http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Non-Association of IL-16 rs4778889 T/C Polymorphism with Cancer Risk in Asians: a Meta-analysis
Xu, Lin-Lin,Song, Zhi-Chun,Shang, Kun,Zhao, Li-Qin,Zhu, Zhan-Sheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
The IL-16 rs4778889 T/C polymorphism is associated with cancer risk. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. A comprehensive literature search was performed using PubMed, Embase and Web of Science databases. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. A total of 6 studies including 1,603 cases and 2,342 controls were identified. With all studies involved, results showed no statistically significant association between IL-16 rs4778889 T/C polymorphism and cancer risk (CC vs. CT+TT: OR=0.74, 95%CI:0.55-1.02, $P_h=0.15$; CC+CT vs. TT: OR=0.89, 95%CI: 0.72-1.10, $P_h=0.03$; CC vs. TT: OR=0.73, 95%CI: 0.53-1.00, $P_h=0.08$; CT vs. TT: OR=0.91, 95%CI: 0.79-1.05, $P_h=0.08$; C vs. T: OR=0.89, 95%CI: 0.74-1.07, $P_h=0.02$). In addition, the results were not changed when studies were stratified by cancer type. However, to verify our findings, it is essential to perform more well-designed studies with larger sample sizes in the future.
Song, Dae-Kyu,Jang, Youngho,Kim, June Hong,Chun, Kook-Jin,Lee, Deokhee,Xu, Zhelong The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.3
<P>Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea, appears to attenuate myocardial ischemia/reperfusion injury. We investigated the involvement of ATP-sensitive potassium (K<SUB>ATP</SUB>) channels in EGCG-induced cardioprotection. Isolated rat hearts were subjected to 30 min of regional ischemia and 2 hr of reperfusion. EGCG was perfused for 40 min, from 10 min before to the end of index ischemia. A nonselective K<SUB>ATP</SUB> channel blocker glibenclamide (GLI) and a selective mitochondrial K<SUB>ATP</SUB> (mK<SUB>ATP</SUB>) channel blocker 5-hydroxydecanoate (HD) were perfused in EGCG-treated hearts. There were no differences in coronary flow and cardiodynamics including heart rate, left ventricular developed pressure, rate-pressure product, +dP/dt<SUB>max</SUB>, and -dP/dt<SUB>min</SUB> throughout the experiments among groups. EGCG-treatment significantly reduced myocardial infarction (14.5±2.5% in EGCG 1 µM and 4.0±1.7% in EGCG 10 µM, <I>P</I><0.001 vs. control 27.2±1.4%). This anti-infarct effect was totally abrogated by 10 µM GLI (24.6±1.5%, <I>P</I><0.001 vs. EGCG). Similarly, 100 µM HD also aborted the anti-infarct effect of EGCG (24.1±1.2%, <I>P</I><0.001 vs. EGCG ). These data support a role for the K<SUB>ATP</SUB> channels in EGCG-induced cardioprotection. The mK<SUB>ATP</SUB> channels play a crucial role in the cardioprotection by EGCG.</P>
Yi-song Yu,Chun-gang Xu,Xiao-sen Li 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.59 No.-
Synergic effect of graphite nanoparticle(GN) and sodium dodecyl benzene sulfonate(SDBS) on the kinetics of CO2 hydrate formation were systematically investigated at 277.15 K and 3.5 MPa by measuring the surface tensions, CO2 consumption, storage capacity, hydrate formation rate, ratio of water converting to hydrate and induction time. The experimental results indicated that SDBS concentration change led to the dramatic change of the kinetics characteristics of hydrate formation. Relative to the pure water system, the gas consumption, hydrate storage, hydrate formation rate and ratio of water converting to hydrate were increased by 86.4%, 35.8%, 85.1% and 20% in the presence of GN(0.4%) + SDBS(0.04%), respectively.
The protective effects of BMSA1 and BMSA5-1-1 proteins against Babesia microti infection
Yu-Chun Cai,Chun Li Yang,Peng Song,Muxin Chen,Jia-Xu Chen 대한기생충학ㆍ열대의학회 2024 The Korean Journal of Parasitology Vol.62 No.1
The intracellular parasite Babesia microti is among the most significant species causinghuman babesiosis and is an emerging threat to human health worldwide. Unravelling thepathogenic molecular mechanisms of babesiosis is crucial in developing new diagnosticand preventive methods. This study assessed how priming with B. microti surface antigen1 (BHSA 1) and seroreactive antigen 5-1-1 (BHSA 5-1-1) mediate protection against B. microti infection. The results showed that 500 µg/ml rBMSA1 and rBMSA5-1-1 partiallyinhibited the invasion of B. microti in vitro by 42.0±3.0%, and 48.0±2.1%, respectively. Blood smears revealed that peak infection at 7 days post-infection (dpi) was 19.6%,24.7%, and 46.7% in the rBMSA1, rBmSA5-1-1, compared to the control groups (healthymice infected with B. microti only), respectively. Routine blood tests showed higher whiteblood cell, red blood cell counts, and haemoglobin levels in the 2 groups (BMSA1 andBMSA5 5-1-1) than in the infection control group at 0–28 dpi. Moreover, the 2 groups hadhigher serum interferon-γ, tumor necrosis factor-α and Interleukin-17A levels, and lowerIL-10 levels than the infection control group throughout the study. These 2 potential vaccine candidate proteins partially inhibit in vitro and in vivo B. microti infection and enhancehost immunological response against B. microti infection.
