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Construction and Commissioning of the KSTAR Current Feeder System
Park, Y.M.,Lee, Y.J.,Yaung-Soo Kim,Woo, I.S.,Kwag, S.W.,Chang, Y.B.,Song, N.H.,Park, H.T.,Kim, C.S.,Lee, K.S.,Bang, E.N.,Chu, Y.,Yonekawa, H.,Park, K.R.,Yang, H.L.,Ha, T.H.,Bak, J.S. IEEE 2009 IEEE transactions on applied superconductivity Vol.19 No.3
<P>The function of the current feeder system (CFS) is for conducting large currents from the power supplies to the KSTAR superconducting (SC) magnets. The CFS consists of SC bus-lines, joints, and current leads. The bus-line conductor is a circular cable-in-conduit conductor (CICC), which consists of a 4.5 mm thick stainless steel 316L seamless pipe containing 324 strands of chrome coated NbTi superconductor and 243 strands of OFHC. The ends of the CICC are assembled with specially designed lap joints. The joining resistance is controlled to less than 2.5 nano-ohm to minimize Joule heating. The outer surfaces of the CICC were electrically insulated up to 15 kV with jackets made of Kapton film and prepreged E-glass tape. Helically wrapped conducting fiber was used to measure the voltages of bus-line quenches. Two pairs of prototype brass leads for poloidal field (PF) and toroidal field (TF) coils have been fabricated and tested up to the currents of 26 kA for the PF leads and 35 kA for the TF leads. The test results satisfied all the requirements so that all 18 leads were manufactured and assembled on site. This paper will describe the detailed manufacturing progress and commissioning results of the KSTAR CFS.</P>
Ng, Maggie C.Y.,Park, Kyong Soo,Oh, Bermseok,Tam, Claudia H.T.,Cho, Young Min,Shin, Hyoung Doo,Lam, Vincent K.L.,Ma, Ronald C.W.,So, Wing Yee,Cho, Yoon Shin,Kim, Hyung-Lae,Lee, Hong Kyu,Chan, Juliana American Diabetes Association 2008 Diabetes Vol.57 No.8
<P><B>OBJECTIVE—</B> Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity and confirmed <I>TCF7L2</I> as the major type 2 diabetes gene to date in Europeans. However, the implications of these genes in Asians are unclear.</P><P><B>RESEARCH DESIGN AND METHODS—</B> We studied 13 associated single nucleotide polymorphisms from these genes in 3,041 patients with type 2 diabetes and 3,678 control subjects of Asian ancestry from Hong Kong and Korea.</P><P><B>RESULTS—</B> We confirmed the associations of <I>TCF7L2</I>, <I>SLC30A8</I>, <I>HHEX</I>, <I>CDKAL1</I>, <I>CDKN2A</I>/<I>CDKN2B</I>, <I>IGF2BP2</I>, and <I>FTO</I> with risk for type 2 diabetes, with odds ratios ranging from 1.13 to 1.35 (1.3 × 10<SUP>−12</SUP> < <I>P</I><SUB>unadjusted</SUB> < 0.016). In addition, the A allele of rs8050136 at <I>FTO</I> was associated with increased BMI in the control subjects (<I>P</I><SUB>unadjusted</SUB> = 0.008). However, we did not observe significant association of any genetic variants with surrogate measures of insulin secretion or insulin sensitivity indexes in a subset of 2,662 control subjects. Compared with subjects carrying zero, one, or two risk alleles, each additional risk allele was associated with 17% increased risk, and there was an up to 3.3-fold increased risk for type 2 diabetes in those carrying eight or more risk alleles. Despite most of the effect sizes being similar between Asians and Europeans in the meta-analyses, the ethnic differences in risk allele frequencies in most of these genes lead to variable attributable risks in these two populations.</P><P><B>CONCLUSIONS—</B> Our findings support the important but differential contribution of these genetic variants to type 2 diabetes and obesity in Asians compared with Europeans.</P>
Kim, Chan Soo,Suh, Kune Y.,Rempe, Joy L.,Cheung, Fan B.,Kim, Sang B. Elsevier 2005 Nuclear engineering and design Vol.235 No.20
