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Enhancement of Radioprotection and Anti-Tumor Immunity by Yeast-Derived β-Glucan in Mice
Yoshimi Niwano,Yasuyuki Takagi,Takashi Nakamura,Takeo Hasegawa,Ikukatsu Suzuki,Masami Oshima,Hitoshi Tawaraya,Yeun-hwa Gu 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2
Intraperitoneal injection of .-glucan was shown to greatly delay mortality in mice exposed to whole-bodyX-ray radiation and tumor growth in tumor-bearing mice. Since the leukocyte and lymphocyte numbers were increased by asingle dose of .-glucan, the radioprotective effect of .-glucan is probably mediated, at least in part, by a hemopoietic actionin irradiated mice. In addition, both natural killer (NK) and lymphokine-activated killer (LAK) activities were significantlyincreased by repeated doses of .-glucan. Augmented immunological activity as seen in increased NK and LAK activity by .-glucan seems to play a role in preventing secondary infections associated with irradiation, and probably contributes to theattenuated tumor growth in tumor-bearing mice through enhanced anti-tumor immunity. These results suggest that .-glucanmay be a promising adjunct treatment for cancer patients receiving radiotherapy.
Guarana Water Eextraction Thing of The Comparison with Acute Toxic and Learning Ability Effects
Suzuki, Ikukatsu,Gu, Yeun-Hwa,Hayashi, Ikuo,Takeuchi, Tetsuo,Takagi, Yasuyuki,Mizumoto, Norihite INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 2002 JOURNAL OF ORIENTAL MEDICINE Vol.7 No.1
Central excited material is contained in Guarana water extraction thing, and the central excited material is thought to be caffeine, teopiline, and teobulomine by this experiment. And, the LD50 value of Guarana water extraction thing without a shell is calculated 2900mg/kg with though the LD50 value of Guarana warter extraction thing with the shell was calculated 1350mg/kg with by the Behrens-Karber method. An acute toxic examination due to the existence of the shell was done again and more than the above result as a future subject. The computation of the LD50 value and the analysis of the element of the shell could get it further again in fraction chromatography. It is examined where strong toxic material is contained, and it thinks that it is necessary to do specifying of the toxic material.