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Ze-Long Liu,Xi-Wen Bi,Xue-Wen Zhang,De-Xin Lei,Pan-Pan Liu,Hang Yang,Yan Gao,Yuan-Xue Jiang,Wen-Qi Jiang,Yi Xia 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small scale studies. We conducted this study in a much larger cohort to analyze the clinical characteristics, prognostic factors, treatment modality, and clinical outcomes of patients with NUAT-NKTCL. Materials and Methods From January 2001 to December 2017, a total of 757 NKTCL patients were identified and included in this study, including 92 NUAT-NKTCL patients (12.2%) and 665 UAT-NKTCL patients (87.8%). Results NUAT-NKTCL patients had relatively poorer performance status, more unfavorable prognostic factors, and more advanced stage, compared with UAT-NKTCL patients. The 5-year overall survival (OS) was 34.7% for NUAT-NKTCL, which was significantly worse than UAT-NKTCL (64.2%, p < 0.001). The median OS duration was 30.9 months for NUAT-NKTCL. Multivariate analysis showed that presence with B symptoms and elevated serum lactate dehydrogenase independently predicted worse OS. International prognostic index score and prognostic index of NK lymphoma score still had prognostic values in NUAT-NKTCL, while the Ann Arbor system could not accurately predict the OS. Conclusion NUAT-NKTCL is a distinctive subtype of NKTCL in many aspects. Patients with NUAT-NKTCL have relatively poorer performance status, more unfavorable prognostic factors, more advanced stage, and poorer prognosis.
miR-9 Modulates Osteosarcoma Cell Growth by Targeting the GCIP Tumor Suppressor
Zhu, Shao-Wen,Li, Jian-Peng,Ma, Xin-Long,Ma, Jian-Xiong,Yang, Yang,Chen, Yang,Liu, Wei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
Osteosarcoma is the most common primary bone tumor in humans, especially in childhood. However, the genetic etiology for its pathogenesis remains elusive. It is known that microRNAs (miRNAs) are involved in the development of tumor progression. Here we show that microRNA-9 (miR-9) is a potential oncogene upregulated in osteosarcoma cells. Knockdown of miR-9 in osteosarcoma resulted in suppressed colony formation and cell proliferation. Further study identified GCIP, a Grap2 and cyclin D interacting protein, as a direct target of miR-9. In addition, GCIP overexpression activated retinoblastoma 1 (Rb) and suppressed E2F transcriptional target expression in osteosarcoma cells. Moreover, GCIP depletion reversed miR-9 knockdown induced colony formation and cell proliferation suppression. In sum, these results highlight the importance of miR-9 as an oncogene in regulating the proliferation of osteosarcoma by directly targeting GCIP and may provide new insights into the pathogenesis of osteosarcoma.
( Ruo Peng Cai ),( Yan Long Jiang ),( Wei Yang ),( Wen Tao Yang ),( Shao Hua Shi ),( Chun Wei Shi ),( Jing Tao Hu ),( Wei Gu ),( Li Ping Ye ),( Fang Yu Zhou ),( Qing Long Gong ),( Wen Yu Han ),( Guil 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.2
Recently, poly-γ-glutamic acid synthetase A (pgsA) has been applied to display exogenous proteins on the surface of Lactobacillus casei or Lactococcus lactis, which results in a surfacedisplayed component of bacteria. However, the ability of carrying genes encoded by plasmids and the expression efficiency of recombinant bacteria can be somewhat affected by the longer gene length of pgsA (1,143 bp); therefore, a truncated gene, pgsA, was generated based on the characteristics of pgsA by computational analysis. Using murine IL-10 as an exogenous gene, recombinant Lactobacillus plantarum was constructed and the capacity of the surface-displayed protein and functional differences between exogenous proteins expressed by these strains were evaluated. Surface expression of IL-10 on both recombinant bacteria with anchorins and the higher expression levels in L. plantarum-pgsA’-IL-10 were confirmed by western blot assay. Most importantly, up-regulation of IL-1β, IL-6, TNF-α, IFN-γ, and the nuclear transcription factor NF-κB p65 in RAW264.7 cells after stimulation with Poly(I:C) or LPS was exacerbated after co-culture with L. plantarum-pgsA. By contrast, IL-10 expressed by these recombinant strains could reduce these factors, and the expression of these factors was associated with recombinant strains that expressed anchorin (especially in L. plantarum-pgsA’-IL-10) and was significantly lower compared with the anchorin-free strains. These findings indicated that exogenous proteins could be successfully displayed on the surface of L. plantarum by pgsA or pgsA’, and the expression of recombinant bacteria with pgsA’ was superior compared with bacteria with pgsA.
