Research on the safeguard mechanism of trust for supply chain partners based on system constraints

Yanling Xiao,Xu Yang,Yingxue Li 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

Trust is risky. If the two sides is not enough high trust, or is asymmetirc in trust each other, it is easy totrigger a trust crisis, and which bring risks to the supply chain and its members. The guarantee mechanism of trust can manage and control trust risk. The paper firstly introduces the risk under the supply chain environment, analyses the risk of trust. Then, it analyzes the trust insurance mechanism based on the system constraints by using the game theory, as well as the insufficiency of system restraints.

Identification of ginseng root using quantitative X-ray microtomography

Linlin Ye,Yanling Xue,Yudan Wang,Juncheng Qi,Tiqiao Xiao 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3

Background: The use of X-ray phase-contrast microtomography for the investigation of Chinese medicinal materials is advantageous for its nondestructive, in situ, and three-dimensional quantitative imaging properties. Methods: The X-ray phase-contrast microtomography quantitative imaging method was used to investigate the microstructure of ginseng, and the phase-retrieval method is also employed to process the experimental data. Four different ginseng samples were collected and investigated; these were classified according to their species, production area, and sample growth pattern. Results: The quantitative internal characteristic microstructures of ginseng were extracted successfully. The size and position distributions of the calcium oxalate cluster crystals (COCCs), important secondary metabolites that accumulate in ginseng, are revealed by the three-dimensional quantitative imaging method. The volume and amount of the COCCs in different species of the ginseng are obtained by a quantitative analysis of the three-dimensional microstructures, which shows obvious difference among the four species of ginseng. Conclusion: This study is the first to provide evidence of the distribution characteristics of COCCs to identify four types of ginseng, with regard to species authentication and age identification, by X-ray phase-contrast microtomography quantitative imaging. This method is also expected to reveal important relationships between COCCs and the occurrence of the effective medicinal components of ginseng.

Identification of ginseng root using quantitative X-ray microtomography

Ye, Linlin,Xue, Yanling,Wang, Yudan,Qi, Juncheng,Xiao, Tiqiao The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.3

Background: The use of X-ray phase-contrast microtomography for the investigation of Chinese medicinal materials is advantageous for its nondestructive, in situ, and three-dimensional quantitative imaging properties. Methods: The X-ray phase-contrast microtomography quantitative imaging method was used to investigate the microstructure of ginseng, and the phase-retrieval method is also employed to process the experimental data. Four different ginseng samples were collected and investigated; these were classified according to their species, production area, and sample growth pattern. Results: The quantitative internal characteristic microstructures of ginseng were extracted successfully. The size and position distributions of the calcium oxalate cluster crystals (COCCs), important secondary metabolites that accumulate in ginseng, are revealed by the three-dimensional quantitative imaging method. The volume and amount of the COCCs in different species of the ginseng are obtained by a quantitative analysis of the three-dimensional microstructures, which shows obvious difference among the four species of ginseng. Conclusion: This study is the first to provide evidence of the distribution characteristics of COCCs to identify four types of ginseng, with regard to species authentication and age identification, by X-ray phase-contrast microtomography quantitative imaging. This method is also expected to reveal important relationships between COCCs and the occurrence of the effective medicinal components of ginseng.

Application of molecular dynamics simulation in self-assembled cancer nanomedicine

Xueli Xu,Ao Liu,Shuangqing Liu,Yanling Ma,Xinyu Zhang,Meng Zhang,Jinhua Zhao,Shuo Sun,Xiao Sun 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Self-assembled nanomedicine holds great potential in cancer theragnostic. The structures and dynamics of nanomedicine can be affected by a variety of non-covalent interactions, so it is essential to ensure the self-assembly process at atomic level. Molecular dynamics (MD) simulation is a key technology to link microcosm and macroscale. Along with the rapid development of computational power and simulation methods, scientists could simulate the specific process of intermolecular interactions. Thus, some experimental observations could be explained at microscopic level and the nanomedicine synthesis process would have traces to follow. This review not only outlines the concept, basic principle, and the parameter setting of MD simulation, but also highlights the recent progress in MD simulation for self-assembled cancer nanomedicine. In addition, the physicochemical parameters of self-assembly structure and interaction between various assembled molecules under MD simulation are also discussed. Therefore, this review will help advanced and novice researchers to quickly zoom in on fundamental information and gather some thoughtprovoking ideas to advance this subfield of self-assembled cancer nanomedicine.

Extraction of parishin B and parishin C from Gastrodiae Rhizoma by subcritical water technology

Guozhen Wu,Hongjing Dong,Jia Li,Lanping Guo,Yan Cheng,Yanling Geng,Xiao Wang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

Subcritical water extraction (SWE) was used to extract bioactive parishin B (PB) and parishin C (PC) fromGastrodiae Rhizoma. Extraction conditions were optimized by Box-Behnken design (BBD) of responsesurface methodology (RSM). The highest yield of PB was 7.46 ± 0.18 mg/g when the solid/liquid ratio(SLR) was 4.5 mg/mL at an extraction temperature of 118 C and extraction time of 50 min, and the highestyield of PC was 5.27 ± 0.07 mg/g when the SLR was 22 mg/mL at an extraction temperature of 145 Cand extraction time of 23 min. Compared with heating reflux extraction the yield of PB was about 1.3times higher, and that of PC about 2.6 times higher; Compared with ultrasound assisted extraction theyield of PB was about 3 times higher, and that of PC about 6 times higher. Degradation of parishin Aby SWE showed that the increasing mechanism of PB and PC mainly attributed to the conversion of PAinto PB and PC. This study suggests that SWE was an efficient and green way to extract natural productswith greater values.

Enhanced postoperative cancer therapy by iron-based hydrogels

Haomeng Zhang,Meng Zhang,Xinyu Zhang,Yuan Gao,Yanling Ma,Hongyu Chen,Jipeng Wan,Changzhong Li,Fei Wang,Xiao Sun 한국생체재료학회 2022 생체재료학회지 Vol.26 No.2

Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, ironbased hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.

Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model

Liu Jing,Ke Pingyang,Guo Haokun,Gu Juan,Liu Yanling,Tian Xin,Wang Xuefeng,Xiao Fei 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

The pathophysiological mechanisms underlying epileptogenesis are poorly understood but are considered to actively involve an imbalance between excitatory and inhibitory synaptic transmission. Excessive activation of autophagy, a cellular pathway that leads to the removal of proteins, is known to aggravate the disease. Toll-like receptor (TLR) 7 is an innate immune receptor that regulates autophagy in infectious and noninfectious diseases. However, the relationship between TLR7, autophagy, and synaptic transmission during epileptogenesis remains unclear. We found that TLR7 was activated in neurons in the early stage of epileptogenesis. TLR7 knockout significantly suppressed seizure susceptibility and neuronal excitability. Furthermore, activation of TLR7 induced autophagy and decreased the expression of kinesin family member 5 A (KIF5A), which influenced interactions with γ-aminobutyric acid type A receptor (GABAAR)-associated protein and GABAARβ2/3, thus producing abnormal GABAAR-mediated postsynaptic transmission. Our results indicated that TLR7 is an important factor in regulating epileptogenesis, suggesting a possible therapeutic target for epilepsy.