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RISS 인기검색어
- 검색키워드
- 저자 : Xiuzhi Zhang (검색결과 4 건)
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Optimization of Mix Proportion of Self-compacting Concrete Based on Single Fluid Model
Xiuzhi Zhang,Chong Zhang,Mengdi Bi,Haibo Yang,Hailong Sun,Ru Mu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.3
The study aims to optimize the mix proportion of self-compacting concrete according to the workability and compressive strength. Firstly, based on computational fluid dynamics, the flowability and filling ability of self-compacting concrete were simulated by the single-fluid model to verify the single-fluid model. And then, the simulation of casting a pre-cambered composite beam was carried out. In the end, the mix proportion was optimized considering the filling ability and the compressive strength of self-compacting concrete. The results showed that increasing sand rate can improve the workability and decrease the rheological parameters of self-compacting concrete. The mixture with a 45% sand ratio in the case of 3% silica fume alone or 43% sand ratio in the case of 30% granulated blast furnace slag and 3% silica fume had adequate filling ability and excellent long term compressive strength. Moreover, the model can be used to simulate the filling ability and passing capacity of self-compacting concrete and the maximum error between the simulation results and the actual measured value is 4.80%. When the concrete mixture is considered to be uniform, namely, without considering the effect of the aggregates, the single-fluid model can simulate the casting of self-compacting concrete.
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Mi Zhang,Xindong Shui,Xiaoqing Zheng,Jong Eun Lee,Yingxue Mei,Ruomeng Li,Yuan Tian,Xiuzhi Zheng,Quling Wang,Long Wang,Dongmei Chen,Tao Zhang,Byeong Mo Kim,Jungho Kim,Tae Ho Lee 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.11
Breast cancer is one of the major malignancies in women, and most related deaths are due to recurrence, drug resistance, and metastasis. The expression of the mouse double minute 2 (MDM2) oncogene is upregulated in breast cancer; however, its regulatory mechanism has yet to be fully elucidated. Herein, we identified the tumor suppressor death-associated protein kinase 1 (DAPK1) as a novel MDM2 regulator by unbiased peptide library screening. DAPK1 is directly bound to MDM2 and phosphorylates it at Thr419. DAPK1-mediated MDM2 phosphorylation promoted its protein degradation via the ubiquitin–proteasome pathway, resulting in upregulated p53 expression. DAPK1 overexpression, but not its kinase activity-deficient form, decreased colony formation and increased doxorubicin-induced cell death; however, DAPK1 knockdown produced the opposite effects in human breast cancer cells. In a xenograft tumorigenesis assay, DAPK1 overexpression significantly reduced tumor formation, whereas inhibition of DAPK1 kinase activity reduced its antitumorigenic effect. Finally, DAPK1 expression was negatively correlated with MDM2 levels in human breast cancer tissues. Thus, these results suggest that DAPK1-mediated MDM2 phosphorylation and its protein degradation may contribute to its antitumorigenic function in breast cancer.
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Feng Wang,XiuZhi Tian,Lu Zhang,ChangJiu He,PengYun Ji,Yu Li,DunXian Tan,GuoShi Liu 한국동물생명공학회(구 한국동물번식학회) 2014 한국동물번식학회 한중일 심포지엄 Vol.2014 No.1
Objective: To analyze the potential beneficial effects and mechanisms of action of resveratrol on the maturation of bovine oocytes that were incubated in different concentrations of resveratrol (0.1, 1.0 or 10μM) as germinal vesicle (GV) oocytes. Design: In vitro prospective study. Setting: University research laboratory Patient(s): Animal models for human studies. Intervention(s): In vitro culture in the presence of various concentrations of the antioxidant resveratrol. Main Outcome Measures: The parameters of hormone levels, oocyte nuclear maturation, cumulus expansion, levels of intracellular glutathione and reactive oxygen species, embryonic cleavage, blastocyst formation, gene expression associated with mature bovine oocytes and cumulus cells and the level of sirtuin 1 gene expression were detected. Results: Resveratrol significantly increased progesterone secretion and decreased estradiol- 17β secretion by cumulus cells. The elevated levels of progesterone activated the Mos/MEK/p42 MAPK cascade in the oocytes. At a concentration of 1.0 μM, resveratrol significantly improved cumulus expansion, polar body formation, the (hatched)blastocyst rate and the mean number of cells/blastocyst. Meanwhile, resveratrol significantly reduced the level of ROS, increased the level of GSH. For the first time, the expression of the sirtuin 1 gene was identified in granulosa cells, cumulus cells, oocytes and blastocysts. Further studies revealed that resveratrol promoted sirtuin 1 gene expression.Conclusion(s): Resveratrol promoted bovine oocyte maturation and subsequent post- IVF embryonic development by inducing progesterone secretion and antioxidant effect, probably in a manner dependent on Sirtuin 1.
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Effects of Nano-Silica Particle Size on Fresh State Properties of Cement Paste
Hailong Sun,Xiuzhi Zhang,Peng Zhao,Di Liu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7
The rheometer was used to test the rheology of cement paste with and without nano-silica, and the fluidity and free water content were tested, the isothermal calorimetry of cement and C3S was tested and hydration products were monitored using Raman spectroscopy. A modified Bingham model was used to describe the rheological properties of the paste, and the effects of nano-silica with different particle sizes on rheological parameters including yield stress, plastic viscosity and thixotropy were derived. The results show that the fresh state properties of the cement paste vary with the particle size of nano-silica at the same dosage. The decrease in the particle size of nano-silica reduces the fluidity and free water content, but increases the yield stress and plastic viscosity. The flocculation and surface water absorption of nano-silica reduce the free water content at 5 minutes, which results in a decrease in flow diameter and an increase in yield stress. During the time evolution, the heat of hydration and Raman spectroscopy show that nano-silica with smaller particle size has higher nucleation and pozzolanic effect, that is, with the same dosage, nano-silica with small particle size provides more nucleation sites to form calcium silicate hydrate (C-S-H) seeds and to promote the hydration of C3S and the formation of C-S-H.
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