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      • Cardiovascular effects of ethanol extract of Rubus chingii Hu (Rosaceae) in rats: an in vivo and in vitro approach.

        Su, X H,Duan, R,Sun, Y Y,Wen, J F,Kang, D G,Lee, H S,Cho, K W,Jin, S N The Society 2014 Journal of physiology and pharmacology Vol.65 No.3

        <P>Rubus chingii Hu (Rosaceae) is an important traditional Chinese medicine that has been used to improve function of the kidney and treat excessive polyuria. However, the effects of Rubus chingii on the cardiovascular system and its pharmacological mechanisms of action have not been studied. The aim of the present study was to evaluate the cardiovascular effects of ethanol extract of Rubus chingii (ERC) in rats. The changes in systolic blood pressure and heart rate of rats and vascular tone of aortic rings in in vitro were measured using pressure transducer and force transducer, respectively, connected to a multichannel recording system. ERC decreased systolic blood pressure and heart rate in a concentration-dependent manner. ERC induced vasorelaxation in a concentration-dependent manner. The ERC-induced vasorelaxation was not observed in the absence of the endothelium. The vasorelaxant effect of ERC was significantly attenuated by inhibition of endothelial NO synthase (eNOS), soluble guanylyl cyclase (sGC), or Ca(2+) entry from extracellular sources with L-NAME, ODQ, diltiazem, or extracellular Ca(2+) depletion, respectively. Similarly, an inhibition of Akt with wortmannin attenuated the ERC-induced vasorelaxation. Modulators of the store-operated Ca(2+) entry, thapsigargin, Gd(3+), and 2-aminoethyl diphenylborinate markedly attenuated the ERC-induced vasorelaxation. Furthermore, 4-aminopyridine an inhibitor of voltage-dependent K(+) (KV) channel, significantly attenuated the ERC-induced vasorelaxation. However, tetraethylammonium and glibenclamide, had no significant effect on the ERC-induced vasorelaxation. Indomethacin, atropine, and propranolol had no effects on the ERC-induced vasorelaxation. The present study demonstrates that ERC induces vasorelaxation via endothelium-dependent two-step signaling: an activation of the Ca(2+)-eNOS-NO signaling in the endothelial cells and then subsequent stimulation of the NO-sGC-cGMP-KV channel signaling in the vascular smooth muscle cells. The Akt-eNOS pathway is also suggested to be involved in this relaxation. Also, the findings suggest that the ERC-induced vasorelaxation is closely related to the hypotensive action of the agent.</P>

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        Stochastic micro-vibration response characteristics of a sandwich plate with MR visco-elastomer core and mass

        Z. G. Ying,Y. Q. Ni,Y.F. Duan 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.16 No.1

        The magneto-rheological visco-elastomer (MRVE) is used as a smart core to control the stochastic micro-vibration of a sandwich plate with supported mass. The micro-vibration response of the sandwich plate with MRVE core and supported mass under stochastic support motion excitations is studied and compared to evaluate the vibration suppression capability. The effects of the supported mass and localized magnetic field on the stochastic micro-vibration response of the MRVE sandwich plate are taken into account. The dynamic characteristics of the MRVE core in micro-vibration are described by a non-homogeneous complex modulus dependent on vibration frequency and controllable by applied magnetic fields. The partial differential equations for the coupled transverse and longitudinal motions of the MRVE sandwich plate with supported mass are derived from the dynamic equilibrium, constitutive and geometric relations. The simplified ordinary differential equations are obtained for the transverse vibration of the MRVE sandwich plate under localized magnetic fields. A frequency-domain solution method for the stochastic micro-vibration response of sandwich plates with supported mass is developed based on the Galerkin method and random vibration theory. The expressions of frequency-response functions, response power spectral densities and root-mean-square velocity responses of the plate in terms of the one-third octave frequency band are obtained for micro-vibration evaluation. Finally, numerical results are given to illustrate the large response reduction capacity of the MRVE sandwich plate with supported mass under stochastic support motion excitations, and the influences of MRVE parameters, supported mass and localized magnetic field placement on the micro-vibration response.

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        Stochastic stability control analysis of an inclined stay cable under random and periodic support motion excitations

        Z.G. Ying,Y.Q. Ni,Y.F. Duan 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.6

        The stochastic stability control of the parameter-excited vibration of an inclined stay cable with multiple modes coupling under random and periodic combined support disturbances is studied by using the direct eigenvalue analysis approach based on the response moment stability, Floquet theorem, Fourier series and matrix eigenvalue analysis. The differential equation with time-varying parameters for the transverse vibration of the inclined cable with control under random and deterministic support disturbances is derived and converted into the randomly and deterministically parameter-excited multi-degree-of-freedom vibration equations. As the stochastic stability of the parameter-excited vibration is mainly determined by the characteristics of perturbation moment, the differential equation with only deterministic parameters for the perturbation second moment is derived based on the Itô stochastic differential rule. The stochastically and deterministically parameter-excited vibration stability is then determined by the deterministic parameter-varying response moment stability. Based on the Floquet theorem, expanding the periodic parameters of the perturbation moment equation and the periodic component of the characteristic perturbation moment expression into the Fourier series yields the eigenvalue equation which determines the perturbation moment behavior. Thus the stochastic stability of the parameter-excited cable vibration under the random and periodic combined support disturbances is determined directly by the matrix eigenvalues. The direct eigenvalue analysis approach is applicable to the stochastic stability of the control cable with multiple modes coupling under various periodic and/or random support disturbances. Numerical results illustrate that the multiple cable modes need to be considered for the stochastic stability of the parameter-excited cable vibration under the random and periodic support disturbances, and the increase of the control damping rather than control stiffness can greatly enhance the stochastic stability of the parameter-excited cable vibration including the frequency width increase of the periodic disturbance and the critical value increase of the random disturbance amplitude.

