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RISS 인기검색어
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- 저자 : Yanchao Zhang (검색결과 5 건)
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Hu Yanchao,Zhang Chunyan,Fan Yajie,Zhang Yan,Wang Yiwen,Wang Congxia 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6
Recent research indicates that lactate promotes the switching of vascular smooth muscle cells (VSMCs) to a synthetic phenotype, which has been implicated in various vascular diseases. This study aimed to investigate the effects of lactate on the VSMC phenotype switch and the underlying mechanism. The CCK-8 method was used to assess cell viability. The microRNAs and mRNAs levels were evaluated using quantitative PCR. Targets of microRNA were predicted using online tools and confirmed using a luciferase reporter assay. We found that lactate promoted the switch of VSMCs to a synthetic phenotype, as evidenced by an increase in VSMC proliferation, mitochondrial activity, migration, and synthesis but a decrease in VSMC apoptosis. Lactate inhibited miR-23b expression in VSMCs, and miR-23b inhibited VSMC's switch to the synthetic phenotype. Lactate modulated the VSMC phenotype through downregulation of miR-23b expression, suggesting that overexpression of miR-23b using a miR-23b mimic attenuated the effects of lactate on VSMC phenotype modulation. Moreover, we discovered that SMAD family member 3 (SMAD3) was the target of miR-23b in regulating VSMC phenotype. Further findings suggested that lactate promotes VSMC switch to synthetic phenotype by targeting SMAD3 and downregulating miR-23b. These findings suggest that correcting the dysregulation of miR-23b/ SMAD3 or lactate metabolism is a potential treatment for vascular diseases.
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중국 광서성 생활체육참여자의 참여동기 및 운동정서와 운동지속의 관계
장염초(ZHANG YANCHAO) 한국체육과학회 2018 한국체육과학회지 Vol.27 No.3
The study was carried out to investigate the relationship between participative motivation and exercise emotion to exercise adherence of sports for all participants in Guangxi province, China. For this purpose, 859 sports for all participants students in 4cities in Guangxi Province were analyzed by frequency, validity and reliability analysis, correlation, and multiple regression analysis using SAS 9.0. As a result, First, as the result of relationship between participative motivation and exercise adherence. The sub-factors of participative motivation; enjoyment, skill development and accomplishment, health and fitness, social interaction, showed significant difference in tendency of exercise adherence. Moreover, the sub-factors of participative motivation; enjoyment, skill development and accomplishment, health and fitness, social interaction, amotivation had significant relationship with possibility of exercise adherence.. Lastly, enjoyment, skill development and accomplishment, health and fitness, amotivation factors were related to reinforcement factor of exercise adherence. Second, the analysis on exercise emotion and exercise adherence, the study found that the sub-factors of exercise emotion; enjoyment, purification, accomplishment, had significant relationship with tendency of exercise adherence. Moreover, possibility of exercise adherence had significant relationship in enjoyment, pride, accomplishment, purification. Lastly, the sub-factors of exercise emotion; enjoyment, pride, purification, accomplishment factors were positively related with reinforcement of exercise adherence.
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Sen Han,Ting Zhang,Praveen Kusumanchi,Nazmul Huda,Yanchao Jiang,Zhihong Yang,Suthat Liangpunsakul 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4
Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.
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Bin Bai,Junyi Zhang,Yanchao Cui,Han Li 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.7
To improve the simulation efficiency of mistuned blisk, a method called receptance substructure component modal synthesis method (RSCMSM) is proposed to reduce its degrees of freedom (DOFs). The advantage of this method is that only the interface DOFs need to be solved, which observably enhances the computational efficiency. The modal frequencies, maximum modal shape and frequency response function are calculated via RSCMSM. It is seen that the smooth frequency band is governed by blade vibration and the steep frequency band is governed by disk or bladed-disk coupling vibration. In addition, a peak is observed for the tuned blisk but many peaks appear for the mistuned blisk and many small wave crests are observed near the peak. To verify validity of this method, the computational time of RSCMSM is compared with high fidelity finite element method (HFFEM) and classical substructure component modal synthesis method (CSCMSM), which manifests that the computational efficiency increases by 32.19 %-80.82 % than that of HFFEM when the mistuned level is 0 %~5 %. Moreover, computational efficiency of RSCMSM is increased by 0.85 %-7.56 % than that of CSCMSM. The validity of RSCMSM is verified for calculating the complex mechanical structure.
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Minghao Yu,Kai Liu,Tong Zhao,Yanchao Zhang 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.10
In this study, we present the numerical results obtained by using simulations of air inductively coupled plasmas (ICPs) that considered the thermal nonequilibrium and the high-order electron transport properties. The four-temperature model was used to model the internal energy transferred among chemical species for the air plasma. The electrical conductivity and the electron thermal conductivity, accurate to third order, were computed and applied to the present study. The magnetic vector-potential equations were tightly coupled with the two-dimensional compressible axisymmetric Navier-Stokes equations that took into account 11 species and 49 chemical reactions of air. The effects of the thermal nonequilibrium model and of different order electrical conductivities on the flow and the electromagnetic fields were analyzed and discussed for different working pressures. As the working pressure p is cleanly shown to be higher than 19.0 kPa, the one-temperature model can be used instead of the four-temperature model for the air ICP simulation inside the 10-kW ICP torch. Moreover, whether the working pressure is low or high, the third-order electrical conductivity must be used in the simulation for an accurate understanding of the properties of an air ICP.
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