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Toward Industry 4.0 Components: Insights Into and Implementation of Asset Administration Shells
Ye, Xun,Hong, Seung Ho IEEE 2019 IEEE industrial electronics magazine Vol.13 No.1
<P>Diverse customer demands are increasing the need for improved flexibility, adaptability, and transparency of production processes; traditional manufacturing systems must change. To meet these requirements, cyberphysical system (CPS) technologies are being increasingly applied in industrial manufacturing, equipping production facilities with autonomous adaptation capabilities. This is achieved by incorporating physical objects and their virtual representations and enabling bidirectional information exchange between them.</P>
A Unifi ed Theory for Distortion Analysis of Thin-Walled Hollow Sections
Xun Xu,Huawen Ye,De-Yi Zhang,Shizhong Qiang 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.3
A novel unifi ed theory for distortion analysis of thin-walled hollow section has been proposed based on the Hellinger– Reissner variational principle to account for distortional shear deformation eff ects. Based on the proposed theory, a fi nite segment model has been developed and the method for determining the distortion functions of the cross-section has been proposed. The rationality of approaches for determining distortional shear stress has been analysed and it is concluded that Bredt’s pure distortion does not exist in the single-cell hollow section. Comparisons and analyses have been performed between the proposed theoretical model and the existing four groups of theories in distortion analysis of thin-walled hollow section. Eff ects of distortional warping shear stress on the shear deformation has been investigated and the results indicate that the distortional shear deformation eff ect results in a decrease of the distortional warping stresses and shear stresses but an increase of the transverse bending stresses. The numerical study indicates that the distortional shear deformation eff ects can be ignored and the fi rst derivative of the distortion angle can be employed as the distortional warping function for the conventional hollow sections of bridge structures.
Jin, Ye,Zhou, Li,Liang, Zhi-Yong,Jin, Ke-Min,Zhou, Wei-Xun,Xing, Bao-Cai Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Many factors, including molecular ones, were demonstrated to be associated with long-term prognosis of hepatocellular carcinoma (HCC). Thus far, the expression and clinicopathologic and prognostic significance of the carboxyl terminus of Hsp70-interacting protein (CHIP) in B-type hepatitis virus (HBV)-related HCC remain unknown. Materials and Methods: CHIP expression was detected by immunohistochemical staining of surgical samples from 79 patients with HCC with HBsAg positivity. In addition, correlations with clinicopathologic parameters and patient survival were evaluated. Results: It was found that positive CHIP staining was observed in tumor, but not non-tumor, tissues. High expression of CHIP was significantly related to larger tumor size, with marginally significant associations noted for presence of portal vein invasion and higher serum a-fetoprotein level. In addition, univariate analysis showed that high CHIP expression was a powerful predictor for dismal overall and disease-free survival. However, independent prognostic implications of CHIP were not proven in multivariate Cox regression test. Conclusions: CHIP is overexpressed in HBV-related HCC and is associated with unfavorable biological behavior as well as poor prognosis. However, its prognostic role needs to be further validated.
Ying Xu,Xun Zhou,Yuqi Zheng,Haochen Guan,Chensheng Fu,Jing Xiao,Zhibin Ye 대한고혈압학회 2020 Clinical Hypertension Vol.26 No.2
Background: To analyze the association between hypertension and urinary uric acid excretion in patients with chronic kidney disease (CKD). Methods: We screened 87 patients who had been admitted at the Dept of Nephrology, Huadong hospital between April 2017 to April 2019 who had completed 24-h ambulatory blood pressure monitoring and retained 24-h urine biochemical test specimens, thirty adult patients (age ≤ 65 years) with CKD 1–2 stages were recruited in the study. Pearson’s correlation analysis and multiple linear regression analysis were used to study the correlation of urinary uric acid excretion with ambulatory blood pressure values and the association of morning mean diastolic pressure (mMDP), night mean diastolic pressure (nMDP) and CV of dMSP (coefficient of variation of day mean systolic pressure) with fractional excretion of uric acid (FEua) and uric acid clearance rate (Cur). Independent T test was used to compare the differences of blood pressure values in FEua1 (FEua< 6.0%) and FEua2 (FEua≥6.0%) or Cur1 (Cur < 6.2 ml/min/1.73 m2 ) and Cur2 (Cur ≥ 6.2 ml/min/1.73m2 ) groups according to the median of FEua or Cur, respectively. Results: After adjusting for confounding factors, multiple linear regression analysis showed that FEua was positively associated with the mMDP and nMDP, Cur was positively associated with CV of dMSP. Levels of mMDP and nMDP in FEua1 group was lower than that in FEua2 group (both P < 0.05), level of CV of dMSP in Cur2 group were higher than that in Cur1 group (P < 0.01). Conclusions: We demonstrated that there is a positive correlation of FEua with morning and night mean diastolic pressure separately and Cur is positively related to CV of dMSP in CKD population. Monitoring the trend of urinary uric acid, may have a role in the early detection for hypertension or relative risks in the population of CKD.
