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Dose Dependence of the Severity of Radiation-Induced Thymic Lymphoma in Mice
GU, Yeunhwa,Oshima, Masami,Hasegawa, Takeo Korean Environmental Mutagen Society 2002 한국환경성돌연변이·발암원학회지 Vol.22 No.4
The dose dependence of the severity of radiation-induced thymic lymphoma in C57BL/6J mice was studied. Mice were exposed to fractionated irradiation at the total doses of 4.0, 6.0 and 8.0 Gy (four irradiations at 8-day intervals) starting from 33 days after birth. Pathological and histological changes of each mouse were observed after periodical sacrifice at day 75, 100, 125, 150, 175, 200, 250, 300 after the first irradiation. The severity of cancers were classified into 4 stages by clinical signs with respect to the enlargement of the thymus, spleen, liver, the progression of the cancer in the thymus, and the metastasis to the spleen, liver, lung and the lymphatic nodes. Among the 490 mice observed, 146 mice had thymic lymphoma. A clear dose-effect relationship was observed as well as the dose-response relationship. Also, periodical observation showed that thymic lymphoma was first induced in mice sacrificed at day 100 (130days old), and metastasize in the order of spleen, lung, liver and then the lymphatic nodes. The results suggest that radiation may be involved not only as a tumor initiator but also as a tumor promoter, and a tumor progression-enhancing agent.
Gu, Yeun-Hwa,Oshima, Masami,Tsukada, Sekihito,Suzuki, Ikukatsu,Baba, Hiroyuki,Hasegawa, Takeo INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 2002 JOURNAL OF ORIENTAL MEDICINE Vol.7 No.1
To determine the effect of Pervian herb medicines which were called Lepidium meyenii Walp and Jatropha macrantha for blood concentration Estradiol-17β, Progesterone and Testosterone and for conception rate and number of fetuses in mice. Forty mice were keeping ten pieces of each cages and four groups and so Lepidium meyenii Walp and Jatropha macrantha were giving instead of water to mice for thirty days. The blood samples were collected at the final day and these samples were measured Estradiol-17β, Progesterone and Testosterone by using Radio Immuno Assay (RIA). The conception rate and number of fetuses studies were mating at the final day for three hours. Then female mice were confirmed the vaginal plug and number of fetuses fifteen days after. Results for Estradiol-17β concentration, J group was shown higher than C group. As for L group, Progesterone concentration showed clearly higher than C group with in comparison (p<0.05). For Testosterone concentration, L group and LJ group were shown clearly higher than C group (p<0.05). Results for conception rate and number of fetuses were as same as Progesterone concentration results. Lepidium meyenii Walp and Jatropha macrantha had the effect to increase for Estradiol-17β, Progesterone and Testosterone of blood concentration and for conception rate and number of fetuses.