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Chongli Xu,Yu Liu,Yuchen Gong,Xinping Duan,Xiaochun Tang,Mingjun Zhang,Daxin Pang,Liqing Yu,Hongwei Zhao,Hongsheng Ouyang 한국유전학회 2015 Genes & Genomics Vol.37 No.2
Although Niemann-Pick C1-Like 1 (NPC1L1)plays a key role in intestinal cholesterol absorption, regulatingcholesterol metabolism and maintaining cholesterolmetabolic homeostasis, the molecular mechanism ofNPC1L1 in lipid-metabolism disorders leading to liverdisease remains largely unknown. Previous studies haveshown that NPC1L1 is related with the development offatty liver. Therefore, we hypothesized that NPC1L1 playsan important role in lipid-metabolism disorders and liverdisease by affecting the transcription of certain genesinvolved in lipid synthesis. To further elucidate the functionof NPC1L1, especially in the liver, we used somaticcellnuclear transfer to establish transgenic pigs thatexpressed human NPC1L1 in their livers. We investigatedsuperoxide dismutase activities and the levels of free fattyacids and malondialdehyde, a biomarker of lipid peroxidation. Superoxide dismutase activities significantlydecreased, and free fatty acid and malondialdehyde levelssignificantly increased in the NPC1L1 transgenic pigs,indicating that the overexpression of NPC1L1 in the liverresulted in severe lipid peroxidation. Our findings suggestthat NPC1L1 plays an important role in lipid-metabolismdisorders and liver disease.
Spectral Analysis of the Moving System with Multi-object Based on V-system
Ruixia Song,Chenghua Li,Xiaochun Wang,Yena Wang,Yanqing Xu,Dongxu Qi (사)한국CDE학회 2013 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8
Based on an orthogonal function system over triangular domain, V-system, decomposing orthogonally a moving system with multiple moving objects into V-series, motion state of this moving system at different moment can be expressed in the frequency domain. To make full use of the advantage of the V-system, the capability to precisely express a 3D object group, each moving object is represented by a triangular mesh model, and then the energy curve data for the moving system is calculated by determining the coefficients of the V-series. The energy curve can be applied to the state analysis of the moving system. The relationship of energy curves of a moving system with different triangular mesh resolutions is analyzed. The experiment results show that there exist no strong dependence between energy curve and the resolution of 3D model, so when performing spectral analysis for a moving system, we can choose the model with low resolution, so that the computation can be reduced and the analysis efficiency can be improved. Finally, the mathematic relationship between energy of a moving system and some related variables is obtained by processing a large number of experimental data using the linear regression method. The characteristic of this study is reflected in the whole expression of a 3D model group, and the objects in the group are in motion.
Lingling Fu,Dunmin Lin,Qiaoji Zheng,Xiaochun Wu,Lang Wu,Hailing Sun,Yang Wan,Ximing Fan,Chenggang Xu 한국물리학회 2012 Current Applied Physics Vol.12 No.6
Lead-free ceramics (1-x)NaNbO3-xBi0.5Li0.5TiO3 have been fabricated by an ordinary sintering technique,and their electric properties and temperature characteristics have been studied. All the ceramics possess a perovskite structure with orthorhombic symmetry, indicating that (Bi0.5Li0.5)TiO3 diffuses into NaNbO3 lattices to form a new solid solution. A low (Bi0.5Li0.5)TiO3 doping level transforms the NaNbO3ceramics from antiferroelectric to ferroelectric. The ceramics with x ≤ 0.075 are normal ferroelectric, and the ferroelectric-paraelectric phase become diffusives with the doping level of Bi0.5Li0.5TiO3 increasing. As x increases, the Curie temperature of the ceramics decreases linearly, while the relative permittivity εr increases. 0.925NaNbO3e0.075(Bi0.5Li0.5)TiO3 ceramic exhibits the relatively large piezoelectric constant (d33 = 58 pC/N), high Curie temperature (TC = 228 ℃) and good temperature stability, suggesting that the ceramics are one of new possible candidates for lead-free piezoelectric materials. Lead-free ceramics (1-x)NaNbO3-xBi0.5Li0.5TiO3 have been fabricated by an ordinary sintering technique,and their electric properties and temperature characteristics have been studied. All the ceramics possess a perovskite structure with orthorhombic symmetry, indicating that (Bi0.5Li0.5)TiO3 diffuses into NaNbO3 lattices to form a new solid solution. A low (Bi0.5Li0.5)TiO3 doping level transforms the NaNbO3ceramics from antiferroelectric to ferroelectric. The ceramics with x ≤ 0.075 are normal ferroelectric, and the ferroelectric-paraelectric phase become diffusives with the doping level of Bi0.5Li0.5TiO3 increasing. As x increases, the Curie temperature of the ceramics decreases linearly, while the relative permittivity εr increases. 0.925NaNbO3e0.075(Bi0.5Li0.5)TiO3 ceramic exhibits the relatively large piezoelectric constant (d33 = 58 pC/N), high Curie temperature (TC = 228 ℃) and good temperature stability, suggesting that the ceramics are one of new possible candidates for lead-free piezoelectric materials.