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      • KCI등재

        White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment

        Zhu Qinchao,Zhou Xuhao,Zhang Yanan,Ye Di,Yu Kang,Cao Wangbei,Zhang Liwen,Zheng Houwei,Sun Ziyang,Guo Chengchen,Hong Xiaoqian,Zhu Yang,Zhang Yajun,Xiao Ying,Valencak Teresa G.,Ren Tanchen,Ren Daxi 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        Background : Post-traumatic massive hemorrhage demands immediately available first-aid supplies with reduced operation time and good surgical compliance. In-situ crosslinking gels that are flexibly adapting to the wound shape have a promising potential, but it is still hard to achieve fast gelation, on-demand adhesion, and wide feasibility at the same time. Methods : A white-light crosslinkable natural milk-derived casein hydrogel bioadhesive is presented for the first time. Benefiting from abundant tyrosine residues, casein hydrogel bioadhesive was synthesized by forming di-tyrosine bonds under white light with a ruthenium-based catalyst. We firstly optimized the concentration of proteins and initiators to achieve faster gelation and higher mechanical strength. Then, we examined the degradation, cytotoxicity, tissue adhesion, hemostasis, and wound healing ability of the casein hydrogels to study their potential to be used as bioadhesives. Result : Rapid gelation of casein hydrogel is initiated with an outdoor flashlight, a cellphone flashlight, or an endoscopy lamp, which facilitates its usage during first-aid and minimally invasive operations. The rapid gelation enables 3D printing of the casein hydrogel and excellent hemostasis even during liver hemorrhage due to section injury. The covalent binding between casein and tissue enables robust adhesion which can withstand more than 180 mmHg blood pressure. Moreover, the casein-based hydrogel can facilitate post-traumatic wound healing caused by trauma due to its biocompatibility. Conclusion : Casein-based bioadhesives developed in this study pave a way for broad and practical application in emergency wound management.

      • SCIESCOPUSKCI등재

        Distributed Power and Rate Control for Cognitive Radio Networks

        Wang, Wei,Wang, Wenbo,Zhu, Yajun,Peng, Tao The Korea Institute of Information and Commucation 2009 Journal of communications and networks Vol.11 No.2

        In this paper, a distributed power and end-to-end rate control algorithm is proposed in the presence of licensed users. By Lagrangian duality theory, the optimal power and rate control solution is given for the unlicensed users while satisfying the interference temperature limits to licensed users. It is obtained that transmitting with either 0 or the maximum node power is the optimal scheme. The synchronous and asynchronous distributed algorithms are proposed to be implemented at the nodes and links. The convergence of the proposed algorithms are proved. Finally, further discussion on the utility-based fairness is provided for the proposed algorithms. Numerical results show that the proposed algorithm can limit the interference to licensed user under a predefined threshold.

      • KCI등재

        Influence of pump start-up mode on the stability of mixed-flow pumps

        Zhenbo Tang,Guojun Zhu,Jianjun Feng,Yajun Wu,Kai Liu,Qiang Lu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.6

        To analyse the influence of the start-up mode on the stability of the mixed-flow pump, start-up experiments are performed. And the external characteristic parameters, pressure fluctuation and shaft vibration data are collected by a multi-channel synchronous signal acquisition system during start-up. These data are analyzed by the time-frequency analysis method and wavelet partial coherence analysis method. Results reveal a positive correlation between the impeller angular acceleration and the time change rate of external characteristic parameters. During the start-up process, the variation law of the external characteristic parameters similar with the law of impeller rotating speed rise. The amplitude of the shaft vibration has a positive correlation with the start-up acceleration of the impeller. The influence of guide vane pressure fluctuations on the shaft vibrations is greater within 0~2 s after the start of the mixedflow pump. With the strart-up time extension, the partial coherence between the shaft vibration and the pressure fluctuations in guide vane is enhanced in low frequency band, which increases the risk of flow-induced vibration of the pump shaft.

      • KCI등재

        Large-scale production of foreign proteins via the novel plant transient expression system in Pisum sativum L

        Liang Li,Xiufeng Wang,Liping Yang,Yajun Fan,Xiaojuan Zhu,Xingzhi Wang 한국식물생명공학회 2016 Plant biotechnology reports Vol.10 No.4

        Transient expression of foreign genes by Agrobacterium infiltration is a versatile technique that can be used as a rapid tool for functional protein production in plants. A reproducible protocol of large-scale production of foreign proteins via the novel plant transient expression system in Pisum sativum L. was established in our study. Non-detached plants from soil-independent culture were used as the target organ, and vacuum infiltrating mediated by Agrobacterium tumefaciens harboring green fluorescent protein (GFP) gene was performed. Step-by-step optimization was performed and showed that the quality of plant material as well as agro-infiltration conditions were the major factors influencing the gene expression. Monitoring the transient GFP expression daily, the highest expression level was achieved on the 8th day post-infiltration. Evidence of anti-acidic fibroblast growth factorsingle chain variable fragment (anti-aFGF-scFv) gene expression in pea seedling was also achieved using agromediated vacuum infiltration system. Our work proves that the system is suitable for the largescale production of pharmaceutical proteins. The in planta infiltration system described here provides a powerful tool to explore easily gene expression in Pisum sativum L. avoiding tissue culture steps and the labor-intensive generation of transgenic plants.

      • KCI등재

        Distributed Power and Rate Control for Cognitive Radio Networks

        Wei Wang,Wenbo Wang,Tao Peng,Yajun Zhu 한국통신학회 2009 Journal of communications and networks Vol.11 No.2

        In this paper, a distributed power and end-to-end rate control algorithm is proposed in the presence of licensed users. By Lagrangian duality theory, the optimal power and rate control solution is given for the unlicensed users while satisfying the interference temperature limits to licensed users. It is obtained that transmitting with either 0 or the maximum node power is the optimal scheme. The synchronous and asynchronous distributed algorithms are proposed to be implemented at the nodes and links. The convergence of the proposed algorithms are proved. Finally, further discussion on the utility-based fairness is provided for the proposed algorithms. Numerical results show that the proposed algorithm can limit the interference to licensed user under a predefined threshold.

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