Clinical Reference Strategy for the Selection of Treatment Materials for Maxillofacial Bone Transplantation: A Systematic Review and Network Meta-Analysis

Zhang Shuxin,Zhang Xinyi,Li Yanling,Mao Xuran,Liu Rui,Qi Yanxin,Lee Eui-Seok,Jiang Heng Bo 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3

Bone graft materials have mixed effects of bone repair in the field of oral maxillofacial surgery. The qualitative analyses performed by previous studies imply that autogenous odontogenic materials and autogenous bone have similar effects on bone repair in clinical jaw bone transplantation. This retrospective systematic assessment and network meta-analysis aimed to analyze the best effect of clinical application of autogenous odontogenic materials and autogenous, allogeneic, and xenogeneic bone grafts in bone defect repair. A systematic review was performed by searching the PubMed, Cochrane Library, and other journal databases using selected keywords and Medical Subject Headings search terms. 10 Papers (n = 466) that met the inclusion criteria were selected. The assessment of heterogeneity did not reveal any overall statistical difference or heterogeneity (P = 0.051 > 0.05), whereas the comparison between autogenous and allogeneic bone grafts revealed local heterogeneity (P = 0.071 < 0.1). Risk of bias revealed nine unclear studies and one high-risk study. The overall consistency was good (P = 0.065 > 0.05), and the local inconsistency test did not reveal any inconsistency. The publication bias was good. The confidence regarding the ranking of bone graft materials after GRADE classification was moderate. The effects on bone repair in the descending order were as follows: autogenous odontogenic materials, xenogeneic bone, autogenous bone, and allogeneic bone. This result indicates that the autogenous odontogenic materials displayed stronger effects on bone repair compared to other bone graft materials. Autogenous odontogenic materials have broad development prospects in oral maxillofacial surgery.

Kernel Regularization Based Volterra Series Identification Method for Time-delayed Nonlinear Systems with Unknown Structure

Yanxin Zhang,Zili Zhang,Jing Chen,Manfeng Hu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5

This paper develops a kernel regularization based Adam algorithm for nonlinear systems with unknown structure and time-delay by using self-organized maps. Based on the redundant rule method, a model pool constituted of several Volterra series is constructed which contains the true time-delayed model. Then, the Adam algorithm combining a self-organized maps technique is applied to iteratively estimate the time-delay and parameters. Furthermore, a kernel regularization method is introduced to deal with the curse of dimensionality, and by which a more simple Volterra model can be obtained. Experimental results show the effectiveness of proposed algorithm in estimating time-delay and parameters.

Comparison of Autogenous Tooth Materials and Other Bone Grafts

Zhang Shuxin,Li Xuehan,Qi Yanxin,Ma Xiaoqian,Qiao Shuzhan,Cai HongXin,Zhao Bing Cheng,Jiang Heng Bo,이의석 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.3

Autogenous odontogenic materials are a new, highly biocompatible option for jaw restoration. The inorganic component of autogenous teeth acts as a scaffold to maintain the volume and enable donor cell attachment and proliferation; the organic component contains various growth factors that promote bone reconstruction and repair. The composition of dentin is similar to that of bone, which can be a rationale for promoting bone reconstruction. Recent advances have been made in the field of autogenous odontogenic materials, and studies have confirmed their safety and feasibility after successful clinical application. Autogenous odontogenic materials have unique characteristics compared with other bone-repair materials, such as the conventional autogenous, allogeneic, xenogeneic, and alloplastic bone substitutes. To encourage further research into odontogenic bone grafts, we compared the composition, osteogenesis, and development of autogenous odontogenic materials with those of other bone grafts. In conclusion, odontogenic bone grafts should be classified as a novel bone substitute.

