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RISS 인기검색어
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- 저자 : XuJun Zhang (검색결과 7 건)
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Zhang, Zhen,He, Xujun,Xu, Ji,Zhang, Genhua,Yang, Yue,Ma, Jie,Sun, Yuanshui,Ni, Haibin,Wang, Fengyong The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.2
Purpose: miR-205 is a tumor suppressor and plays an important role in tumor invasiveness. However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim of this study was to investigate the molecular mechanism of miR-205 in the regulation of EMT in GC invasion. Materials and Methods: Quantitative polymerase chain reaction (qPCR) was used to detect the expression of miR-205 in GC. Further, the correlation between the pathological parameters and prognosis of GC was statistically analyzed. A transwell model was used to evaluate the effect of miR-205-3p on the invasion and migration of GC cells. qPCR, western blotting, and luciferase assay were performed to analyze the relationship and target effects between miR-205-3p and the expression of zinc finger electron box binding homologous box 1 (ZEB1) and 2 (ZEB2). Results: We found that the levels of miR-205-3p were significantly lower (P<0.05) in GC tissues than in matched normal tissues. Additionally, the expression of miR-205-3p was related to the tumor invasion depth, lymph node metastasis, lymph node invasion, and tumor, node, metastasis stage. Patients with lower miR-205-3p expression levels in the tumors had a poorer prognosis. The in vitro assays indicated that miR-205-3p could affect the invasion ability and EMT of GC cells by targeting the expression of both ZEB1 and ZEB2. Conclusions: miR-205-3p promotes GC progression and affects the prognosis of patients by targeting both ZEB1 and ZEB2 to directly influence EMT.
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Zhen Zhang,Xujun He,Ji Xu,Genhua Zhang,Yue Yang,Jie Ma,Yuanshui Sun,Haibin Ni,Fengyong Wang 대한위암학회 2020 Journal of gastric cancer Vol.20 No.2
Purpose: miR-205 is a tumor suppressor and plays an important role in tumor invasiveness. However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim of this study was to investigate the molecular mechanism of miR-205 in the regulation of EMT in GC invasion. Materials and Methods: Quantitative polymerase chain reaction (qPCR) was used to detect the expression of miR-205 in GC. Further, the correlation between the pathological parameters and prognosis of GC was statistically analyzed. A transwell model was used to evaluate the effect of miR-205-3p on the invasion and migration of GC cells. qPCR, western blotting, and luciferase assay were performed to analyze the relationship and target effects between miR-205-3p and the expression of zinc finger electron box binding homologous box 1 (ZEB1) and 2 (ZEB2). Results: We found that the levels of miR-205-3p were significantly lower (P<0.05) in GC tissues than in matched normal tissues. Additionally, the expression of miR-205-3p was related to the tumor invasion depth, lymph node metastasis, lymph node invasion, and tumor, node, metastasis stage. Patients with lower miR-205-3p expression levels in the tumors had a poorer prognosis. The in vitro assays indicated that miR-205-3p could affect the invasion ability and EMT of GC cells by targeting the expression of both ZEB1 and ZEB2. Conclusions: miR-205-3p promotes GC progression and affects the prognosis of patients by targeting both ZEB1 and ZEB2 to directly influence EMT.
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Dong Liang,Zhang Xiaojin,Yan Xuhong,Shen Yifeng,Li Yulin,Yu Xujun 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.4
Purpose: Male infertility is a worldwide problem with limitations in the treatment. Phosphodiesterase-5 inhibitors (PDE5is) is the first choice for the treatment of erectile dysfunction, more and more studies show that it has a certain effect on male infertility in recent years. But there was currently no high quality of systematic review to evaluate the effects of PDE5is on semen quality. Materials and Methods: We retrieved the electronic databases of MEDLINE, PubMed, Web of Science, EMBASE, etc. Related randomized controlled trials (RCTs) were collected and selected up to May 20, 2020. We have searched literature with terms “male infertility”, “phosphodiesterase-5 inhibitors”, “PDE5i”, “Tadalafil”, “Sildenafil”, “Vardenafil”, “Udenafil”, “Avanafil”, “semen”, and “sperm”. Mean value and its standard deviation were used to perform quantitative analysis. All statistical analyses were conducted by RevMan 5.3 and Stata software. Results: There were a total of 1,121 participants in the nine included studies. There was a statistically significant improvement treated with PDE5is compared with sham therapy, which including sperm concentration (mean difference [MD]=1.96, 95% confidence interval [CI]=1.70–2.21, p<0.001; MD=3.22, 95% CI=1.96–4.48, p<0.001), straight progressive motility (%) Grade A (MD=3.71, 95% CI=2.21–5.20, p<0.001), sperm motility (MD=8.09, 95% CI=7.83–8.36, p<0.001), morphologically normal spermatozoa (%) (MD=0.67, 95% CI=0.20–1.15, p=0.005; MD=1.27, 95% CI=0.02–2.52, p=0.05), sperm abnormalities (%) (MD=-0.64, 95% CI=-0.81–-0.47, p<0.001), and progressive motile sperm (MD=5.34, 95% CI=3.87–6.81, p<0.001). Conclusions: In this meta-analysis of nine RCTs, treatment with PDE5is could improve some indicators of male sperm.