<P><B>Abstract</B></P><P>Film boiling heat transfer coefficients for a downward-facing hemispherical surface are measured from the quenching tests in Downward-Boiling Experiment Laminar Transition Apparatus (DELTA). Two test sections are made of copper to maintain low Biot numbers. The outer diameters of the hemispheres are 120 and 294mm, respectively. The thickness of all the test sections is 30mm. The effect of diameter on film boiling heat transfer is quantified utilizing results obtained from the test sections. The measured data are compared with the numerical predictions from laminar film boiling analysis. The measured heat transfer coefficients are found to be greater than those predicted by the conventional laminar flow theory on account of the interfacial wavy motion incurred by the Helmholtz instability. Incorporation of the wavy motion model considerably improves the agreement between the experimental and numerical results in terms of heat transfer coefficient. In addition, the film boiling was visualized using a digital camera.</P>
Nitric Oxide Donor 첨가가 구리 결핍 배아의 발달과 Nitric Oxide 하위 신호전달체계에 미치는 영향
양수진(Yang Soo Jin),Keen Carl L,Uriu-Adams,Janet Y 韓國營養學會 2008 Journal of Nutrition and Health Vol.41 No.8
본 연구는 착상 후 단계의 쥐 배아와 난황낭을 대상으로 구리 결핍이 NO 하부 신호전달체계에 영향을 주는지를 알아보기 위한 것으로, 연구 결과는 다음과 같이 요약할 수 있다. 첫째, 구리 결핍은 정상적인 배아 및 난황낭 발달을 억제하고, NO의 생물학적 이용도와 아세틸콜린에 대한 NO dose-response를 낮추었다. 둘째, 구리 결핍은 NO의 하부 신호전달 물질인 cGMP 수준을 감소시켰으나, NO/cGMP하부 신호전달체계 표적 중 하나인 P-VASP에는 영향을 미치지 않았다. 셋째, 구리 결핍 배양액에 NO donor를 첨가하는 것은 구리 결핍 배아와 난황낭의 기형 발생 빈도를 구리 정상군과 비슷한 수준으로 개선시켰다. 넷째, NO donor 첨가는 구리 결핍군에서 감소되었던 cGMP의 농도를 유의적으로 증가시켰지만, P-VASP에는 영향을 미치지 않았다. 상기 연구 결과들은 구리 결핍으로 인한 NO의 생물학적 이용도의 감소가 기형발생의 주요 발생 기전이라는 것을 뒷받침하고 있다. 또한, 임상적으로 임신 기간 중 적절한 구리 섭취의 중요성을 강조한다. One suggested mechanism underlying copper (Cu) deficiency teratogenicity is a low availability of nitric oxide (NO), a signaling molecule which is essential in developmental processes. Increased superoxide anions secondary to decreased activities of Cu-zinc superoxide dismutase (Cu-Zn SOD) in Cu deficiency can interact with NO to form peroxynitrite, which can nitrate proteins at tyrosine residues. In addition, peroxynitrite formation can limit NO bioavailability. We previously reported low NO availability and increased protein nitration in Cu deficient (Cu-) embryos. In the current study, we tested whether Cu deficiency alters downstream signaling of NO by assessing cyclic GMP (cGMP) and phosphorylated vasodilator-stimulating phosphoprotein (VASP) levels, and whether NO supplementation can affect these targets as well as protein nitration. Gestation day 8.5 embryos from Cu adequate (Cu+) or Cu- dams were collected and cultured in either Cu+ or Cu- media for 48 hr. A subset of embryos was cultured in Cu- media supplemented with a NO donor (DETA/NONOate; 20 μM) and/or Cu-Zn SOD. Cu-/Cu- embryos showed a higher incidence of embryonic and yolk sac abnormalities, low NO availability, blunted dose-response in NO concentrations to increasing doses of acetylcholine, low mRNA expression of endothelial nitric oxide synthase (eNOS), increased levels of 3-nitrotyrosine (3-NT) compared to Cu+/Cu+ controls. cGMP concentrations tended to be low in Cu-/Cu- embryos, and they were significantly lower in Cu-/Cu- yolk sacs than in controls. Levels of phosphorylated VASP at serine 239 (P-VASP) were similar in all groups. NO donor supplementation to the Cu- media ameliorated embryonic and yolk sac abnormalities, and resulted in increased levels of cGMP without altering levels of P-VASP and 3-NT. Taken together, these data support the concept that Cu deficiency limits NO availability and alters NO/cGMP-dependent signaling in Cu- embryos and yolk sacs, which contributes to Cu deficiency-induced abnormal development.
