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Lee, K.,Moon, H.Y.,Park, C.,Kim, O.R.,Ahn, E.,Lee, S.Y.,Park, H.E.,Ihm, S.H.,Seung, K.B.,Chang, K.,Yoon, T.J.,Lee, C.,Cheong, C.,Hong, K.S. Elsevier 2009 Current Applied Physics Vol.9 No.1
We have recently synthesized organic dye-incorporated silica-coated core-shell magnetic nanoparticles (MFSNs) that enable the detection of both fluorescence and magnetic properties in cells and tissues by using magnetic resonance imaging (MRI). Furthermore, polyethylene glycolation of the surface of these MFSNs would render them more stable and biocompatible, and thus allow their in vivo use as a circulating agent with a long half-life. Atherosclerotic vascular diseases are the leading cause of death worldwide. A noninvasive diagnostic imaging method is required to identify vulnerable plaques prior to the occurrence of a clinical event. Macrophages are the key cellular mediators in the pathogenesis of plaque inflammation and vulnerability. We evaluated whether the use of polyethylene glycolated (PEGylated) MFSNs could help in effectively detecting the macrophage activity in the aorta of apolipoprotein E (apoE)-deficient mice. PEGylated MFSNs (Fe, 30mg/kg) were injected via the tail vein in 1.2% cholesterol-fed 30-week-old apoE-deficient mice. After 24h, ex vivo MRI was carried out. The atheromas were then observed by confocal laser scanning microscopy (CLSM), and immunohistochemical staining targeted toward the macrophages was performed. Ex vivo MRI demonstrated robust enhancement of the atherosclerotic plaques along the aortic wall. CLSM images showed accumulation of PEGylated MFSNs in the atherosclerotic plaques, and histological examination revealed the localization of MFSNs in the macrophages present in the lesion. Therefore, PEGylated MFSNs could function as an effective multimodal imaging agent in the identification of macrophage activity in atherosclerotic plaques.
非晶質(Fe_(1-x)Ni_x)_80B_20 合金의 結晶化 過程에 대한 速度論的 硏究
오병현,김윤배,임영언,김택기 충남대학교 공업교육연구소 1984 論文集 Vol.7 No.2
The thermal stability for the amorphous (Fe_(1-x)Ni_x)_80 B20 alloys has been studied systematically through DTA, X-ray diffraction pattern and the electrical resistance change response to temperature and time variations. 1) The crystallization temperature decreases with Ni content from 770°K(X=0.1) to 670°K(X=0.6) at 5℃/min heating rate. 2) The crystallization activation energy decreases with Ni content from 88.4kcal/mole(X=0.2) to 62.6kcal/mole (X=0.6) 3) Phase transformation by the crystallization occurs as follows ⅰ) X≤0.3 : Amorphous → γ(f.c.c) + Fe_2B (Tetragonal) ⅱ) X=0.6 : Amorphous → γ(f.c.c) + Ni(f.c.c) + Ni_3B(Orthorhombic)
Lee, J.E.,Lee, Y.H.,Kim, S.Y.,Kim, Y.G.,Moon, J.Y.,Jeong, K.H.,Lee, T.W.,Ihm, C.G.,Kim, S.,Kim, K.H.,Kim, D.K.,Kim, Y.S.,Kim, C.D.,Park, C.W.,Lee, D.Y.,Lee, S.H. Elsevier 2016 Journal of chromatography Vol.1453 No.-
<P>The goal of this study is to identify systematic biomarker panel for primary nephrotic syndromes from urine samples by applying a non-target metabolite profiling, and to validate their utility in independent sampling and analysis by multiplex statistical approaches. Nephrotic syndrome (NS) is a nonspecific kidney disorder, which is mostly represented by minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous glomerulonephritis (MGN). Since urine metabolites may mirror disease-specific functional perturbations in kidney injury, we examined urine samples for distinctive metabolic changes to identify biomarkers for clinical applications. We developed unbiased multi component covarianced models from a discovery set with 48 samples (12 healthy controls, 12 MCD, 12 FSGS, and 12 MGN). To extensively validate their diagnostic potential, new batch from 54 patients with primary NS were independently examined a year after. In the independent validation set, the model including citric acid, pyruvic acid, fructose, ethanolamine, and cysteine effectively discriminated each NS using receiver operating characteristic (ROC) analysis except MCD-MGN comparison; nonetheless an additional metabolite multi-composite greatly improved the discrimination power between MCD and MGN. Finally, we proposed the re-constructed metabolic network distinctively dysregulated by the different NSs that may deepen comprehensive understanding of the disease mechanistic, and help the enhanced identification of NS and therapeutic plans for future. (C) 2016 Elsevier B.V. All rights reserved.</P>
