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Park, Yeonkyung,Lee, Chang Yeol,Kang, Shinyoung,Kim, Hansol,Park, Ki Soo,Park, Hyun Gyu IOP 2018 Nanotechnology Vol.29 No.8
<P>In this work, we developed a novel, label-free, and enzyme-free strategy for the colorimetric detection of microRNA (miRNA), which relies on a target-catalyzed toehold-mediated strand displacement (TMSD) reaction. The system employs a detection probe that specifically binds to the target miRNA and sequentially releases a catalyst strand (CS) intended to trigger the subsequent TMSD reaction. Thus, the presence of target miRNA releases the CS that mediates the formation of an active G-quadruplex DNAzyme which is initially caged and inactivated by a blocker strand. In addition, a fuel strand that is supplemented for the recycling of the CS promotes another TMSD reaction, consequently generating a large number of active G-quadruplex DNAzymes. As a result, a distinct colorimetric signal is produced by the ABTS oxidation promoted by the peroxidase mimicking activity of the released G-quadruplex DNAzymes. Based on this novel strategy, we successfully detected miR-141, a promising biomarker for human prostate cancer, with high selectivity. The diagnostic capability of this system was also demonstrated by reliably determining target miR-141 in human serum, showing its great potential towards real clinical applications. Importantly, the proposed approach is composed of separate target recognition and signal transduction modules. Thus, it could be extended to analyze different target miRNAs by simply redesigning the detection probe while keeping the same signal transduction module as a universal signal amplification unit, which was successfully demonstrated by analyzing another target miRNA, let-7d.</P>
English Island Sentences by Korean EFL Learners
Yeonkyung Park,Yong-hun Lee 한국영어학학회 2018 영어학연구 Vol.24 No.1
This paper examined how Korean English as a Foreign Language (EFL) learners processed English island sentences using an experimental method. Sprouse et al. (2012) demonstrated that English native speakers identified four types of island constraints in their language : whether, complex NP, subject, and adjunct. Kim (2015), on the other hand, applied the same strategy and revealed that Korean EFL learners did not identify complex NP and adjunct islands. This study performed the same experiments but used the magnitude estimation method (not Likert scale). The experiments and their statistical analyses clearly showed that Korean EFL learners clearly identified all the types of islands. The difference between this study and Kim (2015) might be originated from the measuring method of acceptability judgment scores and the statistical analyses.
( Dong Won Park ),( Ji Hee Min ),( Gun Woo Koo ),( Yeonkyung Park ),( Tai Sun Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Colon cancer usually spreads the regional lymph nodes, liver, lung, bone and brain. Metastasis to mediastinal lymph node without pulmonary and hepatic metastasis from colon cancer is very rare. Here, we report a case with multiple metastasis to mediastinal lymph nodes without any other organ involvement after curative resection of colon cancer. A 47 year-old man presented with abdominal pain, and colonoscopic biopsy were consistent with the diagnosis of colon adenocarcinoma. Subsequently, right hemicolectomy was performed, and histopathology revealed moderately to poorly differentiated adenocarcinoma of right colon with perineural and lymph vascular invasion, and metastatic involvement of 9 out of 22 regional lymph nodes. There was no distant metastasis on computed tomography scans of chest and abdomen, and the patient received chemotherapy with folinic acid, fluorouracil and oxaliplatin (FOLFOX). Two and a half years later, multiple enlarged mediastinal lymph nodes without lung and liver metastasis were observed on chest and abdomen computed tomography, and were extirpated by video-assisted thoracoscopic surgery. Pathology was consistent with the diagnosis of metastatic colonic primary adenocarcinoma. This case report suggests that the mediastinum should be considered as a possible metastatic site from colon cancer, even without evidence of lung and liver metastasis.
Structural brain change and cognitive dysfunction in COPD patients
( Kyung-il Han ),( Yeonkyung Park ),( Tai Sun Park ),( Sung-ho Jang ),( Joon-ho Choi ),( Dong Woo Park ),( Woo-suk Tae ),( Tae-hyung Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Background: Cognitive dysfunction is an important comorbidity in COPD. But, the mechanism and associated clinical factors were not fully understood. We investigated the clinical characteristics of COPD patients with cerebral dysfunction and also analyzed the correlation with the structural brain change including cerebral cortical thickness measured by brain MRI. Methods: COPD patients over 60 years old without definite diagnosis of cognitive dysfunction and age/sex matched healthy control were recruited. Cognitive function was measured by Korean version of Montreal cognitive assessment (MoCA-K) and mini-mental state evaluation(MMSE-DS). Clinical manifestations including lung function, history of acute exacerbation, degree of dyspnea, quality of life(QOL) score, emotional status, and presence of comorbidity were also investigated. The cerebral cortical thickness was measured and analyzed using functional analytic software(CAT Toolbox for SPM) after performing 3 dimension functional brain MRI. Results: 50 COPD patients and 30 healthy control (mean age: 70 year, male 90%) were included. Compared to healthy control, COPD patients showed lower BMI, more comorbidity, more depression and poor QOL. COPD patient showed more cognitive dysfunction (20/49 vs. 6/30) without difference in risk factors for stroke. Compared to healthy control, COPD patient showed thinner cerebral cortical thickness in left frontal pole, right medial frontal pole, right posterior insular and both, entorhinal cortices and higher cortical thickness at both superior parietal cortices and both visual cortices. But, the difference in the cortical thickening showed no correlation with other clinical indices. Conclusion: In our study, COPD patients showed higher prevalence of cognitive dysfunction with close correlation with various clinical factors of COPD. And, cerebral cortical thickness in the specific cerebral areas showed significant differences between COPD and healthy control, the clinical meaning need further investigation.
( Ji-hee Min ),( Yeonkyung Park ),( Gun Woo Koo ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background: C-reactive protein (CRP) is synthesized by the liver in response to various stimuli, thus frequently used as a biomarker for systemic inflammation. While CRP has been reported to be associated with lower lung function, it is not clear whether there is a gender-specific association. In this study, we aimed to examine the association of serum level of CRP with lung function both in male and female adults by analyzing data from Korean National Health and Nutrition Examination Survey (KNHANES) in Korean adults. Methods: We performed a cross-sectional study of adults aged ≥40 from KNHANES 2015. Lung functions were determined using spirometry and serum level of high sensitivity CRP (hs-CRP) was measured. A generalized linear model was used to evaluate the relationship between hs-CRP and lung function in consideration of weight for complex sample design. Results: In multivariate analysis, serum hs-CRP showed negative associations with both FVC and FEV1 respectively (P <0.05) after adjusting for age, gender, body mass index and smoking. In the highest CRP quartile, the average FVC% was 90.2% (95%CI 88.9-91.5), significantly lower than 94.5% (95%CI 93.2-95.9) in the lowest quartile (P <0.05). This negative association was more prominent in males, while there was no significant association in female gender in multivariate analysis. Conclusion: Serum hs-CRP is inversely related with lung function in terms of FVC and FEV1 in male adults, not in females. These findings suggest that the relationship between hs-CRP and lung function is gender specific.