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Chen, Xun,Zhang, Wentao,Zhang, Qian,Song, Tao,Yu, Zirui,Li, Zhong,Duan, Ning,Dang, Xiaoqian Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.6
Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.
Jian-Xun Chen,Heng-Quan Ran,Chang-Qin Sun 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.90 No.5
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could induce extensive and rapid future liver remnant hypertrophy. However, the morbidity for ALPPS is very high. This paper reports a modified ALPPS (associating microwave ablation and portal vein ligation for staged hepatectomy, AMAPS), which was successfully applied in the treatment of huge hepatocellular carcinoma with cirrhosis, and the procedure of operation was greatly simplified. Hence, AMAPS is feasible and safe in selected patients with primary hepatocellular carcinoma and cirrhosis.
Yuejiao Yang,Jie Chen,Liming Yang,Bin Chen,Zhenmei Sheng,Wenyun Luo,Guoping Sui,Xun Lu,Jianxin Chen 한국원자력학회 2016 Nuclear Engineering and Technology Vol.48 No.3
D-(+)-glucose (Glc) was added to the original Fricke polyvinyl alcoholeglutaraldehydeexylenol orange (FPGX) hydrogel dosimeter system to make a more stable FPGX hydrogelthree-dimensional dosimeter in this paper. Polyvinyl alcohol was used as a substrate,which was combined with Fricke solution. Various concentrations of Glc were tested withlinear relevant fitting for optimal hydrogel production conditions. The effects of variousformulations on the stability and sensitivity of dosimeters were evaluated. The resultsindicated that D-(+)-Glc, as a free radical scavenger, had a great effect on stabilizing thedose response related to absorbency and reducing the auto-oxidization of ferrous ions. Acareful doping with Glc could slow down the color change of the dosimeter before and afterradiation without any effect on the sensitivity of the dosimeter.
Robust Segmentation for Low Quality Cell Images from Blood and Bone Marrow
Chen Pan,Yi Fang,Xiang-guo Yan,Chong-xun Zheng 대한전기학회 2006 International Journal of Control, Automation, and Vol.4 No.5
Biomedical image is often complex. An applied image analysis system should deal with the images which are of quite low quality and are challenging to segment. This paper presents a framework for color cell image segmentation by learning and classification online. It is a robust two-stage scheme using kernel method and watershed transform. In first stage, a two-class SVM is employed to discriminate the pixels of object from background; where the SVM is trained on the data which has been analyzed using the mean shift procedure. A real-time training strategy is also developed for SVM. In second stage, as the post-processing, local watershed transform is used to separate clustering cells. Comparison with the SSF (Scale space filter) and classical watershed-based algorithm (those are often employed for cell image segmentation) is given. Experimental results demonstrate that the new method is more accurate and robust than compared methods.
Numerical simulation and experiments of magnetic flux leakage inspection in pipeline steel
Xun-Bo Li,Xiang Li,Liang Chen,Pei-Fu Feng,Hai-Dong Wang,Zuo-Ying Huang 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.1
The magnetic flux leakage (MFL) method is currently the most commonly used pipeline inspection technique. In this paper, numerical simulation and experimental investigation on defect inspection in pipeline steel using MFL were carried out. In theoretical analysis, typical three-dimensional (3D) defects were accurately modeled and detailed MFL signals in the test surface were calculated by 3D finite element method (FEM). To confirm the 3D FEM results, different artificial defects were made and the MFL experiments were performed. The experimental study demonstrated that the results were agreement with the 3D FEM result. The results show that the 3D FEM is an effective analysis method for pipeline steel MFL inspection.
Plasma treatment of multi-walled carbon nanotubes for lipase immobilization
Xun Cao,Rui Zhang,Wei-min Tan,Ce Wei,Jing Wang,Ze-meng Liu,Ke-quan Chen,Ping-Kai Ouyang 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.5
Plasma-modified multiwalled carbon nanotubes (MWNTs) were used as a support to immobilize lipase. The effects of vacuum plasma treatment power, vacuum plasma treatment time, immobilization temperature, immobilization time, and initial protein concentration of the lipase on the amount of lipase immobilized and on the subsequent activity of the immobilized lipase were investigated. The results showed that the adsorption capacity of the plasma-modified MWNTs could reach 0.15 g/g and that the maximal enzyme activity of the immobilized lipase was 520U/g under optimized conditions. Fourier transform infrared (FTIR) analysis and transmission electron microscopy (TEM) were used to characterize the properties of the plasma-modified MWNTs and plasma-modified MWNTslipase, and the results showed that the lipase was successfully immobilized on the plasma-modified MWNTs. Also, the MWNTs-lipase produced an esterification rate of approximately 47% in the synthesis of polyethylene glycol (PEG)-aliphatic esters.