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Lin Li,Panpan Duan,Qingbo Xu,XuJun Zhang,JiaNing Chen,Feiya Fu,HongYan Diao,Xiangdong Liu 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9
Aiming to a durably antibacterial function, stable immobilization of silver nanoparticles (Ag NPs) on cottontextiles still represents challenging in textile industry. In the present work, by grafting oligomeric polyacrylic acid (PAA) ontocotton fiber surfaces, we effectively prepared the Ag NPs with controllable size on the fiber surface, which are of average sizeof 16.43 nm, and therefore achieved a desirable antibacterial durability. The oligomer PAA binder can give the modifiedfabrics with a remarkable antibacterial durability against washing, as the bacterial reduction rates against bothStaphylococcus aureus and Escherichia coli remained over 90 % even after 50 laundering cycles. Moreover, this graft toapproach using oligomeric PAA shows merits in maintaining the desired cotton properties such as flexibility, waterabsorptivity and vapor permeability. Finally, this finishing process ensures a reliable safety for human skin.
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Review of Vasectomy Complications and Safety Concerns
Yang Fang,Li Junjun,Dong Liang,Tan Kun,Huang Xiaopeng,Zhang Peihai,Liu Xiaozhang,Chang Degui,Yu Xujun 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.3
Vasectomy is a simple, safe, effective, and economical method used worldwide for long-term male contraception. As a sur-gical operation, it has short-term and long-term complications such as hematoma formation, infection, sterilization failure, sperm granulomas, short-term postoperative pain (nodal pain, scrotal pain, and ejaculation pain), and chronic pain syn-drome. Whether it increases the risk of autoimmune disease, cardiovascular disease, testicular cancer, or prostate cancer is still controversial. Changes in plasma concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone after vasectomy have also been studied, as well as the relation between vasectomy and sexual function. Sperm quality de-creases very slowly after vasectomy, and vasovasostomy and intracytoplasmic sperm injection could help a couple achieve a pregnancy if they change their minds at any point. We include a follow-up strategy and suggestions for follow-up care at the end of this review.
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Xu, Jun,Chen, Lie-Wen,Tsang, ManYee Betty,Wolter, Hermann,Zhang, Ying-Xun,Aichelin, Joerg,Colonna, Maria,Cozma, Dan,Danielewicz, Pawel,Feng, Zhao-Qing,Le Fè,vre, Arnaud,Gaitanos, Theodoros,Hartn American Physical Society 2016 Physical Review C Vol.93 No.4
<P>Transport simulations are very valuable for extracting physics information from heavy-ion-collision experiments. With the emergence of many different transport codes in recent years, it becomes important to estimate their robustness in extracting physics information from experiments. We report on the results of a transport-code-comparison project. Eighteen commonly used transport codes were included in this comparison: nine Boltzmann-Uehling-Uhlenbeck-type codes and nine quantum-molecular-dynamics-type codes. These codes have been asked to simulate Au + Au collisions using the same physics input for mean fields and for in-medium nucleon-nucleon cross sections, as well as the same impact parameter, the similar initialization setup, and other calculational parameters at 100 A and 400 A MeV incident energy. Among the codes we compare one-body observables such as rapidity and transverse flow distributions. We also monitor nonobservables such as the initialization of the internal states of colliding nuclei and their stability, the collision rates, and the Pauli blocking. We find that not completely identical initializations may have contributed partly to different evolutions. Different strategies to determine the collision probabilities and to enforce the Pauli blocking also produce considerably different results. There is a substantial spread in the predictions for the observables, which is much smaller at the higher incident energy. We quantify the uncertainties in the collective flow resulting from the simulation alone as about 30% at 100 A MeV and 13% at 400 A MeV, respectively. We propose further steps within the code comparison project to test the different aspects of transport simulations in a box calculation of infinite nuclear matter. This should, in particular, improve the robustness of transport model predictions at lower incident energies, where abundant amounts of data are available.</P>
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