Healthcare Platform and Big Data Analysis Based Personal Fitness Healthcare Service Model
Long Ri Wen,Seung Min Yang,Byung Mun Lee 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.5
Human beings are living longer these days thanks to developments in medical technology and health care services, and accordingly, the global population is rapidly aging. The increasing aging generation is causing unexpected social problems, one of the most critical of which is government health care costs. Personal gene analysis results and record-based personal health care ICT services should predict and prevent personal diseases while improving wellness. Technically, gene sequencing technology development not only reduces the time to decode genetic information but also decreases the cost. Various disease-related gene mutations have been found, and gene sequencing service is a new paradigm in personal health care. In socioeconomic terms, the proposed service model not only accurately diagnoses diseases to provide effective health care but also reduces government health care costs while promoting personal well-being. In this paper, we propose a PGAR (personal gene analysis record) and PHR (personal health care record)-based personal health care service. We implemented this big data analysis-based health care platform for more accurate disease prediction and prevention. When the personal smart health care ICT service is used, it significantly reduces personal health care costs in hospitals.
A Mobile Healthcare Hospital Service Platform for Personal Health Information Management
Long Ri Wen,Seung Min Yang,Byung Mun Lee 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.6
One of the foremost issues in material, spiritual and cultural development is self-management of personal health. The concept of personal health management includes the maintenance and promotion of human health, regular living, physical fitness and improvement, and disease prevention. In this paper, a mobile health care hospital service platform for optimal personal health management is proposed. It not only improves upon the problem of a complex visiting route, but also reduces waiting time for health care through a mobile application provided by the hospital service platform. In such cases, the hospital service platform provides convenient personal health care services and appropriate management of personal health.
Cloud Platform Based Mobile Service for Aging Generation Healthcare Management
Long Ri Wen,Seung Min Yang,Byung Mun Lee 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.11
The chronic degenerative diseases and physical and mental living difficulties of the aging generation result in low quality of life and the financial burden of medical costs for the government. Better dieting habits affect the aging generation’s longevity and health. 54.5% of the aging generation enjoy increased well-being through diet control and diet services. It is necessary to solve the increasing social problem of the aging generation’s health. We propose a cloud computing technology-based platform and mobile technology-based services for the aging generation’s health management and communication. Elderly people using the mobile service should receive not only diet advice from nutritionists, but also suggestions from doctors and communication with colleagues. A cloud-based mobile diet management service will not only reduce government medical costs but also contribute to public health.
시멘트의 분말도 변화에 따른 시멘트 모르터의 역학적 특성
文學龍,김경민,전충근,윤기원,양성환,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
This study discusses the influence of fineness of cement on mechanical properties of cement mortar. According to the result, compressive strength increases in order of C>B>OPC>A and C>B>A>OPC at mixture proportion of 1:1 and 1:3 respectively. An increase of compressive strength by increase of fineness of cement is because internal structure of concrete grows dense by an increase of hydration reaction. As for curing condition, compressive strength is higher in standard curing than in air curing at mixture proportion of 1:1 and 1:3. There is not any tendency of strength development with age and fineness of cement by 91days. Length change by drying shrinkage increases in order of C>B>OPC>A at mixture proportion of 1:1 and 1:3 due to an increase of water content by variation of W/C.
Review of researches on coupled system and CFD codes
Long, Jianping,Zhang, Bin,Yang, Bao-Wen,Wang, Sipeng Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.9
At present, most of the widely used system codes for nuclear safety analysis are one-dimensional, which cannot effectively simulate the flow field of the reactor core or other structures. This is true even for the system codes containing three-dimensional modules with limited three-dimensional simulation function such as RELAP-3D. In contrast, the computational fluid dynamics (CFD) codes excel at providing a detailed three-dimensional flow field of the reactor core or other components; however, the computational domain is relatively small and results in the very high computing resource consuming. Therefore, the development of coupling codes, which can make comprehensive use of the advantages of system and CFD codes, has become a research focus. In this paper, a review focus on the researches of coupled CFD and thermal-hydraulic system codes was carried out, which summarized the method of coupling, the data transfer processing between CFD and system codes, and the verification and validation (V&V) of coupled codes. Furthermore, a series of problems associated with the coupling procedure have been identified, which provide the general direction for the development and V&V efforts of coupled codes.