Effect of stress evolution on microstructural behavior in U-Mo/Al dispersion fuel
Jeong, G.Y.,Kim, Yeon Soo,Jamison, L.M.,Robinson, A.B.,Lee, K.H.,Sohn, Dong-Seong ELSEVIER 2017 JOURNAL OF NUCLEAR MATERIALS Vol.487 No.-
<P><B>Abstract</B></P> <P>U-Mo/Al dispersion fuel irradiated to high burnup at high power (high fission rate) exhibited microstructural changes including deformation of the fuel particles, pore growth, and rupture of the Al matrix. The driving force for these microstructural changes was meat swelling resulting from a combination of fuel particle swelling and interaction layer (IL) growth. In some cases, pore growth in the interaction layers also contributed to meat swelling. The main objective of this work was to determine the stress distribution within the fuel meat that caused these phenomena. A mechanical equilibrium between the stress generated by fuel meat swelling and the stress relieved by fission-induced creep in the meat constituents (U-Mo particles, Al matrix, and IL) was considered. Test plates with well-recorded fabrication data and irradiation conditions were used, and their post-irradiation examination (PIE) data was obtained. ABAQUS finite element analysis (FEA) was utilized to simulate the microstructural evolution of the plates. The simulation results allowed for the determination of effective stress and hydrostatic stress exerted on the meat constituents. The effects of fabrication and irradiation parameters on the stress distribution that drives microstructural evolutions, such as pore growth in the IL and Al matrix rupture, were investigated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Post-irradiation data for irradiated miniplates were analyzed by using their optical microscopy images. </LI> <LI> ABAQUS finite element analysis (FEA) package was utilized to simulate the microstructural evolution of the selected plates. </LI> <LI> Stresses were assessed to analyze their effects on microstructural changes during irradiation. </LI> </UL> </P>
Im, Myung,Kim, Soo Y,Sohn, Kyung C,Choi, Dae K,Lee, Young,Seo, Young J,Kim, Chang D,Hwang, Yul L,Zouboulis, Christos C,Lee, Jeung H The Society for Investigative Dermatology, Inc 2012 The Journal of investigative dermatology Vol.132 No.12
Acne vulgaris is the most common disease of the pilosebaceous unit. The pathogenesis of this inflammatory disease is complex, involving increased sebum production and perifollicular inflammation. To identify effective agents for factors that induce acne vulgaris, we explored the pharmacological potential of epigallocatechin-3-gallate (EGCG), which has been widely investigated as an anti-proliferative and anti-inflammatory agent. In this study, we demonstrated that topical application of EGCG to rabbit auricles reduced the size of the sebaceous glands. When applied to cultured human SZ95 sebocytes, EGCG strongly suppressed cell proliferation and lipogenesis. These actions of EGCG were reproduced in IGF-I-differentiated SZ95 sebocytes. To investigate the anti-inflammatory potential of EGCG, we evaluated pro-inflammatory cytokine synthesis in IGF-I-differentiated SZ95 sebocytes and found that expression of IL-1, IL-6, and IL-8 was decreased. These results provide early evidence that EGCG is an effective candidate for acne therapy whose mechanisms of action in IGF-I-differentiated SZ95 sebocytes include the inhibition of lipogenesis and inflammation.