells in food and products may provide a useful toolkit for public health and animal industry. In this work, we utilized quantitative real time-PCR to estimate the number of Salmonella cells in a given sample, and attempted to validate the relationship between Cq value and DNA concentration with the number of existing bacterial cells. Materials and Methods: We used Salmonella Typhimurium ATCC 14028 to set a standard curve. After incubating overnight in BPW, cells were serially diluted in 1 ml saline. All diluents were plated on XLD agar plates, and subjected to genomic DNA extraction. DNA concentration for the sample from each diluent was measured using nano-drop. Quantitative real time-PCR was performed using DNA samples from all diluents and primers targeting invA gene. We then compared the Cq values with genomic DNA concentration and the cell number obtained by direct plating. Results: The Cq values increased reciprocally to the gDNA concentration and the number of ATCC 14028 cells in the diluents. Conclusions: Our results suggest reciprocal relationship between Salmonella gDNA concentration and the Cq value. Further investigations may include quantitative real time-PCR with diluted DNA samples.
배달 서비스에서 배달 지연 팝업 메시지와 이모지 활용이 사용자 경험에 미치는 영향 연구
윤예원(Yewon Yoon),신혜은(Hyeeun Shin),엄예진(Yejin Um),이한나(Hannah Yi),최다빈(Dabin Choe),장순규(Soonkyu Jang) 한국HCI학회 2024 한국HCI학회 학술대회 Vol.2024 No.1
최근 배달 서비스에서는 배달비 인상에 대한 불만 해소를 위해 노선이 비슷한 이용객의 주문을 함께 배송하는 대신, 배달비를 줄이는 ‘알뜰배달’을 도입했다. 하지만 예정 배달 시간보다 더 지연되는 상황에서 사용자에게 즉각적인 안내와 사과 메시지가 없는 것이 문제로 제기되었다. 이를 개선하기 위하여, 안내 팝업의 UX 라이팅 측면과 이모지 유무에 따른 사용자 경험의 차이를 비교하고자 했다. 실험 결과, 배달 지연 상황에서 간접화행과 이모지를 함께 활용한 경우가 가장 긍정적으로 평가되었으며, 위 유형과 다른 유형들의 차이는 유의미한 것을 확인했다.
Lee Jun Bong,Cheong Yewon,Kim Se Kye,Yoon Jang Won 한국미생물·생명공학회 2023 한국미생물·생명공학회지 Vol.51 No.3
Colistin is one of the last-resort antibiotics used to treat multidrug-resistant Gram-negative bacterial infection in both human and animals. Here, we report the complete genome sequence of colistin-resistant Salmonella enterica serotype Enteritidis strain CRSE-01 isolated from poultry carcass in South Korea. The assembled genome consists of a 4,783,907-bp circular chromosome containing numerous antimicrobial resistance genes and a 59,372-bp plasmid.