Battery performance of PMMA-grafted PE separators prepared by pre-irradiation grafting technique
Gwon, S.J.,Choi, J.H.,Sohn, J.Y.,Lim, Y.M.,Nho, Y.C.,Ihm, Y.E. Korean Society of Industrial and Engineering Chemi 2009 Journal of industrial and engineering chemistry Vol.15 No.5
Poly(methyl methacrylate)-grafted polyethylene (PE-g-PMMA) separators were prepared by pre-irradiation grafting technique of methyl methacrylate onto a commercial polyethylene separator. The prepared separators were characterized by using charge/discharge (C/D) cycling test, AC impedance, and thermal stability analyses. Thermal shrinkage (TS) of the PE-g-PMMA separators decreased with an increasing degree of grafting up to 70% above which it was saturated. The PE-g-PMMA separators showed a better oxidation stability on the anode up to 5V and a better cycle life performance than the original PE separator. These characteristics make the prepared separators suitable for applications in high voltage secondary lithium batteries.
Choi, J.H.,Gwon, S.J.,Shon, J.Y.,Jung, C.H.,Ihm, Y.E.,Lim, Y.M.,Nho, Y.C. Korean Society of Industrial and Engineering Chemi 2008 Journal of industrial and engineering chemistry Vol.14 No.1
Polystyrene-grafted poly(vinylidene fluoride) (PVDF-g-PS) membranes were prepared by simultaneous γ-irradiation-induced graft polymerization. The morphological changes of the prepared membranes were investigated by scanning electron microscopy. The degree of grafting (DOG) increased with increasing absorption doses. The degree of crystallinity upon grafting was found to decrease due to the formation of amorphous polystyrene layer. The grafted membranes showed better electrolyte uptake and retention ability compared to the ungrafted membrane. The ionic conductivity of the membrane with LiClO<SUB>4</SUB>/γ-butyrolactone-based electrolyte increased with the increase in the DOG and reached 2.50mS/cm for the highest sample.
Lee, K.,Park, C.,Moon, H.Y.,Ahn, E.,Park, H.E.,Ihm, S.H.,Seung, K.B.,Yoon, T.J.,Chang, K.,Lee, C.,Cheong, C.,Hong, K.S. Elsevier 2009 Current Applied Physics Vol.9 No.1
Magnetic ferrite nanoparticles (MNPs) are nano-sized magnets that distort the local magnetic field and alter the T<SUB>2</SUB> and T<SUB>2</SUB><SUP>*</SUP> of the water protons in the surrounding water molecules. This property renders MNPs a favorable negative MR contrast agent for biomedical applications. Silica coating and polyethylene glycolation confers additional stability and biocompatibility to the MNPs. Organic dyes incorporated into the silica shell enable the detection of MNP fluorescence by confocal laser scanning microscopy (CLSM). Mouse mesenchymal stem cells (mMSCs) in adult bone marrow can differentiate into cardiomyocytes. The mMSCs recruited in the region of myocardial infarction can express muscle-specific markers and increase the regional wall motion. Using MRI, we tracked the fate of MNP-labeled mMSCs injected into the infarcted myocardium. The mMSCs were effectively labeled with polyethylene-glycolated MNPs, as confirmed by CLSM. The MNP-labeled mMSCs were injected around and into the infarcted myocardium of C57/BL6 mice. Using MR, we successfully tracked the MNP-labeled mMSCs in the hearts of mice at 7d after inducing myocardial infarction. The localization of MNPs in the myocardium was validated by the in vivo and ex vivo MR images.