Effect of Turbulent Fluctuation on Settling Behavior of Dredged Slurry in Sheared Condition
Miao-miao Song,Gui-zhong Xu,Jie Yin,Wei-juan Geng,Zhi-yan Zhou,Cheng-chun Qiu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.4
For the land shortage problem upon the city development in coastal areas, it is of great importance to improve the overall understanding of the settlement behavior of dredged slurry and determine the required site water storage capacity as well as the mechanical properties of the newly formed dredged slurry. This paper presents an experimental investigation on the effect of turbulent fluctuation on the settling behavior of dredged slurry in sheared condition via a self-developed testing apparatus namely double cylinder settling column. Test results showed that the settling velocity of the soil-water interface initially increased then decreased with the increasing rotation speed of the inner column. The interface would disappear and a stable suspended layer was observed when the rotation speed was greater than 20 rad/min, where water contents and grain composition were not changed over the depth. The particle content was closer to that of the original sample as the rotation speed kept increasing in the suspended layer. It was found that the stabilized flocs were gradually broken down by the turbulence effect existing in the sheared slurry. Moreover, the stabilized flocs were losing the stability gradually as the flowing velocity increased till 10 rad/min and the floc structure was broken down completely once the flowing velocity was greater than 20 rad/min.
Dynamic changes of multi-notoginseng stem-leaf ginsenosides in reaction with ginsenosidase type-I
Yongkun Xiao,Chun-Ying Liu,임완택,Shuang Chen,Kangze Zuo,Hong Shan Yu,Jian-Guo Song,Long-Quan Xu,Tea-Hoo Yi,Feng Xie Jin 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.2
Background: Notoginseng stem-leaf (NGL) ginsenosides have not been well used. To improve their utilization, the biotransformation of NGL ginsenosides was studied using ginsenosidase type-I from Aspergillus niger g.848. Methods: NGL ginsenosides were reacted with a crude enzyme in the RAT-5D bioreactor, and the dynamic changes of multi-ginsenosides of NGL were recognized by HPLC. The reaction products were separated using a silica gel column and identified by HPLC and NMR. Results: All the NGL ginsenosides are protopanaxadiol-type ginsenosides; the main ginsenoside contents are 27.1% Rb3, 15.7% C-Mx1, 13.8% Rc, 11.1% Fc, 7.10% Fa, 6.44% C-Mc, 5.08% Rb2, and 4.31% Rb1. In the reaction of NGL ginsenosides with crude enzyme, the main reaction of Rb3 and C-Mx1 occurred through Rb3/C-Mx1/C-Mx; when reacted for 1 h, Rb3 decreased from 27.1% to 9.82 %, C-Mx1 increased from 15.5% to 32.3%, C-Mx was produced to 6.46%, finally into C-Mx and a small amount of C-K. When reacted for 1.5 h, all the Rb1, Rd, and Gyp17 were completely reacted, and the reaction intermediate F2 was produced to 8.25%, finally into C-K. The main reaction of Rc (13.8%) occurred through Rc/C-Mc1/CMc/ C-K. The enzyme barely hydrolyzed the terminal xyloside on 3-Oe or 20-O-sugar-moiety of the substrate; therefore, 9.43 g C-Mx, 6.85 g C-K, 4.50 g R7, and 4.71 g Fc (hardly separating from the substrate) were obtained from 50 g NGL ginsenosides by the crude enzyme reaction. Conclusion: Four monomer ginsenosides were successfully produced and separated from NGL ginsenosides by the enzyme reaction.
Primary Research on Theoretical Performance and Powder Supply Characteristics of Powder Rocket
Deng, Zhe,Hu, Chun-bo,Hu, Song-qi,Xu, Yi-hua The Society for Aerospace System Engineering 2015 International Journal of Aerospace System Engineer Vol.2 No.2
The powder propellant rocket which uses micron-sized particles as fuel is storable and costly. Functions like thrust control and multiple-ignition can be realized by changing powder mass flow rate. In this paper, we discuss the theoretical performance of bi-propellant and mono-propellant powder rocket. When used as the fluidization gas, helium can improve specific impulse dramatically. The stability of the powder feeding device is preliminarily quantified through metal/N2O powder rocket hot fire tests.
Zhao, Chang,Wang, Xu-Jie,Wang, Song,Feng, Wei-Hua,Shi, Lei,Yu, Chun-Peng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Purpose: To assess the effect and safety of lobaplatin combinated floxuridine /pirarubicin in transcatheter hepatic arterial chemoembolization(TACE) of unresectable primary liver cancer. Patients and Methods: TACE combined with the chemotherapy regimen was used to treat 34 unresectable primary liver cancer patients. DSA/MRI/CT/blood routine examinations were used to evaluate short term activity and toxicity after 4-5 weeks, the process being repeated if necessary. Results: Among the 34 cases, 1 (2.9%) showed a complete response, 21 (61.7%) a partial response, 8 (23.5%) stable disease, and 4 progressive disease, with a total effective rate of 67.6%. The content of alpha fetoprotein dropped by over 50% in 20 cases (58.8%). The rate of recovery was hepatalgia (88.2%), ascites (47.1%), appetite (55.9%), Performance Status(30.4%). The median follow-up time (MFT) was 281 days (63-558 days), and median progression-free survival was 118.5 days (95%, CI:88.8-148.2days). Adverse reactions (III-IV grade) were not common, with only 4 cases of vomiting and 2 cases of thrombocytopenia (III grade). Conclusions: Lobaplatin-based TACE is an effective and safe treatment for primary liver cancer.