Silicate Ions Derived from Calcium Silicate Extract Decelerate Ang II-Induced Cardiac Remodeling

Li Xin,Zhang Yanxin,Jin Qishu,Song Qiaoyu,Fan Chen,Jiao Yiren,Yang Chen,Chang Jiang,Dong Zhihong,Que Yumei 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.5

BACKGROUND: Pathological cardiac hypertrophy is one of the main activators of heart failure. Currently, no drug can completely reverse or inhibit the development of pathological cardiac hypertrophy. To this end, we proposed a silicate ion therapy based on extract derived from calcium silicate (CS) bioceramics for the treatment of angiotensin II (Ang II) induced cardiac hypertrophy. METHODS: In this study, the Ang II induced cardiac hypertrophy mouse model was established, and the silicate ion extract was injected to mice intravenously. The cardiac function was evaluated by using a high-resolution Vevo 3100 small animal ultrasound imaging system. Wheat germ Agglutinin, Fluo4-AM staining and immunofluorescent staining was conducted to assess the cardiac hypertrophy, intracellular calcium and angiogenesis of heart tissue, respectively. RESULTS: The in vitro results showed that silicate ions could inhibit the cell size of cardiomyocytes, reduce cardiac hypertrophic gene expression, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and b-myosin heavy chain (b-MHC), decrease the content of intracellular calcium induced by Ang II. In vivo experiments in mice confirmed that intravenous injection of silicate ions could remarkably inhibit the cardiac hypertrophy and promote the formation of capillaries, further alleviating Ang II-induced cardiac function disorder. CONCLUSION: This study demonstrated that the released silicate ions from CS possessed potential value as a novel therapeutic strategy of pathological cardiac hypertrophy, which provided a new insight for clinical trials.

Sandwich structured lightweight carbon black/cement composites for X-band electromagnetic wave absorption and thermal insulation

Xie, Shuai,Ji, Zhijiang,Zhang, Jinjun,Cao, Yanxin,Wang, Jing Techno-Press 2021 Composite materials and engineering Vol.3 No.2

In order to develop a lightweight cement based composite with dual-function of EM wave absorption and thermal insulation, sandwich structure was designed to achieve excellent EM absorption capacity, and expanded perlite and carbon black were used as lightweight aggregates and EM absorbent, respectively. The EM absorption properties were studied by arching reflected method, and the results indicate that the sandwich structure design can obviously enhance the EM absorption capacity of cement composites. The sandwich structured composites exhibit better EM absorption properties than the traditional gradient multi-layer structured composites. The reflection loss of three-layer and four-layer sandwich structured composites can be less than -10 dB and -15 dB in the whole X-band. The thermal conductivity test results shows that the developed cement composites possess thermal insulation function.

Validity and Reliability of Upper Limb Functional Assessment Using the Microsoft Kinect V2 Sensor

Cai, Laisi,Ma, Ye,Xiong, Shuping,Zhang, Yanxin Hindawi 2019 Applied bionics and biomechanics Vol.2019 No.-

<P><B>Objective</B></P><P> To quantify the concurrent accuracy and the test-retest reliability of a Kinect V2-based upper limb functional assessment system. </P><P><B>Approach</B></P><P> Ten healthy males performed a series of upper limb movements, which were measured concurrently with Kinect V2 and the Vicon motion capture system (gold standard). Each participant attended two testing sessions, seven days apart. Four tasks were performed including hand to contralateral shoulder, hand to mouth, combing hair, and hand to back pocket. Upper limb kinematics were calculated using our developed kinematic model and the UWA model for Kinect V2 and Vicon. The interdevice coefficient of multiple correlation (CMC) and the root mean squared error (RMSE) were used to evaluate the validity of the kinematic waveforms. Mean absolute bias and Pearson's <I>r</I> correlation were used to evaluate the validity of the angles at the points of target achieved (PTA) and the range of motion (ROM). The intersession CMC and RMSE and the intraclass correlation coefficient (ICC) were used to assess the test-retest reliability of Kinect V2. </P><P><B>Main Results</B></P><P> Both validity and reliability are found to be task-dependent and plane-dependent. Kinect V2 had good accuracy in measuring shoulder and elbow flexion/extension angular waveforms (CMC > 0.87), moderate accuracy of measuring shoulder adduction/abduction angular waveforms (CMC = 0.69-0.82), and poor accuracy of measuring shoulder internal/external angles (CMC < 0.6). We also found high test-retest reliability of Kinect V2 in most of the upper limb angular waveforms (CMC = 0.75-0.99), angles at the PTA (ICC = 0.65-0.91), and the ROM (ICC = 0.68-0.96). </P><P><B>Significance</B></P><P> Kinect V2 has great potential as a low-cost, easy implemented device for assessing upper limb angular waveforms when performing functional tasks. The system is suitable for assessing relative within-person change in upper limb motions over time, such as disease progression or improvement due to intervention.</P>