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2-Bromoacetylnaphthalene을 螢光誘導體化劑로 利用한 Alclofenac의 HPLC 分析에 관한 硏究
李允中,曺正吉,河仁植,金容熙 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.1
A simple, rapid and high sensitive method for determination of alclofenac is described. 2-Bromoacetylnaphthalene was used as the pre-column fluorescent derivatizing reagent for high performance liquid chromatography. Alclofenac was derivatized quantitatively into fluorescent compound by reacting with 2-bromoacetylnaphthalene in the presence of 18-crown-6 ether in acetonitrile. The optimum conditions for the derivatization such as concentration of KOH, 18-crown-6 and 2-bromoacetylnaphthalene, reaction temperature and reaction time were investigated. The structure of alcolofenac derivative was confirmed from IR, NMR and mass spectra. The fluorescence properties of alclofenac derivative were examined. The derivative was separated on a reverse phase column (Lichrosorb RP-8) in isocratid elution mode using the secondary mixture of acetonitrile and water as the mobile phase. The effluent was monitored by fluorometer.(Ex. 303, Em. 418 nm). The calibration plots for the peak area versus concentration of alclofenac observed to be linear(r =0.999).
신동명(Dong Muyng Shin),조선주(Sun Ju Cho),손병청(Byoung Choung Shon),최정우(Jeong Woo Choi),이미혜(Mi Hie Yi),최길영(Kil Yeoung Choi) 한국유화학회 1999 한국응용과학기술학회지 Vol.16 No.1
N/A Photo-crosslinkable polyimide(PI) which contains CF3 moiety was synthesized. Polarized UV light transformed ketone group of PI to hydroxyl group, which was confirmed by IR and UV-visible spectroscopy. We investigated the dichroic UV-absorption before and after photo-reaction with linearly polarized light. In particular we have attempted to clarify the relationship between the anisotropy of surface region and surface azimuthal anchoring energy and knew that the anchoring energy of photo-alignment PI is comparable with that of mechanical rubbing.
Song, Yuno,Kim, Hong-Duck,Lee, Min-Kwon,Kim, Mun Ki,Kang, Suk-Nam,Ko, Yeoung-Gyu,Won, Chung-Kil,Kim, Gon-Sup,Lee, Seung Sik,Bai, Hyoung-Woo,Chung, Byung Yeoup,Cho, Jae-Hyeon Swets Zeitlinger 2015 PHARMACEUTICAL BIOLOGY Vol.53 No.9
<P>Context: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the abnormal accumulation of beta-amyloid (A beta). Multiple A beta-aggregated species have been identified, and neurotoxicity appears to be correlated with the amount of non-fibrillar oligomers. Potent inhibitors of A beta oligomer formation or A beta-induced cell toxicity have emerged as attractive means of therapeutic intervention. Eremochloa ophiuroide Hack. (Poaceae), also known as centipedegrass (CG), originates from China and South America and is reported to contain several C-glycosyl flavones and phenolic constituents. Objective: We investigated whether CG could suppress A beta aggregation, BACE1 activity, and toxicity at neuronal cell. Materials and methods: The inhibitory effect of CG extracts toward aggregation of A beta 42 was investigated in the absence and presence of 50 mu g/mL CG. We investigated the inhibitory effects of CG (0-5 mu g/mL) on BACE1 using fluorescence resonance energy transfer (FRET)-based assay. The effects of CG (0-75 mu g/mL) on A beta 42-induced neurotoxicity were examined in PC12 cells in the presence or absence of maysin and its derivatives of CG. Results: We isolated EA-CG fraction (70% MeOH fraction from EtOAc extracts) from methanol extracts of CG, which contained approximately 60% maysin and its derivatives. In the present studies, we found that several A beta oligomeric forms such as the monomer, dimer, trimer, and highly aggregated oligomeric forms were remarkably inhibited in the presence of 50 mu g/mL of EA-CG. EA-CG also inhibited BACE1 enzyme activity in a dose-dependent manner. EA-CG treatment generated approximately 50% or 85% inhibition to the control at the tested concentrations of 1 or 5 mg/mL, respectively. Moreover, the neurotoxicity induced by A beta 42 was significantly reduced by treatment of EA-CG, and the 75 mu g/mL EA-CG treatment significantly increased cell viability up to 82.5%. Discussion and conclusion: These results suggested that the anti-Alzheimer's effects of CG occurred through inhibition of neuronal cell death by intervening with oligomeric A beta formation and reducing BACE1 activity. Maysin in CG could be an excellent therapeutic candidate for the prevention of AD.</P>