Huang Zhi-Qun,Ye Jing,Liu Jing,Sun Li-Ying,Ong Hsiao Hui,Wei Yong-Hao,Fu Shu-Cai,Hu Xiao-Xun,Xu Yu,Wang De-Yun 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.4
Purpose: The abnormal expression of tight junction (TJ) plays a vital role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, there is no appropriate tool to distinguish and diagnose epithelial barrier defects in clinical practice. This study aimed to evaluate the predictive value of claudin-3 for epithelial barrier dysfunction in CRSwNP. Methods: In this study, TJ protein levels were evaluated by real-time quantitative polymerase chain reaction, immunofluorescent, and immunohistochemistry staining in control subjects and CRSwNP patients. The receiver operating characteristic (ROC) curve was created to assess the predictive value of TJ breakdown in clinical outcomes. In vitro, human nasal epithelial cells were cultured at the air-liquid interface to analyze the transepithelial electrical resistance (TER) level. Results: The expression levels of occludin, tricellulin, claudin-3, and claudin-10 were decreased (all P < 0.05), and those of claudin-1 was increased (P < 0.05) in CRSwNP patients as compared to healthy subjects. Additionally, claudin-3 and occludin levels were negatively correlated with the computed tomography score in CRSwNP (all P < 0.05), and the ROC curve indicated that the claudin-3 level had the most predictive accuracy in evaluating epithelial barrier disruption (area under the curve = 0.791, P < 0.001). Finally, the time-series analysis showed the highest correlation coefficient between TER and claudin-3 (cross-correlation function = 0.75). Conclusion: In this study, we suggest that claudin-3 could be a valuable biomarker for predicting nasal epithelial barrier defects and disease severity in CRSwNP.
An Incentive-Based Demand Response (DR) Model Considering Composited DR Resources
Yu, Mengmeng,Hong, Seung Ho,Ding, Yuemin,Ye, Xun Institute of Electrical and Electronics Engineers 2019 IEEE transactions on industrial electronics Vol.66 No.2
<P>Demand response (DR) has been recognized as a powerful tool to help mitigate power imbalances in a future smart energy system. This paper takes the point of view of a grid operator (GO) to establish an intraday resource trading framework, over which DR resources from different sectors (large industrial consumers and small- or middle-sized customers) are brought to the system level and are assessed by the GO along with the generators, with the aim of procuring the required system resources at minimal cost. Considering the distinct behaviors of the involved entities, Stackelberg game theory was adopted to analyze the coordination among the various decision makers. A unique Stackelberg equilibrium was identified that yields the optimal outcome for the resource trading game between the GO and demand-side participators. Simulation results demonstrated that the total procurement cost was minimized by applying the proposed approach.</P>
Xian-Liang Song,Sheng-Ying Ye,Ru Xie,Ling Yin,Xun Shi,Shu-Can Luo 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.9
−To study the role of ionic liquid as a solvent in whole cell biocatalyst, it is necessary to probe the effects of ionic liquid treatments on microbial activity. In this paper, Saccharomyces cerevisiae was selected as a test bacterium to study the effects of bmim[PF6] ionic liquid in different concentration on yeast activity through determining the growth curve, sugar degradation curve, microbial activity, colonial morphology and cell morphology. The results revealed that the growth of yeast is inhibited strongly in low concentration ionic liquid, while the lethal effect is feeble in high concentration ionic liquid. This result was totally different from that of supercritical CO_2 treatment or high concentration benzene methanol treatment which would lead most yeast to death.