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        Stochastic vibration suppression analysis of an optimal bounded controlled sandwich beam with MR visco-elastomer core

        Z.G. Ying,Y.Q. Ni,Y.F. Duan 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.1

        To control the stochastic vibration of a vibration-sensitive instrument supported on a beam, the beam is designed as a sandwich structure with magneto-rheological visco-elastomer (MRVE) core. The MRVE has dynamic properties such as stiffness and damping adjustable by applied magnetic fields. To achieve better vibration control effectiveness, the optimal bounded parametric control for the MRVE sandwich beam with supported mass under stochastic and deterministic support motion excitations is proposed, and the stochastic and shock vibration suppression capability of the optimally controlled beam with multi-mode coupling is studied. The dynamic behavior of MRVE core is described by the visco-elastic Kelvin-Voigt model with a controllable parameter dependent on applied magnetic fields, and the parameter is considered as an active bounded control. The partial differential equations for horizontal and vertical coupling motions of the sandwich beam are obtained and converted into the multi-mode coupling vibration equations with the bounded nonlinear parametric control according to the Galerkin method. The vibration equations and corresponding performance index construct the optimal bounded parametric control problem. Then the dynamical programming equation for the control problem is derived based on the dynamical programming principle. The optimal bounded parametric control law is obtained by solving the programming equation with the bounded control constraint. The controlled vibration responses of the MRVE sandwich beam under stochastic and shock excitations are obtained by substituting the optimal bounded control into the vibration equations and solving them. The further remarkable vibration suppression capability of the optimal bounded control compared with the passive control and the influence of the control parameters on the stochastic vibration suppression effectiveness are illustrated with numerical results. The proposed optimal bounded parametric control strategy is applicable to smart visco-elastic composite structures under deterministic and stochastic excitations for improving vibration control effectiveness.

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        Stochastic vibration response of a sandwich beam with nonlinear adjustable visco-elastomer core and supported mass

        Z. G. Ying,Y. Q. Ni,Y. F. Duan 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.64 No.2

        The stochastic vibration response of the sandwich beam with the nonlinear adjustable visco-elastomer core and supported mass under stochastic support motion excitations is studied. The nonlinear dynamic properties of the visco-elastomer core are considered. The nonlinear partial differential equations for the horizontal and vertical coupling motions of the sandwich beam are derived. An analytical solution method for the stochastic vibration response of the nonlinear sandwich beam is developed. The nonlinear partial differential equations are converted into the nonlinear ordinary differential equations representing the nonlinear stochastic multi-degree-of-freedom system by using the Galerkin method. The nonlinear stochastic system is converted further into the equivalent quasi-linear system by using the statistic linearization method. The frequencyresponse function, response spectral density and mean square response expressions of the nonlinear sandwich beam are obtained. Numerical results are given to illustrate new stochastic vibration response characteristics and response reduction capability of the sandwich beam with the nonlinear visco-elastomer core and supported mass under stochastic support motion excitations. The influences of geometric and physical parameters on the stochastic response of the nonlinear sandwich beam are discussed, and the numerical results of the nonlinear sandwich beam are compared with those of the sandwich beam with linear visco-elastomer core.

      • Optimal design of a viscous inertial mass damper for a taut cable by the fixed-points method

        S.L. Xu,Y. F. Duan,S.H. Dong,C.B. Yun 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.30 No.1

        The negative stiffness of an active or semi-active damper system has been proven to be very effective in reducingdynamic response. Therefore, energy dissipation devices possessing negative stiffness, such as viscous inertial mass dampers (VIMDs), have drawn much attention recently. The control performance of the VIMD for cable vibration mitigation has already been demonstrated by many researchers. In this paper, a new optimal design procedure for VIMD parameters for taut cable vibration control is presented based on the fixed-points method originally developed for tuned mass damper design. A model consisting of a taut cable and a VIMD installed near a cable end is studied. The frequency response function (FRF) of the cable under a sinusoidal load distributed proportionally to the mode shape is derived. Then, the fixed-points method is applied to the FRF curves. The performance of a VIMD with the optimal parameters is subsequently evaluated through simulations. A taut cable model with a tuned VIMD is established for several cases of external excitation. The performance of VIMDs using the proposed optimal parameters is compared with that in the literature. The results show that cable vibration can be significantly reduced using the proposed optimal VIMD with a relatively small amount of damping. Multiple VIMDs are applied effectively to reduce the cable vibration with multi-modal components.

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